Regioisomers Salviprolin A and B, Unprecedented Rosmarinic Acid Conjugated Dinorditerpenoids from Salvia przewalskii Maxim

Salvia przewalskii Maxim is a perennial plant from the genus Salvia (family Lamiaceae). The roots of S. przewalskii were long used as a traditional herb to treat blood circulation related illnesses in China. As part of our continuing interest in polycyclic natural products from medicinal plants, two unprecedented adducts comprised of a dinor-diterpenoid and a 9′-nor-rosmarinic acid derivative, linked by a 1,4-benzodioxane motif (1 and 2), were isolated from the roots of S. przewalskii. Their structures were established by extensive spectroscopic approaches including 1D, 2D NMR, and HRFABMS. Their cytotoxic activities against five human tumor cell lines were evaluated.

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Synthesis and Characterization of New Palladium(II) Complexes with Ligands Derived from Furan-2-carbaldehyde and Benzaldehyde Thiosemicarbazone and their in vitro Cytotoxic Activities against Various Human Tumor Cell Lines

Zeitschrift für Naturforschung B ◽

10.1515/znb-2010-1015 ◽

2010 ◽

Vol 65 (10) ◽

pp. 1271-1278 ◽

Cited By ~ 4

Author(s):

Wilfredo Hernández ◽

Juan Paz ◽

Fernando Carrasco ◽

Abraham Vaisberg ◽

Jorge Manzur ◽

...

Keyword(s):

Tumor Cell ◽

Cell Lines ◽

Human Tumor ◽

Myelogenous Leukemia ◽

Cytotoxic Activities ◽

Spectroscopic Techniques ◽

Tumor Cell Lines ◽

Human Tumor Cell ◽

Human Tumor Cell Lines

With the ligands 4-phenyl-1-(furan-2-carbaldehyde)thiosemicarbazone, HTSC1, (1), 4-phenyl-1- (5´-phenyl-furan-2-carbaldehyde)thiosemicarbazone, HTSC2 (2), o-methoxy-benzaldehydethiosemicarbazone, HTSC3 (3), and o-cyano-benzaldehydethiosemicarbazone, HTSC4 (4), the corresponding palladium(II) complexes, Pd(TSC1)2 (5), Pd(TSC2)2 (6), Pd(TSC3)2 (7), and Pd(TSC4)2 (8) were synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structure of Pd(TSC3)2 (7) was determined by single-crystal X-ray diffraction. Complex 7 shows a squareplanar geometry, where two deprotonated ligands are coordinated to the PdII center through the nitrogen and sulfur atoms in a trans arrangement. In vitro antitumor studies against different human tumor cell lines have revealed that the palladium(II) complexes 5- 8 are more cytotoxic (IC50 values in the range of 0.21 - 3.79 μM) than their corresponding ligands (1 - 4) (> 60 μM). These results indicate that the antiproliferative activity is enhanced when thiosemicarbazone ligands are coordinated to the metal. Among the studied palladium(II) complexes, 8 exhibits high antitumor activity on K562 chronic myelogenous leukemia cells with a low value of the inhibitory concentration (IC50 = 0.21 μM).

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A Novel Sesquiterpene Polyol Ester from the Celastrus Rosthornianus with Anti-tumor Activities

Natural Product Communications ◽

10.1177/1934578x0600100704 ◽

2006 ◽

Vol 1 (7) ◽

pp. 1934578X0600100 ◽

Cited By ~ 1

Author(s):

Kuiwu Wang ◽

Yuanjiang Pan

Keyword(s):

Tumor Cell ◽

Cell Lines ◽

Human Tumor ◽

2D Nmr ◽

Spectroscopic Techniques ◽

Tumor Cell Lines ◽

Human Tumor Cell ◽

Polyol Ester ◽

Human Tumor Cell Lines ◽

Polyol Esters

A new (1) and a known (2) β-dihydroagarofuran sesquiterpene polyol esters were isolated from Celastrus rosthornianus and their structures were established by 1D- and 2D-NMR spectroscopic techniques. The two compounds exhibited anti-tumor activities against a panel of human tumor cell lines.

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New Triterpene Glycosides from Camptosorus Sibiricus

Natural Product Communications ◽

10.1177/1934578x1000501008 ◽

2010 ◽

Vol 5 (10) ◽

pp. 1934578X1000501

Author(s):

Ning Li ◽

Wan Xiao ◽

Bailing Hou ◽

Xian Li

Keyword(s):

Human Tumor ◽

2D Nmr ◽

Spectroscopic Methods ◽

Tumor Cell Lines ◽

Human Tumor Cell ◽

Human Tumor Cell Lines ◽

Mtt Method ◽

Cycloartane Glycosides ◽

New Compounds

Two new cycloartane glycosides were isolated from the whole herbs of Camptosorus sibiricus Rupr. By means of chemical and spectroscopic methods (1D and 2D NMR, HRMS, ESIMS), the structures were established as (24 R)-3β,7β,24,25,30-pentahydroxycycloartane-30- O-coumaroyl-3- O-β-D-glucopyranosyl-24- O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (1) and (24 R)-3β,7β,24,25,30-pentahydroxy-1-ene-cycloartane 24- O-β-D-glucopyranoside (2). The two new compounds were inactive in vitro against A375-S2 and Hela human tumor cell lines using the MTT method.

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New Cycloartane Glycosides from Camptosorus Sibiricus Rupr

Natural Product Communications ◽

10.1177/1934578x0800300615 ◽

2008 ◽

Vol 3 (6) ◽

pp. 1934578X0800300

Author(s):

Peng Zhang ◽

Yiyu Cheng ◽

Zhongjun Ma

Keyword(s):

Human Tumor ◽

2D Nmr ◽

Spectroscopic Methods ◽

Tumor Cell Lines ◽

Human Tumor Cell ◽

Human Tumor Cell Lines ◽

Mtt Method ◽

Cycloartane Glycosides ◽

New Compounds

Two new cycloartane glycosides were isolated from the whole herbs of Camptosorus sibiricus Rupr.. By means of chemical and spectroscopic methods (IR, 1D- and 2D- NMR, HRMS, ESI-MS), the structures were established as (24 R)-3β,7β,24,25,30-pentahydroxycycloartane 3- O-β-D-glucopyranosyl-24- O-β-D-glucopyranosyl-30- O-β-D-glucopyranoside (1), and (24 R)-3β,7β,24,25,30-pentahydroxycycloartane 3- O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-24- O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside (2). The two new compounds were tested for their cytotoxicity in vitro against human tumor cell lines (A375-S2, Hela) using the MTT method, but both compounds were inactive.

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Triterpenoids from Schisandra propinqua var. propinqua

Natural Product Communications ◽

10.1177/1934578x1601100715 ◽

2016 ◽

Vol 11 (7) ◽

pp. 1934578X1601100

Author(s):

Miao Liu ◽

Jun Wan ◽

Yuan-Qing Luo ◽

Xiao-Nian Li ◽

Xue Du ◽

...

Keyword(s):

Cell Lines ◽

Human Tumor ◽

Mass Spectrometric ◽

Cytotoxic Activities ◽

Tumor Cell Lines ◽

Human Tumor Cell ◽

Human Tumor Cell Lines ◽

X Ray ◽

Weak Activity ◽

Stems And Leaves

Four new triterpenoids, propindilactone T (1), propindilactone U (2), changnanic acid 3-methyl ester (3) and schipropinic acid (4), together with five known ones (5-9), were isolated and identified from the stems and leaves of Schisandra propinqua var. propinqua; their structures were determined based on spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was confirmed by X-ray analysis. Compounds 1, 2, and 4-9 were tested for their cytotoxic activities against five human tumor cell lines; all were inactive except for 8, which showed weak activity against some of the cell lines.

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Synthesis andIn VitroCytotoxic Activity of 2-Amino-7-(dimethylamino)-4-[(trifluoromethyl)phenyl]-4H-chromenes

E-Journal of Chemistry ◽

10.1155/2011/929673 ◽

2011 ◽

Vol 8 (2) ◽

pp. 598-602 ◽

Cited By ~ 3

Author(s):

M. Mahdavi ◽

A. Asadipour ◽

S. Rajabalian ◽

M. Vosooghi ◽

L. Firoozpour ◽

...

Keyword(s):

Tumor Cell ◽

Cell Lines ◽

Human Tumor ◽

Cytotoxic Activities ◽

Tumor Cell Lines ◽

Mass Spectral Data ◽

Human Tumor Cell ◽

Human Tumor Cell Lines ◽

Mass Spectral ◽

H Nmr

Three 2-amino-4-(trifluoromethylphenyl)-3-cyano-7-(dimethylamino) -4H-chromene derivatives were synthesized and their cytotoxic activities were determined against six human tumor cell lines using MTT assay. Condensation of 3-(dimethylamino)phenol, trifluoromethybenzaldehydes and malonitrile in ethanol containing piperidine afforded corresponding chromenes(4a-c). The structure of the synthesized compound was confirmed by1H NMR, IR and Mass spectral data. Among compounds tested, 3-trifluoromethyl analogue(3b)was the most active against all human tumor cell lines (IC50=12-45 nM).

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Anti-tumor Activities of Triterpenes from Syzygium kusukusense

Natural Product Communications ◽

10.1177/1934578x1400901106 ◽

2014 ◽

Vol 9 (11) ◽

pp. 1934578X1400901 ◽

Cited By ~ 3

Author(s):

Li-Yuan Bai ◽

Wei-Yu Lin ◽

Chang-Fang Chiu ◽

Jing-Ru Weng

Keyword(s):

Tumor Cell ◽

Human Tumor ◽

Cytotoxic Activities ◽

Tumor Cell Lines ◽

Human Tumor Cell ◽

High Potency ◽

Human Tumor Cell Lines ◽

Indigenous Plant ◽

First Time ◽

Mcf 7

In this study, we report the isolation from the stem of Syzygium kusukusense of five triterpenes, 2α-hydroxybetulinic acid (1), betulinic acid (2), platanic acid (3), ursolic acid (4), and hyptatic acid A (5). All were identified for the first time from this indigenous plant of Taiwan. Assessment of the cytotoxic activities of these compounds against a panel of human tumor cell lines, including MCF-7 breast, PC-3 prostate, and SCC2095 oral squamous cell cancers, revealed the high potency of compounds 1 (IC50, 5.7 – 7.6 μM) and, especially, 4 (IC50, 1.7 – 3.7 μM) in suppressing cell viability, which warrants further mechanistic investigations.

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Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity

Molecules ◽

10.3390/molecules24020331 ◽

2019 ◽

Vol 24 (2) ◽

pp. 331 ◽

Cited By ~ 3

Author(s):

Wei Feng ◽

Yuan Zhou ◽

Ling-Yu Zhou ◽

Li-Ying Kang ◽

Xiang Wang ◽

...

Keyword(s):

Medicinal Plant ◽

Tumor Cell ◽

Spectroscopic Analysis ◽

Human Tumor ◽

Cytotoxic Activities ◽

Tumor Cell Lines ◽

Chemical Research ◽

Human Tumor Cell ◽

Human Tumor Cell Lines ◽

Existing Data

Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A–E (1–5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1–5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC50 ranging from 5.9 to 33.9 μM compared to Cisplatin.

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