scholarly journals The Quaternization Reaction of 5-O-Sulfonates of Methyl 2,3-o-Isopropylidene-β-D-Ribofuranoside with Selected Heterocyclic and Aliphatic Amines

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2161
Author(s):  
Barbara Dmochowska ◽  
Rafał Ślusarz ◽  
Jarosław Chojnacki ◽  
Justyna Samaszko-Fiertek ◽  
Janusz Madaj
Keyword(s):  
High Resolution ◽  
13C Nmr ◽  
Aromatic Amines ◽  
Ammonium Salts ◽  
Heterocyclic Aromatic Amines ◽  
X Ray Diffraction ◽  
1H And 13C Nmr ◽  
X Ray ◽  
Micro Scale ◽  
New Compounds

The synthesis of N-((methyl 5-deoxy-2,3-O-isopropylidene-β-D-ribofuranoside)-5-yl)ammonium salts are presented. To determine the effect of the nucleophile type and outgoing group on the quaternization reaction, selected aliphatic and heterocyclic aromatic amines reacted with: methyl 2,3-O-isopropylidene-5-O-tosyl-β-D-ribofuranoside or methyl 2,3-O-isopropylidene-5-O-mesyl-β-D-ribofuranoside or methyl 2,3-O-isopropylidene-5-O-triflyl-β-D-ribofuranoside were performed on a micro scale. High-resolution 1H- and 13C-NMR spectral data for all new compounds were recorded. Additionally, the single-crystal X-ray diffraction analysis for methyl 2,3-O-isopropylidene-5-O-mesyl-β-D-ribofuranoside and selected in silico interaction models are reported.

Synthesis, Characterization, and Catalytic Activity of a Series of Aluminium–Amidate Complexes

2015 ◽  
Vol 68 (3) ◽  
pp. 357 ◽  
Author(s):  
Kevin P. Yeagle ◽  
Darryl Hester ◽  
Nicholas A. Piro ◽  
William G. Dougherty ◽  
W. Scott Kassel ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Nmr Spectroscopy ◽  
Diffraction Analysis ◽  
13C Nmr ◽  
13C Nmr Spectroscopy ◽  
X Ray Diffraction ◽  
Metathesis Reaction ◽  
Chloride Complexes ◽  
1H And 13C Nmr ◽  
X Ray

The aluminium complexes {[κ2-N,O-(t-BuNCOPh)]AlMe2}2 (2), [κ2-N,O-(t-BuNCOPh)]2AlMe (3), and [κ2-N,O-(t-BuNCOPh)]3Al (4) were prepared through the protonolysis reaction between trimethylaluminium and one, two, or three equivalents, respectively, of N-tert-butylbenzamide. Complex 2 was also prepared via a salt metathesis reaction between K(t-BuNCOPh) and dimethylaluminium chloride. Complexes 2–4 were characterized using 1H and 13C NMR spectroscopy. Single-crystal X-ray diffraction analysis of the complexes corroborated ligand : metal stoichiometries and revealed that all the amidate ligands coordinate to the aluminium ion in a κ2 fashion. The Al–amidate complexes 2–4 were viable catalyst precursors for the Meerwein–Ponndorf–Verley–Oppenauer reduction–oxidation manifold, successfully interconverting several classes of carbonyl and alcohol substrates.

Molecular structure in the solid state (X-Ray diffraction) and in solution (1H and 13C NMR) of nifurtimox and two pyrazol-1-Yl analogs

2010 ◽  
Vol 97 (11-12) ◽  
pp. 1055-1066 ◽  
Author(s):  
Ma de la Concepción Foces-Foces ◽  
Félix Hernández Cano ◽  
Rosa Ma Claramunt ◽  
Alain Fruchier ◽  
José Elguero
Keyword(s):  
Molecular Structure ◽  
Solid State ◽  
13C Nmr ◽  
X Ray Diffraction ◽  
1H And 13C Nmr ◽  
X Ray

scholarly journals 2,6-Dimethoxybenzyl Bromide

Molbank ◽  
10.3390/m1277 ◽  
2021 ◽  
Vol 2021 (3) ◽  
pp. M1277
Author(s):  
R. Alan Aitken ◽  
Elizabeth A. Saab ◽  
Alexandra M. Z. Slawin
Keyword(s):  
Melting Point ◽  
High Resolution ◽  
13C Nmr ◽  
Title Compound ◽  
Mass Spectra ◽  
1H And 13C Nmr ◽  
X Ray ◽  
Planar Molecule ◽  
First Time ◽  
Resolution Mass

The unstable title compound has been characterized for the first time. Its melting point, UV, IR, 1H and 13C-NMR and high-resolution mass spectra are presented. The X-ray structure has also been determined and shows a rather long C–Br bond perpendicular to the otherwise planar molecule.

scholarly journals Synthesis, structural and conformational study of selected N-substituted phthalimides

2005 ◽  
Vol 3 (4) ◽  
pp. 683-704 ◽  
Author(s):  
Isabel Iriepa ◽  
F. Javier Villasante ◽  
Enrique Gálvez ◽  
Antonio Herrera ◽  
Angel Sánchez ◽  
...  
Keyword(s):  
Double Resonance ◽  
13C Nmr Spectroscopy ◽  
Two Dimensional ◽  
X Ray Diffraction ◽  
1H And 13C Nmr ◽  
Conformational Studies ◽  
One Dimensional ◽  
X Ray ◽  
Nmr Techniques ◽  
New Compounds

AbstractThis paper synthesizes N-substituted phthalimides derived from nitrogen heterocycles as potential 5-HT4 ligands by using the Mitsunobu reaction. Conformational studies of some of the new compounds have been conducted using 1H and 13C-NMR spectroscopy. Proton and carbon resonances were achieved through the application of one-dimensional selective NOE, two-dimensional NMR techniques-homonuclear COSY-45, NOESY and heteronuclear 1H-13C HMQC correlated spectroscopy- and double resonance experiments. The crystal structure of compound 1 was determined by X-ray diffraction.

scholarly journals Palladium(II) complexes with R2edda derived ligands, Part I: Reaction of diisopropyl (S,S)-2,2'-(1,2-ethanediyldiimino)- dipropanoate with K2[PdCl4]

2009 ◽  
Vol 74 (4) ◽  
pp. 389-400 ◽  
Author(s):  
Bojana Krajcinovic ◽  
Goran Kaludjerovic ◽  
Dirk Steinborn ◽  
Harry Schmidt ◽  
Christoph Wagner ◽  
...  
Keyword(s):  
Dft Calculations ◽  
Diffraction Analysis ◽  
13C Nmr ◽  
Ester Group ◽  
Spectroscopic Methods ◽  
X Ray Diffraction ◽  
1H And 13C Nmr ◽  
X Ray

The reaction of K2[PdCl4] with (S,S)-(i-Pr)2eddip diester (diisopropyl (S,S)-2,2'-(1,2-ethanediyldiimino)dipropanoate) resulted in {PdCl2[(S,S)-(i- -Pr)2eddip-?2N,N']} (1) and {PdCl[(S,S)-(i-Pr)eddip-?2N,N',?O]} (2) with one hydrolyzed ester group. The compounds were characterized by spectroscopic methods and it was proved that the reaction is diastereoselective (1H- and 13C-NMR) in the case of 2 (one diastereoisomer of four possible). The structure of 2 was determined by X-ray diffraction analysis, indicating that the product is the (R,R)-N,N' configured isomer. In contrast, the reaction yielding 1 produced two of three possible diastereoisomers. DFT calculations support the formation of two diastereoisomers of 1 and of one diastereoisomer of 2.

Cs2CO3-Promoted C-3 Alkylation of 4-[(2,2-Difluoroethyl)amino]-5,5-disubstituted Furan-2(5H)-ones with Heteroarylmethyl Chlorides

Synthesis ◽  
2018 ◽  
Vol 50 (20) ◽  
pp. 4055-4062
Author(s):  
Mingan Wang ◽  
Zhao Yu ◽  
Liu Xinlei ◽  
Wang Weiwei ◽  
Geng Rui
Keyword(s):  
13C Nmr ◽  
X Ray Diffraction ◽  
1H And 13C Nmr ◽  
X Ray

4-(2,2-Difluoroethylamino)-3-(heteroarylmethyl)-5,5-disubstituted furan-2(5H)-ones were regioselectively synthesized via C-3 alkylation of 4-(2,2-difluoroethylamino)-5,5-disubstituted furan-2(5H)-ones with heteroarylmethyl chlorides using Cs2CO3 as a base in 62–85% yields. Their structures were characterized by 1H and 13C NMR, HRMS (ESI), and X-ray diffraction. This C-alkylation selectivity was rationalized by bulky hindrance and electron-withdrawing effects.

ChemInform Abstract: 1H and 13C NMR and X-Ray Diffraction Studies on Pyrazolo(1,5-b)(1,2,4)triazine. A New Heterocyclic System.

ChemInform ◽  
1989 ◽  
Vol 20 (52) ◽  
Author(s):  
D. R. SLISKOVIC ◽  
J. ASHCROFT ◽  
G. O. MORTON ◽  
J. C. JAMES ◽  
Y. LIN
Keyword(s):  
13C Nmr ◽  
Heterocyclic System ◽  
X Ray Diffraction ◽  
1H And 13C Nmr ◽  
X Ray
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