scholarly journals Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway

2021 ◽  
Vol 14 (2) ◽  
pp. 156
Author(s):  
Yusuf S. Althobaiti
Keyword(s):  
Drug Addiction ◽  
Place Preference ◽  
D1 Receptor ◽  
Abuse Potential ◽  
D1 Receptors ◽  
Depression And Anxiety ◽  
Conditioning Phase ◽  
Dopaminergic Pathway ◽  
First Time ◽  
D1 Receptor Antagonist

Quetiapine, an atypical antipsychotic, is effective in the management of schizophrenia, depression, and anxiety. Although quetiapine overdosage and misuse have been reported, its abuse potential has not been investigated in animals. In this study, the abuse potential of quetiapine was assessed based on the conditioned place preference (CPP) paradigm of drug addiction in a mouse model. First, mice received intraperitoneal injections of quetiapine (40, 80, or 120 mg/kg) every other day during the conditioning phase. In the second experiment, mice were pretreated with 0.03 mg/kg SKF-35866, a D1 receptor antagonist, before receiving saline or quetiapine (120 mg/kg) during the conditioning phase. No significant changes in time spent in the quetiapine-paired chamber were observed compared with time spent in the saline-paired chamber in mice treated with 40 or 80 mg/kg. In contrast, the preference to the quetiapine-paired chamber was significantly increased in mice treated with 120 mg/kg quetiapine, and this effect was blocked by SKF-35866 pretreatment. These results demonstrated, for the first time, the abuse potential of quetiapine in an animal model of drug addiction. Interestingly, this CPP-inducing effect was likely mediated by activating D1 receptors.

CNS distribution of D1 receptors: Use of a new specific D1 receptor antagonist, [3H]SCH39166

1992 ◽  
Vol 20 ◽  
pp. 123-128 ◽  
Author(s):  
James K. Wamsley ◽  
Mario E. Alburges ◽  
Robert D. McQuade ◽  
Mary Hunt
Keyword(s):  
Receptor Antagonist ◽  
D1 Receptor ◽  
D1 Receptors ◽  
D1 Receptor Antagonist

scholarly journals Effects of β-Phenylethylamine on Psychomotor, Rewarding, and Reinforcing Behaviors and Affective State: The Role of Dopamine D1 Receptors

2021 ◽  
Vol 22 (17) ◽  
pp. 9485
Author(s):  
In Soo Ryu ◽  
Oc-Hee Kim ◽  
Ji Sun Kim ◽  
Sumin Sohn ◽  
Eun Sang Choe ◽  
...  
Keyword(s):  
Affective State ◽  
Fixed Ratio ◽  
Dorsal Striatum ◽  
Place Preference ◽  
D1 Receptor ◽  
D1 Receptors ◽  
Enzyme Linked Immunosorbent Assay ◽  
Schedules Of Reinforcement ◽  
Self Administration

Beta-phenylethylamine (β-PEA) is a well-known and widespread endogenous neuroactive trace amine found throughout the central nervous system in humans. In this study, we demonstrated the effects of β-PEA on psychomotor, rewarding, and reinforcing behaviors and affective state using the open-field test, conditioned place preference (CPP), self-administration, and ultrasonic vocalizations (USVs) paradigms. We also investigated the role of the dopamine (DA) D1 receptor in the behavioral effects of β-PEA in rodents. Using enzyme-linked immunosorbent assay (ELISA) and Western immunoblotting, we also determined the DA concentration and the DA-related protein levels in the dorsal striatum of mice administered with acute β-PEA. The results showed that acute β-PEA increased stereotypic behaviors such as circling and head-twitching responses in mice. In the CPP experiment, β-PEA increased place preference in mice. In the self-administration test, β-PEA significantly enhanced self-administration during a 2 h session under fixed ratio (FR) schedules (FR1 and FR3) and produced a higher breakpoint during a 6 h session under progressive ratio schedules of reinforcement in rats. In addition, acute β-PEA increased 50-kHz USV calls in rats. Furthermore, acute β-PEA administration increased DA concentration and p-DAT and TH expression in the dorsal striatum of mice. Finally, pretreatment with SCH23390, a DA D1 receptor antagonist, attenuated β-PEA-induced circling behavior and β-PEA-taking behavior in rodents. Taken together, these findings suggest that β-PEA has rewarding and reinforcing effects and psychoactive properties, which induce psychomotor behaviors and a positive affective state by activating the DA D1 receptor in the dorsal striatum.

scholarly journals Opposing effects of dopamine on agonistic behaviour in crayfish

2021 ◽  
Author(s):  
Kengo Ibuchi ◽  
Toshiki Nagayama
Keyword(s):  
Receptor Antagonist ◽  
D2 Receptor ◽  
Inhibitory Effect ◽  
D1 Receptor ◽  
D1 Receptors ◽  
Small Animals ◽  
Agonistic Behaviour ◽  
Octopamine Receptor ◽  
Opposing Effects ◽  
D1 Receptor Antagonist

The effects of dopamine on the agonistic behaviour of crayfish were analysed. When dopamine concentrations of 1 µM were injected into large crayfish, individuals were beaten by smaller opponents, despite their physical advantage. Injection of 10 µM dopamine into small animals increased their winning rate against larger opponents. The inhibitory effect of dopamine on larger animals would be mediated by D1 receptors, and the injection of D1 receptor antagonist prohibited the onset of a loser effect in subordinate animals. The facilitating effect of dopamine on small animals would be mediated by D2 receptors, and the injection of D2 receptor antagonist prohibited the onset of a winner effect in dominant animals. Since the inhibitory effect of 1 µM dopamine was similar to 1 µM octopamine and the facilitating effect of 10 µM dopamine was similar to 1 µM serotonin, functional interactions among dopamine, octopamine, and serotonin were analyzed by co-injection of amines with their receptor antagonists in various combinations. The inhibitory effect of 1 µM dopamine disappeared when administered with D1 receptor antagonist, but remained when combined with octopamine receptor antagonist. Octopamine effects disappeared when administered with either D1 receptor antagonist or octopamine receptor antagonist, suggesting the dopamine system was downstream of octopamine. The facilitating effect of 10 µM dopamine disappeared when combined with serotonin 5HT1 receptor antagonist, as well as D2 receptor antagonist. Serotonin effects also disappeared when combined with D2 receptor antagonist, suggesting that dopamine and serotonin activated each other through mutual parallel pathways.

VTA-IC dopaminergic inputs enhances the salience to consolidate aversive but not appetitive taste recognition memory via D1 receptors

2021 ◽  
Author(s):  
Elvi Gil Lievana ◽  
Gerardo Ramirez Mejia ◽  
Oscar Urrego Morales ◽  
Jorge Luis Islas ◽  
Ranier Gutierrez ◽  
...  
Keyword(s):  
Neural Network ◽  
Recognition Memory ◽  
Dopaminergic Neurons ◽  
Insular Cortex ◽  
Taste Stimulus ◽  
D1 Receptors ◽  
Hedonic Value ◽  
The Neural Network ◽  
Aversive Taste ◽  
Dopaminergic Pathway

Taste memory involves storing information through plasticity changes in the neural network of taste, including the insular cortex (IC) and ventral tegmental area (VTA), a critical provider of dopamine. Although a VTA-IC dopaminergic pathway has been demonstrated, its role to consolidate taste recognition memory remains poorly understood. We found that photostimulation of dopaminergic neurons in the VTA or VTA-IC dopaminergic terminals of TH-Cre mice increases the salience to facilitate consolidation of a novel taste stimulus regardless of its hedonic value, without altering their taste palatability. Importantly, the inhibition of the D1-like receptor into the IC impairs the salience to facilitate consolidation of an aversive taste recognition memory. Finally, our results showed that VTA photostimulation improves the salience to facilitate consolidation of a conditioned taste aversion memory through the D1-like receptor into the IC. It is concluded that the dopamine activity from the VTA into IC is required to increase the salience to facilitate consolidation of a taste recognition memory. Notably, the D1-like receptor activity into the IC is required to consolidate both innate and learned aversive taste memories but not appetitive taste memory.

The D1 receptor antagonist, SCH 23390, induces signs of parkinsonism in African green monkeys

Life Sciences ◽  
1991 ◽  
Vol 49 (25) ◽  
pp. PL229-PL234 ◽  
Author(s):  
Matthew S. Lawrence ◽  
D.Eugene Redmond ◽  
J.D. Elsworth ◽  
J.R. Taylor ◽  
R.H. Roth
Keyword(s):  
Receptor Antagonist ◽  
Sch 23390 ◽  
D1 Receptor ◽  
D1 Receptor Antagonist ◽  
Green Monkeys

Role of dopamine D1 receptors for κ-opioid–mediated locomotor activity and antinociception during the preweanling perioda study using D1 receptor knockout mice

2000 ◽  
Vol 68 (4) ◽  
pp. 585-590 ◽  
Author(s):  
P KARPER ◽  
A NAZARIAN ◽  
C CRAWFORD ◽  
J DRAGO ◽  
S MCDOUGALL
Keyword(s):  
Locomotor Activity ◽  
Knockout Mice ◽  
D1 Receptor ◽  
D1 Receptors ◽  
Dopamine D1 Receptors
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