Organocatalytic Asymmetric [2 + 4] Cycloadditions of 3-Vinylindoles with ortho-Quinone Methides
Keyword(s):
Catalytic asymmetric [2 + 4] cycloadditions of 3-vinylindoles with ortho-quinone methides and their precursors were carried out in the presence of chiral phosphoric acid to afford a series of indole-containing chroman derivatives with structural diversity in overall high yields (up to 98%), good diastereoselectivities (up to 93:7 dr) and moderate to excellent enantioselectivities (up to 98% ee). This approach not only enriches the chemistry of catalytic asymmetric cycloadditions involving 3-vinylindoles but is also useful for synthesizing chiral chroman derivatives.
2020 ◽
Vol 18
(28)
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pp. 5388-5399
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2013 ◽
Vol 9
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pp. 1559-1564
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2017 ◽
Vol 83
(1)
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pp. 364-373
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2016 ◽
Vol 14
(24)
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pp. 5751-5754
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2019 ◽
Vol 84
(12)
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pp. 7883-7893
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2016 ◽
Vol 14
(7)
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pp. 2205-2209
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