scholarly journals Improved Release of a Drug with Poor Water Solubility by Using Electrospun Water-Soluble Polymers as Carriers

Pharmaceutics ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 34
Author(s):  
Muriel Józó ◽  
Nóra Simon ◽  
Lan Yi ◽  
János Móczó ◽  
Béla Pukánszky
Keyword(s):  
Water Solubility ◽  
Methyl Cellulose ◽  
Fiber Spinning ◽  
Water Soluble ◽  
The Other ◽  
Dissolution Behavior ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Spinning Process ◽  
Pva Fiber

In an attempt to improve the solubility of valsartan, a BCS II drug, fibers containing the drug were prepared from three water-soluble polymers, hydroxypropyl-methyl-cellulose (HPMC), polyvinyl-pyrrolidone (PVP), and polyvinyl-alcohol (PVA). Fiber spinning technology was optimized for each polymer separately. The polymers contained 20 wt% of the active component. The drug was homogenously distributed within the fibers in the amorphous form. The presence of the drug interfered with the spinning process only slightly, the diameters of the fibers were in the same range as without the drug for the HPMC and the PVA fibers, while it doubled in PVP. The incorporation of the drug into the fibers increased its solubility in all cases compared to that of the neat drug. The solubility of the drug itself depends very much on pH and this sensitivity remained the same in the HPMC and PVP fibers; the release of the drug is dominated by the dissolution behavior of valsartan itself. On the other hand, solubility and the rate of release were practically independent of pH in the PVA fibers. The different behavior is explained by the rate of the dissolution of the respective polymer, which is larger for HPMC and PVP, and smaller for PVA than the dissolution rate of the drug. The larger extent of release compared to neat valsartan can be explained by the lack of crystallinity of the drug, its better dispersion, and the larger surface area of the fibers. Considering all facts, the preparation of electrospun devices from valsartan and water-soluble polymers is beneficial, and the use of PVA is more advantageous than that of the other two polymers.

scholarly journals Formulation and Evaluation of Fast Dissolving Oral Film of Imipramine

2020 ◽  
Vol 10 (1) ◽  
pp. 182-188
Author(s):  
Rozhan A. Muhammed ◽  
Huner K. Omer
Keyword(s):  
Dosage Form ◽  
Methyl Cellulose ◽  
Petri Dish ◽  
Water Soluble ◽  
Dissolution Time ◽  
Solvent Casting ◽  
Casting Method ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Solid Dosage

Fast dissolving oral film is a new emerging solid dosage form in which it consists of thin strips administered orally and dissolved in mouth within the seconds. The study is purposed to use water soluble polymers to provide rapid film disintegration as the films are hydrated in mouth and to find the best polymer type and its concentration to formulate the drug. Initially, placebo films were prepared using solvent casting method then two formulations from the prepared placebo films were selected to formulate imipramine. The excipients were dissolved in water then the drug solution was prepared by dissolving 150 mg of drug in 5 ml of water then mixed with the excipients and they were mixed gently and casted in disposable Petri dishes and left for 24 h in oven to provide film dryness. Then, the films removed from Petri dish and cut to 2 cm × 2 cm small strips. Then, the tests were performed. Successful films were prepared by 45% hydroxypropyl methyl cellulose (HPMC) and 50% sodium carboxymethyl cellulose (NaCMC). The films were smooth, easily removed from Petri dish without tearing and homogenous. The thin films were mechanically stable that they could be handled without breaking due to their good folding endurance which was more than 400. The pH of the films was accepted since they were around saliva pH (5.3–6.9). The films disintegration time was <60 min since water-soluble polymers were used and this property provided rapid drug release from the formulation in which it was 15–20 min for both of the drug-containing films, while dissolution time for the imipramine conventional tablet was about 60 min. Imipramine can be formulated as a new dosage form (fast dissolving film) using 45% HPMC and 50% NaCMC as polymer using solvent casting method to ease the drug administration for psychotic and pediatric patients since no water is required for this solid dosage for administration.

scholarly journals IMPROVING THE EFFICIENCY OF MORTARS OF DOMESTIC PRODUCTION

2019 ◽  
pp. 22-29
Author(s):  
Н. Оноприенко ◽  
N. Onoprienko Natal'ya Nikolaevna ◽  
О. Сальникова ◽  
O. Sal'nikova
Keyword(s):  
Methyl Cellulose ◽  
Breaking Load ◽  
Water Soluble ◽  
Wall Material ◽  
Domestic Water ◽  
Domestic Production ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
High Adhesion ◽  
Positive Effect

The additives of polymers of domestic and foreign production used in compositions of dry construction mixes are given. The need of expansion the range of polymer additives produced in Russia for competitive production is proved. It is shown that use of masonry mortars with additives of domestic water-soluble polymers (methyl cellulose, oxyethylcellulose) in amount of 0.5–1 % prevents softening and cracking of masonry at the junction of bricks, provides high adhesion to stone wall material, increases solidity of masonry. Masonry earing capacity on cement and sand solution with additive of 0.5 % of methyl cellulose increases by 20 % above in comparison with a bricklaying on traditional solution, without polymer additive. The appearance of main cracks in the central compression of the masonry on cement-polymer solution occurs at higher intensities of the breaking load. Studied domestic additives of water-soluble polymers are environmentally friendly products of domestic production. The low percentage of polymer has a positive effect on the water resistance and cost of masonry. The developed masonry mortars can be recommended for buildings and constructions subjected to dynamic effects.

scholarly journals Modeling, simulation, and optimization of advanced oxidation technologies for treatment of polymeric wastewater

2021 ◽  
Author(s):  
Samira Ghafoori
Keyword(s):  
Water Solubility ◽  
Advanced Oxidation ◽  
Industrial Effluents ◽  
Chemical Compounds ◽  
Water Soluble ◽  
Aqueous Environment ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
The Past ◽  
Advanced Oxidation Technologies

Most synthetic water-soluble polymers from industrial effluents are discarded into the aqueous environment. Due to their water solubility they can reach conventional sewage disposal systems and contaminate water resources as they are not amenable to biodegradation. Therefore, the possibility of rendering these materials to biologically manageable chemical compounds is a challenging task. The applications of advanced oxidation technologies (AOTs) for treating wastewater containing recalcitrant and inhibitory organics have risen drastically during the past few decades. AOTs mediate fast degradation or decomposition of the target organic compounds by producing free radical species. In this study, the photooxidative degradation of water-soluble polymers in wastewater is studied using different methods of AOTs. The experimental design, statistical analysis, and optimization of different processes of AOTs are investigated employing various methods of response surface methodology (RSM). Using RSM, the effects of different process parameters on the response function are determined. Also, a detailed mechanistic kinetic model is developed along with photoreactor design and modeling for a laboratory-scale batch recirculating photoreactor. Most synthetic water-soluble polymers from industrial effluents are discarded into the aqueous environment. Due to their water solubility they can reach conventional sewage disposal systems and contaminate water resources as they are not amenable to biodegradation. Therefore, the possibility of rendering these materials to biologically managable chemical compounds is a challenging task. The applications of advanced oxidation technologies (AOTs) for treating wastewater containing recalcitrant and inhibitory organics have risen drastically during the past few decades. AOTs mediate fast degradation or decomposition of the target organic compounds by producing free radical species. In this study, the photooxidative degradation of water-soluble polymers in wastewater is studied using different methods of AOTs. The experimental design, statistical analysis, and optimization of different processes of AOTs are investigated employing various methods of response surface methodology (RSM). Using RSM, the effects of different process parameters on the response function are determined. Also, a detailed mechanistic kinetic model is developed along with photoreactor design and modeling for a laboratory-scale batch recirculating photoreactor

scholarly journals Modeling, simulation, and optimization of advanced oxidation technologies for treatment of polymeric wastewater

2021 ◽  
Author(s):  
Samira Ghafoori
Keyword(s):  
Water Solubility ◽  
Advanced Oxidation ◽  
Industrial Effluents ◽  
Chemical Compounds ◽  
Water Soluble ◽  
Aqueous Environment ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
The Past ◽  
Advanced Oxidation Technologies

Most synthetic water-soluble polymers from industrial effluents are discarded into the aqueous environment. Due to their water solubility they can reach conventional sewage disposal systems and contaminate water resources as they are not amenable to biodegradation. Therefore, the possibility of rendering these materials to biologically manageable chemical compounds is a challenging task. The applications of advanced oxidation technologies (AOTs) for treating wastewater containing recalcitrant and inhibitory organics have risen drastically during the past few decades. AOTs mediate fast degradation or decomposition of the target organic compounds by producing free radical species. In this study, the photooxidative degradation of water-soluble polymers in wastewater is studied using different methods of AOTs. The experimental design, statistical analysis, and optimization of different processes of AOTs are investigated employing various methods of response surface methodology (RSM). Using RSM, the effects of different process parameters on the response function are determined. Also, a detailed mechanistic kinetic model is developed along with photoreactor design and modeling for a laboratory-scale batch recirculating photoreactor. Most synthetic water-soluble polymers from industrial effluents are discarded into the aqueous environment. Due to their water solubility they can reach conventional sewage disposal systems and contaminate water resources as they are not amenable to biodegradation. Therefore, the possibility of rendering these materials to biologically managable chemical compounds is a challenging task. The applications of advanced oxidation technologies (AOTs) for treating wastewater containing recalcitrant and inhibitory organics have risen drastically during the past few decades. AOTs mediate fast degradation or decomposition of the target organic compounds by producing free radical species. In this study, the photooxidative degradation of water-soluble polymers in wastewater is studied using different methods of AOTs. The experimental design, statistical analysis, and optimization of different processes of AOTs are investigated employing various methods of response surface methodology (RSM). Using RSM, the effects of different process parameters on the response function are determined. Also, a detailed mechanistic kinetic model is developed along with photoreactor design and modeling for a laboratory-scale batch recirculating photoreactor

New quenching media based on water-soluble polymers

1981 ◽  
Vol 23 (2) ◽  
pp. 104-106 ◽  
Author(s):  
A. V. Tolstousov ◽  
O. A. Bannykh
Keyword(s):  
Water Soluble ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Quenching Media

scholarly journals SANS quantification of bound water in water-soluble polymers across multiple concentration regimes

Soft Matter ◽  
2021 ◽  
Author(s):  
Helen Yao ◽  
Bradley D. Olsen
Keyword(s):  
Neutron Scattering ◽  
Small Angle ◽  
Small Angle Neutron Scattering ◽  
Bound Water ◽  
Water Soluble ◽  
Wide Concentration Range ◽  
Water Molecules ◽  
Water Soluble Polymers ◽  
Soluble Polymers

Small-angle neutron scattering is used to measure the number of bound water molecules associating with three polymers over a wide concentration range. Different fitting workflows are evaluated and recommended depending on the concentration regime.

scholarly journals Flow Enhancement of Water-Soluble Polymers through Porous Media by Preshearing

2021 ◽  
Author(s):  
Mohsen Mirzaie Yegane ◽  
Julia Schmidt ◽  
Fatima Dugonjic-Bilic ◽  
Benjamin Gerlach ◽  
Pouyan E. Boukany ◽  
...  
Keyword(s):  
Porous Media ◽  
Water Soluble ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Flow Enhancement
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