scholarly journals Effect of Supplementation with Hydroethanolic Extract of Campomanesia xanthocarpa (Berg.) Leaves and Two Isolated Substances from the Extract on Metabolic Parameters of Mice Fed a High-Fat Diet

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2693 ◽  
Author(s):  
Carla Maiara Lopes Cardozo ◽  
Aline Carla Inada ◽  
Claudia Andrea Lima Cardoso ◽  
Wander Fernando de Oliveira Filiú ◽  
Bernardo Barcelar de Farias ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Metabolic Disorders ◽  
Brazilian Cerrado ◽  
American Institute ◽  
High Fat ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Protein Expressions ◽  
Hydroethanolic Extract ◽  
Lipid Parameters

There are still controversies regarding the correlation between the beneficial effects for health and the administration of isolated compounds or crude extracts in therapeutic applications. Campomanesia xanthocarpa, found in the Brazilian Cerrado, demonstrated beneficial effects in metabolic disorders associated with obesity. We investigated the effects of Campomanesia xanthocarpa hydroethanolic extract and two isolated substances from the extract (S1 and S2) in a diet-induced obesity (DIO) model. Male Swiss mice were divided into five groups: (1) American Institute of Nutrition (AIN-93M) diet, (2) high-fat diet (HF), (3) HF supplemented with C. xanthocarpa hydroethanolic leaf extract at 100 mg/kg (HFE), (4) HF supplemented with S1 at 1 mg/kg (HFS1) and (5) HF supplemented with S2 at 1 mg/kg (HFS2). The HFS1, HFS2 and HFE groups did not present decreasing body weight or visceral adiposity gain. No differences in glycemic and lipid parameters, or in the expression of protein content in two cytokines, interleukin-6 (IL-6) and anti-inflammatory (IL-10), were observed. Only the HFS1 group displayed decreased food intake. Even though substantial effects such as an improvement in obesity features or the metabolic and histological parameters promoted by S1, S2 and the extract were not observed, further investigations are necessary to evaluate the principal genes and protein expressions involved in regulating food behavior promoted by S1.

The beneficial effects of Lactobacillus fermented black barley on high fat diet-induced fatty liver in rats

2021 ◽  
Author(s):  
Qi Guan ◽  
Xinwen Ding ◽  
Lingyue Zhong ◽  
Chuang Zhu ◽  
Pan Nie ◽  
...  
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
High Fat ◽  
Beneficial Effects ◽  
Phytochemical Composition

Long term high-fat diet (HF) can cause metabolic disorders, which might induce fatty liver. Fermented whole cereal food exhibit healthy potential due to their unique phytochemical composition and probiotics. In...

Leopoldia comosa prevents metabolic disorders in rats with high-fat diet-induced obesity

2018 ◽  
Vol 58 (3) ◽  
pp. 965-979 ◽  
Author(s):  
T. Casacchia ◽  
F. Scavello ◽  
C. Rocca ◽  
M. C. Granieri ◽  
G. Beretta ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Metabolic Disorders ◽  
High Fat ◽  
Diet Induced Obesity

scholarly journals Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Eveliina Tauriainen ◽  
Mira Luostarinen ◽  
Essi Martonen ◽  
Piet Finckenberg ◽  
Miia Kovalainen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Fatty Liver ◽  
Calorie Restriction ◽  
High Fat Diet ◽  
Adipose Tissue Inflammation ◽  
High Fat ◽  
Beneficial Effects ◽  
Diet Induced Obesity ◽  
Ad Libitum ◽  
Metabolic Performance

The potential of resveratrol to mimic beneficial effects of calorie restriction (CR) was investigated. We compared the effects of both CR (70% ofad libitumenergy intake) or resveratrol (2 g/kg or 4 g/kg food) on high-fat diet-induced obesity and fatty liver formation in C57Bl/6J mice, and we examined their effects on calorimetry, metabolic performance, and the expressions of inflammatory genes and SIRT proteins. We found that resveratrol with 4 g/kg dose partially prevented hepatic steatosis and hepatocyte ballooning and induced skeletal muscle SIRT1 and SIRT4 expression while other examined parameter were unaffected by resveratrol. In contrast, CR provided superior protection against diet-induced obesity and fatty liver formation as compared to resveratrol, and the effects were associated with increased physical activity and ameliorated adipose tissue inflammation. CR increased expressions of SIRT3 in metabolically important tissues, suggesting that the beneficial effects of CR are mediated, at least in part, via SIRT3-dependent pathways.

scholarly journals Protective effects of selenium-enriched peptides from Cardamine violifolia against high-fat diet induced obesity and its associated metabolic disorders in mice

RSC Advances ◽  
2020 ◽  
Vol 10 (52) ◽  
pp. 31411-31424
Author(s):  
Tian Yu ◽  
Jia Guo ◽  
Song Zhu ◽  
Meng Li ◽  
Zhenzhou Zhu ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Metabolic Disorders ◽  
Protective Effects ◽  
High Fat ◽  
Diet Induced Obesity

Selenium-enriched peptides from Cardamine violifolia (CSP) have excellent antioxidant functions but little is known about their effects on obesity and associated metabolic disorders in mice fed with a high-fat diet (HFD).

scholarly journals Alisol A attenuates high‐fat‐diet‐induced obesity and metabolic disorders via the AMPK/ACC/SREBP‐1c pathway

2019 ◽  
Vol 23 (8) ◽  
pp. 5108-5118 ◽  
Author(s):  
Chiakang Ho ◽  
Ya Gao ◽  
Danning Zheng ◽  
Yanjun Liu ◽  
Shengzhou Shan ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Metabolic Disorders ◽  
High Fat ◽  
Diet Induced Obesity

scholarly journals The Resin fromProtium heptaphyllumPrevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Karine Maria Martins Bezerra Carvalho ◽  
José Delano Barreto Marinho Filho ◽  
Tiago Sousa de Melo ◽  
Ana Jérsia Araújo ◽  
Josiane da Silva Quetz ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Scientific Evidence ◽  
Net Energy ◽  
High Fat ◽  
Beneficial Effects ◽  
Proinflammatory Mediators ◽  
Glucose And Lipid Metabolism ◽  
Diet Induced Obesity ◽  
Obesity In Mice

Herbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism and to have beneficial effects on metabolic disorders. The present study investigated the antiobesity properties of resin fromProtium heptaphyllum(RPH) and the possible mechanisms in mice fed a high-fat diet (HFD) for 15 weeks. Mice treated with RPH showed decreases in body weight, net energy intake, abdominal fat accumulation, plasma glucose, amylase, lipase, triglycerides, and total cholesterol relative to their respective controls, which were RPH unfed. Additionally, RPH treatment, while significantly elevating the plasma level of ghrelin hormone, decreased the levels of insulin, leptin, and resistin. Besides, HFD-induced increases in plasma levels of proinflammatory mediators TNF-α, IL-6, and MCP-1 were significantly lowered by RPH. Furthermore,in vitrostudies revealed that RPH could significantly inhibit the lipid accumulation in 3T3-L1 adipocytes (measured by Oil-Red O staining) at concentrations up to 50 μg/mL. These findings suggest that the antiobese potential of RPH is largely due to its modulatory effects on various hormonal and enzymatic secretions related to fat and carbohydrate metabolism and to the regulation of obesity-associated inflammation.

scholarly journals Deficiency of Oncostatin M Receptor β (OSMRβ) Exacerbates High-fat Diet-induced Obesity and Related Metabolic Disorders in Mice

2014 ◽  
Vol 289 (20) ◽  
pp. 13821-13837 ◽  
Author(s):  
Tadasuke Komori ◽  
Minoru Tanaka ◽  
Emiko Senba ◽  
Atsushi Miyajima ◽  
Yoshihiro Morikawa
Keyword(s):  
High Fat Diet ◽  
Metabolic Disorders ◽  
Oncostatin M ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Oncostatin M Receptor
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