scholarly journals Reply to Cantarelli et al. Chronic Recurrent Multifocal Osteomyelitis Associated with Crohn Disease: A Potential Role of Exclusion Diet? Comment on “Starz et al. The Modification of the Gut Microbiota via Selected Specific Diets in Patients with Crohn’s Disease. Nutrients 2021, 13, 2125”

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4007
Author(s):  
Eliza Starz ◽  
Karolina Wzorek ◽  
Marcin Folwarski ◽  
Karolina Kaźmierczak-Siedlecka ◽  
Laura Stachowska ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Gut Microbiota ◽  
Crohn Disease ◽  
Potential Role ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Multifocal Osteomyelitis ◽  
Exclusion Diet

We congratulate Erika Cantarelli and colleagues for the presented case report in the comment entitled “Chronic Recurrent Multifocal Osteomyelitis associated to Crohn Disease (CD): a potential role of exclusion diet [...]

scholarly journals Chronic Recurrent Multifocal Osteomyelitis Associated with Crohn Disease: A Potential Role of Exclusion Diet? Comment on Starz et al. The Modification of the Gut Microbiota via Selected Specific Diets in Patients with Crohn’s Disease. Nutrients 2021, 13, 2125

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4005
Author(s):  
Erika Cantarelli ◽  
Francesco Baccelli ◽  
Gabriele Simonini ◽  
Patrizia Alvisi
Keyword(s):  
Crohn Disease ◽  
Combined Therapy ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Extraintestinal Manifestations ◽  
Microbiome Composition ◽  
Multifocal Osteomyelitis ◽  
Inflammatory Bowel ◽  
Exclusion Diet ◽  
Bone Inflammation

The efficacy of diet and its influence on gut microbiome composition has been largely demonstrated in inflammatory bowel disease (IBD). Little is known about its potential in the management of extraintestinal manifestations. We report a successful application of Crohn disease exclusion diet (CDED) in association with infliximab and methotrexate, as salvage therapy in a child affected by chronic recurrent multifocal osteomyelitis (CRMO) and Crohn disease (CD) resistant to optimized therapy. Both intestinal and bone symptoms remitted after the application of CDED. Diet may have acted on common microbic inciting agents that trigger both intestinal and bone inflammation, supporting the role of microbiota in the pathogenesis of IBD-associated extraintestinal manifestations. Our experience suggests the potential benefit of CDED in association with combined therapy in resistant patients affected by CD and extraintestinal manifestations.

Potential role of pharmacogenetics in anti-TNF treatment of rheumatoid arthritis and Crohn's disease

2007 ◽  
Vol 12 (3-4) ◽  
pp. 125-131 ◽  
Author(s):  
Wouter M. Kooloos ◽  
Dirk J. de Jong ◽  
Tom W.J. Huizinga ◽  
Henk-Jan Guchelaar
Keyword(s):  
Rheumatoid Arthritis ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Potential Role

Role of gut microbiota in Crohn’s disease

2009 ◽  
Vol 3 (5) ◽  
pp. 535-546 ◽  
Author(s):  
Phillip I Baker ◽  
Donald R Love ◽  
Lynnette R Ferguson
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Gut Microbiota

Crohn’s disease and chronic recurrent multifocal osteomyelitis in a Japanese boy

2020 ◽  
Author(s):  
Toru Fujisaki ◽  
Toshiya Matsuishi ◽  
Junji Kamizono ◽  
Masano Amamoto ◽  
Tatsuki Mizuochi
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Chronic Recurrent Multifocal Osteomyelitis ◽  
Multifocal Osteomyelitis

scholarly journals Monozygotic twins with Crohn’s disease and ulcerative colitis: a unique case report

Gut ◽  
1997 ◽  
Vol 41 (4) ◽  
pp. 557-560 ◽  
Author(s):  
N P Breslin ◽  
A Todd ◽  
C Kilgallen ◽  
C O’Morain
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Monozygotic Twins ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Environmental Agents ◽  
Inflammatory Bowel

Background—A large number of monozygotic and dizygotic twin pairs with inflammatory bowel disease have been reported. To date no twin pair has developed phenotypically discordant inflammatory bowel disease. This case report is the first documented occurrence of discordant inflammatory bowel disease occurring in monozygotic twins.Case report—Twenty two year old identical male twins presented within three months of each other with inflammatory bowel disease that proved to be discordant in overall disease type, disease distribution, clinical course, and histopathological findings. Twin 1 developed a severe pancolitis necessitating total colectomy while twin 2 developed a predominantly distal patchy colitis with frequent granulomas, controlled by aminosalicylates. Twin 1 was antineutrophil cytoplasmic antibody (ANCA) negative at the time of testing while twin 2 (Crohn’s disease) was ANCA positive. Significantly, the twins possessed the HLA type DR3-DR52-DQ2 previously associated with extensive colitis.Conclusion—This case report confirms the important role played by genetic factors in the development of inflammatory bowel disease. It also highlights the crucial role of undetermined environmental agents in dictating disease expression and phenotype.

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