scholarly journals Gender Differences with Dose–Response Relationship between Serum Selenium Levels and Metabolic Syndrome—A Case-Control Study

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 477 ◽  
Author(s):  
Chia-Wen Lu ◽  
Hao-Hsiang Chang ◽  
Kuen-Cheh Yang ◽  
Chien-Hsieh Chiang ◽  
Chien-An Yao ◽  
...  

Few studies have investigated the association between selenium and metabolic syndrome. This study aimed to explore the associations between the serum selenium level and metabolic syndrome as well as examining each metabolic factor. In this case-control study, the participants were 1165 adults aged ≥40 (65.8 ± 10.0) years. Serum selenium was measured by inductively coupled plasma-mass spectrometry. The associations between serum selenium and metabolic syndrome were examined by multivariate logistic regression analyses. The least square means were computed by general linear models to compare the serum selenium levels in relation to the number of metabolic factors. The mean serum selenium concentration was 96.34 ± 25.90 μg/L, and it was positively correlated with waist circumference, systolic blood pressure, triglycerides, fasting glucose, and homeostatic model assessment insulin resistance (HOMA-IR) in women, but it was only correlated with fasting glucose and HOMA-IR in men. After adjustment, the odds ratios (ORs) of having metabolic syndrome increased with the selenium quartile groups (p for trend: <0.05), especially in women. The study demonstrated that the serum selenium levels were positively associated with metabolic syndrome following a non-linear dose–response trend. Selenium concentration was positively associated with insulin resistance in men and women, but it was associated with adiposity and lipid metabolism in women. The mechanism behind this warrants further confirmation.

2021 ◽  
Vol 12 ◽  
Author(s):  
Weiwei Gui ◽  
Julong Liang ◽  
Xihua Lin ◽  
Nanjing Shi ◽  
Yiyi Zhu ◽  
...  

AimsTo explore associations between polymorphisms of IGF2-related genes including H19, IGF2, IGF2BP2 and IGF2R and Metabolic syndrome (MetS) susceptibility in the Chinese Han population.Methods66 subjects with MetS and 257 control subjects were collected for inclusion in a case-control study. PCR-RFLP was used to investigate polymorphisms in the H19, IGF2, IGF2BP2 and IGF2R genes. Elisa was used to detect the serum IGF2 concentrations.ResultsFemales carrying the GG and AG genotypes of rs680 (IGF2) exhibited a lower risk of MetS, compared with those harboring AA (adjusted OR = 0.388, p = 0.027), while GG and AG genotypes were associated with lower fasting glucose and HbA1c. In males, the Waist-to-Hip Ratio (WHR) and the level of TG were significantly higher in GG and AG genotypes than in the AA genotype of rs680 in IGF2. Levels of HDL-c were lower in men with GG and AG genotypes compared with those carrying the AA genotype. Serum IGF2 concentrations did not change among different genotypes. Finally, multifactor dimensionality reduction (MDR) analysis identified interactions between four polymorphisms: rs3741279 (H19), rs680 (IGF2), rs1470579 (IGF2BP2) and rs629849 (IGF2R).ConclusionsOur study suggests that IGF2-related genes including H19, IGF2, IGF2BP2 and IGF2R genes may play pivotal roles in the development of MetS.


2016 ◽  
Vol 6 (3) ◽  
pp. 213
Author(s):  
Alíssia Cardoso Silva ◽  
Sergio Martins Costa ◽  
Edimarlei Gonsalez Valerio ◽  
Jose Geraldo Lopes Ramos

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71799 ◽  
Author(s):  
Jui-Kun Chiang ◽  
Ying-Lung Lin ◽  
Chi-Ling Chen ◽  
Chung-Mei Ouyang ◽  
Ying-Tai Wu ◽  
...  

2019 ◽  
Vol 64 (1) ◽  
pp. 23 ◽  
Author(s):  
MukundaRanga Swaroop ◽  
BManohara Kumar ◽  
BD Sathyanarayana ◽  
D Yogesh ◽  
JC Raghavendra ◽  
...  

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