scholarly journals Association of Protein Intake during the Second Year of Life with Weight Gain-Related Outcomes in Childhood: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 583
Author(s):  
Natalia Ferré ◽  
Verónica Luque ◽  
Ricardo Closa-Monasterolo ◽  
Marta Zaragoza-Jordana ◽  
Mariona Gispert-Llauradó ◽  
...  

There is accumulating evidence that early protein intake is related with weight gain in childhood. However, the evidence is mostly limited to the first year of life, whereas the high-weight-gain-velocity period extends up to about 2 years of age. We aimed to investigate whether protein intake during the second year of life is associated with higher weight gain and obesity risk later in childhood. We conducted a systematic review with searches in both PubMed®/MEDLINE® and the Cochrane Central Register of Controlled Trials. Ten studies that assessed a total of 46,170 children were identified. We found moderate-quality evidence of an association of protein intake during the second year of life with fat mass at 2 years and at 7 years. Effects on other outcomes such as body mass index (BMI), obesity risk, or adiposity rebound onset were inconclusive due to both heterogeneity and low evidence. We conclude that higher protein intakes during the second year of life are likely to increase fatness in childhood, but there is limited evidence regarding the association with other outcomes such as body mass index or change in adiposity rebound onset. Further well-designed and adequately powered clinical trials are needed since this issue has considerable public health relevance.

2018 ◽  
Vol 33 (12) ◽  
pp. 1163-1178 ◽  
Author(s):  
Dagfinn Aune ◽  
Ingrid Snekvik ◽  
Sabrina Schlesinger ◽  
Teresa Norat ◽  
Elio Riboli ◽  
...  

2019 ◽  
Vol 300 (5) ◽  
pp. 1201-1210 ◽  
Author(s):  
Akilew A. Adane ◽  
Carrington C. J. Shepherd ◽  
Faye J. Lim ◽  
Scott W. White ◽  
Brad M. Farrant ◽  
...  

2020 ◽  
Author(s):  
Simeng Zhu ◽  
Yichen He ◽  
Chen Zhang ◽  
Yanting Wu ◽  
Hefeng Huang

Abstract Background: As a growing health problem, maternal obesity may have an adverse effect on offspring neurodevelopment. The effects of maternal overweight and obesity and excessive gestational weight gain on offspring intelligence remains unclear. This meta-analysis aimed to assess the influence of prepregnancy body mass index (BMI) and gestational weight gain on children’s intelligence.Methods: We systematically searched PubMed, Embase, Cochrane Library and Ovid Medline from their inception through July 2020. Studies assessing the association between prepregnancy BMI or gestational weight gain and children’s intelligence (from 3 years to 10 years) were screened manually before final inclusion. We included prospective and retrospective cohorts that analysed the association between prepregnancy BMI or gestational weight gain and intelligence of offspring. We used the Mantel-Haenszel fixed-effects method to compute the weight mean difference (WMD) and 95% confidence interval (CI) of each study.Results: Twelve articles were included in the systematic review, and six of them were included in the meta-analysis. There was a significant full-scale IQ reduction in children of overweight and obese women, with WMDs of -3.25 (95% CI: -3.05, -2.42) and -4.85 (95% CI: -5.93, -3.76), respectively. Compared with that in the control group, the WMDs for performance IQ were -2.40 (95% CI: -3.45, -1.34) and -5.28 (95% CI: -7.22, -3.34) in the overweight and obesity groups, respectively, and the WMDs for verbal IQ were -3.47 (95% CI: -4.38, -2.56) and -5.71 (95% CI: -7.13, -4.29), respectively. However, there was no significant reduction in children’s full-scale intelligence scores due to excessive weight gain; the WMD was -0.14 (95% CI: -0.92, 0.65).Conclusions: Prepregnancy overweight and obesity might have disadvantageous consequences on children’s intelligence; however, we observed no significant difference between excessive and normal gestational weight gain. Therefore, weight control before pregnancy is more important than that during pregnancy in terms of children’s intelligence.Trial registration: This systematic review and meta-analysis have been registered in PROSPERO (Number: CRD42020199215).


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