scholarly journals Chemical Constituents from Roots of Sophora davidii (Franch.) Skeels and Their Glucose Transporter 4 Translocation Activities

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 756
Author(s):  
Kangdi Li ◽  
Yuanren Ma ◽  
Tongxi Zhou ◽  
Xinzhou Yang ◽  
Ho-Young Choi
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nmr Spectra ◽  
Glucose Transporter ◽  
Chemical Constituents ◽  
Ethyl Acetate Fraction ◽  
Spectroscopy Data ◽  
Glucose Transporter 4 ◽  
Sophora Davidii ◽  
New Compounds

Sophora davidii (Franch.) Skeels is a multi-purpose traditional medicine that has long been used for the treatment of various diseases. To discover the potential bioactive composition of S. davidii, a chemical investigation was thus performed. In this research, two new stilbene oligomers, Davidiol E–F (1–2), one new 4-aryl-substituted isoflavan Davidinin A (3), and one new 2-arylbenzofuran dimer, Shandougenine C (4), as well as six known compounds (5–10) were obtained from the ethyl acetate fraction of Sophora davidii (Franch.) Skeels. The structures of new compounds were established by extensive 1D and 2D nuclear magnetic resonance (NMR) spectra with mass spectroscopy data. The absolute configuration of 1–3 was assigned by comparing its experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1–10 promoted glucose transporter 4 (GLUT-4) translocations by the range of 1.28–2.60 folds, respectively. Compound 9 showed the most potent glucose transporter 4 translocations with 1.60 fold enhancement. The result attained in this study indicated that the separation and characterization of these compounds plays an important role in the research and development of new anti-diabetic drugs and pharmaceutical industry.

scholarly journals Identification of C21 Steroidal Glycosides from Gymnema sylvestre (Retz.) and Evaluation of Their Glucose Uptake Activities

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6549
Author(s):  
Meiyu Liu ◽  
Tongxi Zhou ◽  
Jinyan Zhang ◽  
Guangfeng Liao ◽  
Rumei Lu ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Glucose Uptake ◽  
Nmr Spectra ◽  
Ethyl Acetate Fraction ◽  
Gymnema Sylvestre ◽  
Spectroscopy Data ◽  
Steroidal Glycosides ◽  
L6 Cells ◽  
New Compounds

Gymnema sylvestre (Retz.) Schult is a multi-purpose traditional medicine that has long been used for the treatment of various diseases. To discover the potential bioactive composition of G. sylvestre, a chemical investigation was thus performed. In this research, four new C21 steroidal glycosides sylvepregosides A-D (1–4) were isolated along with four known compounds, gymnepregoside H (5), deacetylkidjoladinin (6), gymnepregoside G (7) and gymnepregoside I (8), from the ethyl acetate fraction of G. sylvestre. The structures of the new compounds were established by extensive 1D and 2D nuclear magnetic resonance (NMR) spectra with mass spectroscopy data. Compounds 1–6 promoted glucose uptake by the range of 1.10- to 2.37-fold, respectively. Compound 1 showed the most potent glucose uptake, with 1.37-fold enhancement. Further study showed that compounds 1 and 5 could promote GLUT-4 fusion with the plasma membrane in L6 cells. The result attained in this study indicated that the separation and characterization of these compounds play an important role in the research and development of new anti-diabetic drugs and pharmaceutical industry.

scholarly journals Davidones F and G, Two Novel Flavonoids from Sophora davidii (Franch.) Skeels

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4182
Author(s):  
Ping Song ◽  
Xuecui Li ◽  
Tongxi Zhou ◽  
Yu Peng ◽  
Ho-Young Choi ◽  
...  
Keyword(s):  
Glucose Transporter ◽  
Ethyl Acetate Fraction ◽  
2D Nmr ◽  
Side Chain ◽  
Glucose Transporter 4 ◽  
Glut 4 ◽  
Planar Structures ◽  
Nmr Data ◽  
Glut 4 Translocation ◽  
Sophora Davidii

An unprecedented novel flavanone davidone F (1) with a seven-membered ring side chain, and a novel flavanonol davidone G (2), along with 11 known flavonoids, were isolated from the ethyl acetate fraction of Sophora davidii (Franch.) Skeels. Their planar structures were established by UV, IR, HRESIMS, 1D and 2D NMR data. The relative configurations of 1 and 2 were determined by calculation of NMR chemical shift values, the absolute configuration of 1 and 2 were assigned by comparing their experimental and calculated electronic circular dichroism (ECD) spectra. Moreover, compounds 1–13 were screened for the translocation activity of glucose transporter 4 (GLUT-4), and the fluorescence intensity was increased to the range of 1.56 and 2.79 folds. Compounds 1 and 2 showed moderate GLUT-4 translocation activity with 1.64 and 1.79 folds enhancement, respectively, at a concentration of 20 μg/mL.

Chemical Constituents and Antibacterial Activity of Cissus Aralioides.

2020 ◽  
Vol 17 ◽  
Author(s):  
Balogun Olaoye Solomon ◽  
Ajayi Olukayode Solomon ◽  
Owolabi Temitayo Abidemi ◽  
Oladimeji Abdulkarbir Oladele ◽  
Liu Zhiqiang
Keyword(s):  
Plant Extract ◽  
Chemical Constituents ◽  
Ethyl Acetate Fraction ◽  
Antibacterial Activities ◽  
Sub Saharan Africa ◽  
Chromatographic Purification ◽  
Whole Plant ◽  
Sub Saharan ◽  
First Time

: Cissus aralioides is a medicinal plant used in sub-Saharan Africa for treatment of infectious diseases; however the chemical constituents of the plant have not been investigated. Thus, in this study, attempt was made at identifying predominant phytochemical constituents of the plant through chromatographic purification and silylation of the plant extract, and subsequent characterization using spectroscopic and GC-MS techniques. The minimum inhibitory concentration (MICs) for the antibacterial activities of the plant extract, chromatographic fractions and isolated compounds were also examined. Chromatographic purification of the ethyl acetate fraction from the whole plant afforded three compounds: β-sitosterol (1), stigmasterol (2) and friedelin (3). The phytosterols (1 and 2) were obtained together as a mixture. The GC-MS analysis of silylated extract indicated alcohols, fatty acids and sugars as predominant classes, with composition of 24.62, 36.90 and 26.52% respectively. Results of MICs indicated that friedelin and other chromatographic fractions had values (0.0626-1.0 mg/mL) comparable with the standard antibiotics used. Characterization of natural products from C. aralioides is being reported for the first time in this study.

New flavonoids from the roots of Sophora davidii (Franch.) Skeels and their glucose transporter 4 translocation activities

2021 ◽  
Vol 106 ◽  
pp. 104500
Author(s):  
Yuanren Ma ◽  
Tongxi Zhou ◽  
Ping Zhao ◽  
Ho-Young Choi ◽  
Ji Hao ◽  
...  
Keyword(s):  
Glucose Transporter ◽  
Glucose Transporter 4 ◽  
Sophora Davidii

scholarly journals Isolation and Characterization of Two New Antimicrobial Acids from Quercus incana (Bluejack Oak)

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Rizwana Sarwar ◽  
Umar Farooq ◽  
Sadia Naz ◽  
Nadia Riaz ◽  
Syed Majid Bukhari ◽  
...  
Keyword(s):  
Ethyl Acetate Fraction ◽  
Structural Formula ◽  
2D Nmr ◽  
Spectroscopic Technique ◽  
Pentanoic Acid ◽  
One Dimensional ◽  
Isolation And Characterization ◽  
Nmr Techniques ◽  
New Compounds

Two new compounds [1-2] were purified from ethyl acetate fraction of Quercus incana. The structure of these compounds is mainly established by using advanced spectroscopic technique such as UV, IR, one-dimensional (ID) and two-dimensional (2D) NMR techniques, and EI mass. The structural formula was deduced to be 4-hydroxydecanoic acid [1] and 4-hydroxy-3-(hydroxymethyl) pentanoic acid [2]. Both isolated compounds were tested for their antimicrobial potential and showed promising antifungal activity against Aspergillus niger and Aspergillus flavus.

Darstellung und Charakterisierung substituierter Phosphinoether und -thioether / Preparation and Characterization of Substituted Phosphinoethers and -thioethers

1995 ◽  
Vol 50 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Werner Wolfsberger ◽  
Wolfgang Burkart ◽  
Helmut Werner
Keyword(s):  
Pure State ◽  
Ring Opening ◽  
Nmr Spectra ◽  
Ir And Nmr Spectra ◽  
Elemental Analyses ◽  
Alkyl Ethers ◽  
New Compounds ◽  
Nucleophilic Ring Opening ◽  
Secondary Phosphines

The (diorganophosphinopropyl)alkyl ethers 1-7 are prepared by hydrophosphination of allylalkyl ethers with secondary phosphines. The corresponding thioethers cannot be obtained in a pure state by the same route. The nucleophilic ring opening of thiirane with lithium dialkyl phosphides, followed by the reaction with ClSi(CH3)3 or Cl(CH2)2OCH3 produces the thioethers 8-12 and 16. The silylated thioethers 8, 10 and 12 react with CH3OH/H2O to give the phosphinoethyl thiols 13-15. All new compounds have been identified and characterized by elemental analyses, IR and NMR spectra.

Characterization of Eucalyptus and Chemically Related Exudates by Nuclear Magnetic Resonance Spectroscopy

2007 ◽  
Vol 60 (11) ◽  
pp. 862 ◽  
Author(s):  
Joseph B. Lambert ◽  
Yuyang Wu ◽  
Michael A. Kozminski ◽  
Jorge A. Santiago-Blay
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Solid State ◽  
1H Nmr Spectroscopy ◽  
Nmr Spectra ◽  
Flowering Plants ◽  
Resonance Spectroscopy ◽  
The Family ◽  
First Time ◽  
Genus Eucalyptus

Exudates from six species of the genus Eucalyptus and one of the genus Corymbia (formerly Eucalyptus), from the family Myrtaceae, have been characterized by solid-state 13C and solution 1H NMR spectroscopy for the first time. Although these eucalypt kinos, as these exudates often are called, resemble resin (terpenoid) and gum (carbohydrate) exudates in physical appearance, their NMR spectra are dramatically different. In addition to lacking the characteristic terpene saturated resonances, they exhibit strong unsaturated resonances, which are weak for resins and absent for gums. We additionally report that exudates from genera of several other families of flowering plants (Amyris, Centrolobium, Guaiacum, Liquidambar, and Prosopis) also exhibit part or all of this kino spectroscopic signature.

scholarly journals Synthesis and Characterization of Some New Benzodiazepinium Salt Derivatives under microwave Irradiation

2015 ◽  
Vol 12 (4) ◽  
pp. 753-760
Author(s):  
Baghdad Science Journal
Keyword(s):  
Reaction Mechanism ◽  
Microwave Irradiation ◽  
Benzoic Acid ◽  
Nmr Spectra ◽  
Synthesis And Characterization ◽  
Benzoic Acid Derivatives ◽  
Unexpected Reaction ◽  
Ft Ir ◽  
New Compounds

An attempt to synthesize the benzoimidazol derivatives from the reaction of o-phenylenediamine and benzoic acid derivatives in the presence of ethanol and various ketones under microwave irradiation, 1 , 5 - benzodiazepinum salt derivatives were obtained instead of them. Unexpected reaction was happened for synthesis a new series of benzodiazepinium salt derivatives in a selective yield . The reaction mechanism was also discussed. The new compounds were purified and identified their structures were elucidated using various physical techniques like; FT- IR spectra, micro elemental analysis (C.H.N) and 1H NMR spectra.

scholarly journals Chemical constituents of leaves Dialium cochinchinense Pierre

2021 ◽  
Vol 4 (3) ◽  
pp. 1131-1136
Author(s):  
Vu Thi Huyen ◽  
Doan Thi Thuy Ai ◽  
Nguyen Thi Hien
Keyword(s):  
Secondary Metabolites ◽  
Nmr Spectra ◽  
Spectroscopic Analysis ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Antimicrobial Activities ◽  
Tropical Regions ◽  
First Report ◽  
Isolation And Characterization

The genus Dialium belongs to the Caesalpinioideae family, consisting of approximately 30 species distributed in the tropical regions. Secondary metabolites from the  Dialium genus have been reported to exhibit various biological activities including antioxidant, cytotoxicity and antimicrobial activities. This work describes the isolation and characterization of five compounds from the leaves of Dialium cochinchinense Pierre. Their structures were established by spectroscopic analysis, including MS and NMR spectra. Accordingly, the isolated compounds were identified to be lupeone (1), b-sitostenone (2), β-sitosterol (3), daucosterol (4), and dihydrokaempferide (5). To the best of our knowledge, this is the first report of the isolation of compounds 1 and 5 from the genus Dialium.

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