scholarly journals Low Diversity of Human Milk Oligosaccharides is Associated with Necrotising Enterocolitis in Extremely Low Birth Weight Infants

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1556 ◽  
Author(s):  
Erik Wejryd ◽  
Magalí Martí ◽  
Giovanna Marchini ◽  
Anna Werme ◽  
Baldvin Jonsson ◽  
...  
Keyword(s):  
Birth Weight ◽  
Breast Milk ◽  
Low Birth Weight ◽  
Human Milk ◽  
Amperometric Detection ◽  
Exchange Chromatography ◽  
Extremely Low Birth Weight ◽  
Human Milk Oligosaccharides ◽  
Low Birth Weight Infants ◽  
Milk Oligosaccharides

Difference in human milk oligosaccharides (HMO) composition in breast milk may be one explanation why some preterm infants develop necrotizing enterocolitis (NEC) despite being fed exclusively with breast milk. The aim of this study was to measure the concentration of 15 dominant HMOs in breast milk during the neonatal period and investigate how their levels correlated to NEC, sepsis, and growth in extremely low birth weight (ELBW; <1000 g) infants who were exclusively fed with breast milk. Milk was collected from 91 mothers to 106 infants at 14 and 28 days and at postmenstrual week 36. The HMOs were analysed with high-performance anion-exchange chromatography with pulsed amperometric detection. The HMOs diversity and the levels of Lacto-N-difucohexaose I were lower in samples from mothers to NEC cases, as compared to non-NEC cases at all sampling time points. Lacto-N-difucohexaose I is only produced by secretor and Lewis positive mothers. There were also significant but inconsistent associations between 3′-sialyllactose and 6′-sialyllactose and culture-proven sepsis and significant, but weak correlations between several HMOs and growth rate. Our results suggest that the variation in HMO composition in breast milk may be an important factor explaining why exclusively breast milk fed ELBW infants develop NEC.

scholarly journals Role of human milk in extremely low birth weight infants’ risk of necrotizing enterocolitis or death

2008 ◽  
Vol 29 (1) ◽  
pp. 57-62 ◽  
Author(s):  
J Meinzen-Derr ◽  
◽  
B Poindexter ◽  
L Wrage ◽  
A L Morrow ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Necrotizing Enterocolitis ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infants

scholarly journals Human milk oligosaccharides and their association with late-onset neonatal sepsis in Peruvian very-low-birth-weight infants

2020 ◽  
Vol 112 (1) ◽  
pp. 106-112
Author(s):  
Victor D Torres Roldan ◽  
Meritxell Urtecho S ◽  
Julia Gupta ◽  
Chloe Yonemitsu ◽  
Cesar P Cárcamo ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Neonatal Sepsis ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Human Milk Oligosaccharides ◽  
Low Birth Weight Infants ◽  
Milk Samples ◽  
Late Onset Sepsis

ABSTRACT Background Oligosaccharides are the third most abundant component in human milk. They are a potential protective agent against neonatal sepsis. Objectives We aimed to explore the association between human milk oligosaccharides (HMOs) and late-onset sepsis in very-low-birth-weight infants, and to describe the composition and characteristics of HMOs in Peruvian mothers of these infants. Methods This is a secondary data analysis of a randomized clinical trial. We conducted a retrospective cohort study of mothers and their very-low-birth-weight (&lt;1500 g) infants with ≥1 milk sample and follow-up data for &gt;30 d. HMOs were measured by high performance liquid chromatography (HPLC). We used factor analysis and the Mantel–Cox test to explore the association between HMOs and late-onset neonatal sepsis. Results We included 153 mother–infant pairs and 208 milk samples. Overall, the frequency of the secretor phenotype was 93%. Secretors and nonsecretors were defined by the presence and near-absence of α1-2-fucosylated HMOs, respectively. The most abundant oligosaccharides were 2'-fucosyllactose, lacto-N-fucopentaose (LNFP) I, and difucosyllacto-N-tetraose in secretors and lacto-N-tetraose and LNFP II in nonsecretors. Secretors had higher amounts of total oligosaccharides than nonsecretors (11.45 g/L; IQR: 0.773 g/L compared with 8.04 g/L; IQR: 0.449 g/L). Mature milk samples were more diverse in terms of HMOs than colostrum (Simpson's Reciprocal Diversity Index). We found an association of factor 3 in colostrum with a reduced risk of late-onset sepsis (HR: 0.63; 95% CI: 0.41, 0.97). Fucosyl-disialyllacto-N-hexose (FDSLNH) was the only oligosaccharide correlated to factor 3. Conclusions These findings suggest that concentrations of different HMOs vary from one individual to another according to their lactation period and secretor status. We also found that FDSLNH might protect infants with very low birth weight from late-onset neonatal sepsis. Confirming this association could prove 1 more mechanism by which human milk protects infants against infections and open the door to clinical applications of HMOs. This trial was registered at clinicaltrials.gov as NCT01525316.

Additional Protein Fortification Is Necessary in Extremely Low-Birth-Weight Infants Fed Human Milk

2016 ◽  
Vol 63 (1) ◽  
pp. 103-105 ◽  
Author(s):  
Jean-Charles Picaud ◽  
Nellie Houeto ◽  
Rachel Buffin ◽  
Claire-Marie Loys ◽  
Isabelle Godbert ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Additional Protein
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