Asymmetric synthesis of atropisomeric pyrazole via an enantioselective reaction of azonaphthalene with pyrazolone
Keyword(s):
The first catalytic asymmetric reaction of azonaphthalene with pyrazolone has been established. A wide range of axially chiral pyrazole derivatives have been achieved in good yields (68–99%) with excellent enantioselectivities (83–98% ee) by utilizing chiral phosphoric acid as a catalyst.
2015 ◽
Vol 13
(29)
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pp. 7993-8000
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Keyword(s):
2018 ◽
Vol 16
(8)
◽
pp. 1367-1374
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Keyword(s):
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