scholarly journals Salinomycin-Based Drug Delivery Systems: Overcoming the Hurdles in Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1120
Author(s):  
Lucia Ruxandra Tefas ◽  
Cristina Barbălată ◽  
Cristian Tefas ◽  
Ioan Tomuță

Cancer stem cells (CSCs) are reportedly responsible for the initiation and propagation of cancer. Since CSCs are highly resistant to conventional chemo- and radiotherapy, they are considered the main cause of cancer relapse and metastasis. Salinomycin (Sali), an anticoccidial polyether antibiotic, has emerged as a promising new candidate for cancer therapy, with selective cytotoxicity against CSCs in various malignancies. Nanotechnology provides an efficient means of delivering Sali to tumors in view of reducing collateral damage to healthy tissues and enhancing the therapeutic outcome. This review offers an insight into the most recent advances in cancer therapy using Sali-based nanocarriers.

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36910-36922 ◽  
Author(s):  
Min Li ◽  
Fangrong Zhang ◽  
Kerong Chen ◽  
Cheng Wang ◽  
Yujie Su ◽  
...  

Schematic illustration of the combination of NPs and MSCs drug delivery systems for cancer therapy.


2018 ◽  
Vol 288 ◽  
pp. 62-83 ◽  
Author(s):  
Hassan Dianat-Moghadam ◽  
Maryam Heidarifard ◽  
Rana Jahanban-Esfahlan ◽  
Yunes Panahi ◽  
Hamed Hamishehkar ◽  
...  

2020 ◽  
Vol 21 (11) ◽  
pp. 1084-1098
Author(s):  
Fengqian Chen ◽  
Yunzhen Shi ◽  
Jinming Zhang ◽  
Qi Liu

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.


Author(s):  
Sauraj ◽  
Anuj Kumar ◽  
Bijender Kumar ◽  
Ruchir Priyadarshi ◽  
Chhavi Sharma ◽  
...  

2019 ◽  
Vol 49 (9) ◽  
pp. 1203-1212
Author(s):  
Yan Zou ◽  
Wenya He ◽  
Bingyang Shi ◽  
Meng Zheng

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