Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview

Colistin is used as a last-line antibiotic for the treatment of Gram-negative multiresistant bacteria. Due to its high nephrotoxicity, Therapeutic Drug Monitoring (TDM) is recommended for dose adjustment. We aimed to evaluate the available evidence of TDM in patients given colistin to treat Gram-negative infections. In this paper, we offer an overview, using an electronic search of the literature (published up to June 2019, without language restrictions) that compares the clinical outcomes and measurements of colistin TDM. Ultimately, the Therapeutic Drug Monitoring (TDM) of colistin in Plasma could prevent nephrotoxicity risk.

Download Full-text

Mo1892 – Non-Medical Reverse Switch Between the Originator Infliximab and Its Biosimilar in Patients with Inflammatory Bowel Disease: Clinical Outcomes and Therapeutic Drug Monitoring

Gastroenterology ◽

10.1016/s0016-5085(19)39159-0 ◽

2019 ◽

Vol 156 (6) ◽

pp. S-876-S-877

Author(s):

Lorant Gonczi ◽

Akos Ilias ◽

Kata Szanto ◽

Zsuzsanna Kurti ◽

Petra Anna Golovics ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Therapeutic Drug Monitoring ◽

Clinical Outcomes ◽

Bowel Disease ◽

Drug Monitoring ◽

Therapeutic Drug ◽

Inflammatory Bowel ◽

Reverse Switch

Download Full-text

Therapeutic Drug Monitoring to Guide Infliximab Dose Adjustment is Associated with Better Endoscopic Outcomes than Clinical Decision Making Alone in Active Inflammatory Bowel Disease

Inflammatory Bowel Diseases ◽

10.1097/mib.0000000000001126 ◽

2017 ◽

Vol 23 (7) ◽

pp. 1202-1209 ◽

Cited By ~ 39

Author(s):

Orlaith B. Kelly ◽

Sarah Oʼ Donnell ◽

Joanne M. Stempak ◽

A. Hillary Steinhart ◽

Mark S. Silverberg

Keyword(s):

Decision Making ◽

Inflammatory Bowel Disease ◽

Therapeutic Drug Monitoring ◽

Bowel Disease ◽

Drug Monitoring ◽

Dose Adjustment ◽

Clinical Decision Making ◽

Clinical Decision ◽

Therapeutic Drug ◽

Inflammatory Bowel

Download Full-text

Lamotrigine drug interactions in combination therapy and the influence of therapeutic drug monitoring on clinical outcomes in paediatric patients

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/bcpt.13203 ◽

2019 ◽

Vol 125 (1) ◽

pp. 26-33 ◽

Cited By ~ 5

Author(s):

Blanka Koristkova ◽

Milan Grundmann ◽

Hana Brozmanova ◽

Ivana Kacirova

Keyword(s):

Therapeutic Drug Monitoring ◽

Combination Therapy ◽

Drug Interactions ◽

Clinical Outcomes ◽

Drug Monitoring ◽

Therapeutic Drug ◽

Paediatric Patients

Download Full-text

903: MICROBIOLOGICAL AND CLINICAL OUTCOMES OF BETA-LACTAM THERAPEUTIC DRUG MONITORING IN THE PICU

Critical Care Medicine ◽

10.1097/01.ccm.0000509579.69969.59 ◽

2016 ◽

Vol 44 (12) ◽

pp. 302-302

Author(s):

Jeffrey Cies ◽

Wayne Moore ◽

Adela Enache ◽

Arun Chopra

Keyword(s):

Therapeutic Drug Monitoring ◽

Clinical Outcomes ◽

Drug Monitoring ◽

Therapeutic Drug ◽

Beta Lactam

Download Full-text

Lamotrigine Drug Interactions in Combination Therapy and the Influence of Therapeutic Drug Monitoring on Clinical Outcomes of Adult Patients

Therapeutic Drug Monitoring ◽

10.1097/ftd.0000000000000433 ◽

2017 ◽

Vol 39 (5) ◽

pp. 543-549 ◽

Cited By ~ 7

Author(s):

Milan Grundmann ◽

Blanka Koristkova ◽

Hana Brozmanova ◽

Ivana Kacirova

Keyword(s):

Therapeutic Drug Monitoring ◽

Combination Therapy ◽

Drug Interactions ◽

Clinical Outcomes ◽

Drug Monitoring ◽

Adult Patients ◽

Therapeutic Drug

Download Full-text

Assessment of Sunitinib-Induced Toxicities and Clinical Outcomes Based on Therapeutic Drug Monitoring of Sunitinib for Patients With Renal Cell Carcinoma

Clinical Genitourinary Cancer ◽

10.1016/j.clgc.2015.01.007 ◽

2015 ◽

Vol 13 (4) ◽

pp. 350-358 ◽

Cited By ~ 37

Author(s):

Satoshi Noda ◽

Takashi Otsuji ◽

Masato Baba ◽

Tetsuya Yoshida ◽

Susumu Kageyama ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Therapeutic Drug Monitoring ◽

Cell Carcinoma ◽

Clinical Outcomes ◽

Drug Monitoring ◽

Renal Cell ◽

Therapeutic Drug

Download Full-text

Pharmacist-managed dose adjustment feedback using therapeutic drug monitoring of vancomycin was useful for patients with methicillin-resistant Staphylococcus aureus infections: a single institution experience

Infection and Drug Resistance ◽

10.2147/idr.s109485 ◽

2016 ◽

Vol Volume 9 ◽

pp. 243-252 ◽

Cited By ~ 13

Author(s):

Ryuichi Hirano ◽

Yuichi Sakamoto ◽

Junichi Kitazawa ◽

Shoji Yamamoto ◽

Naoki Tachibana

Keyword(s):

Staphylococcus Aureus ◽

Therapeutic Drug Monitoring ◽

Drug Monitoring ◽

Dose Adjustment ◽

Therapeutic Drug ◽

Single Institution ◽

Methicillin Resistant

Download Full-text

Impact of Triazole Therapeutic Drug Monitoring Availability and Timing

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.01245-19 ◽

2019 ◽

Vol 63 (10) ◽

Cited By ~ 3

Author(s):

Erin K. McCreary ◽

Meg Bayless ◽

Ahn P. Van ◽

Alexander J. Lepak ◽

Donald A. Wiebe ◽

...

Keyword(s):

Therapeutic Drug Monitoring ◽

Clinical Outcomes ◽

Antifungal Therapy ◽

Drug Concentration ◽

Drug Monitoring ◽

Therapeutic Drug ◽

Reference Laboratory ◽

Serum Concentrations ◽

Concentration Result ◽

The Impact

ABSTRACT Therapeutic drug monitoring (TDM) is an established strategy to optimize antifungal therapy with certain triazoles. While established relationships exist between concentration and safety or efficacy, the impact of TDM timing on outcomes is unknown. We report clinical outcomes, including antifungal exposure and mortality, in patients receiving institutional versus reference laboratory TDM. The availability of in-house triazole assays reduced the time to drug concentration result (12 versus 68 h; P < 0.001) and time to achieve therapeutic serum concentrations (10 versus 31 days; P < 0.001). Subtherapeutic concentrations were associated with higher patient mortality (32% versus 13.3%; P = 0.036).

Download Full-text