scholarly journals Complementary Color Tuning by HCl via Phosphorescence-to-Fluorescence Conversion on Insulated Metallopolymer Film and Its Light-Induced Acceleration

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 244 ◽  
Author(s):  
Shunichi Kaneko ◽  
Hiroshi Masai ◽  
Takuya Yokoyama ◽  
Maning Liu ◽  
Yasuhiro Tachibana ◽  
...  
Keyword(s):  
Uv Irradiation ◽  
Color Change ◽  
Molecular Engineering ◽  
Next Generation ◽  
Color Tuning ◽  
Tunable Materials ◽  
Color Tunable ◽  
Complementary Color ◽  
Solid Film ◽  
New Guidelines

An insulated metallopolymer that undergoes phosphorescence-to-fluorescence conversion between complementary colors by an acid-stimulus is proposed as a color-tunable material. A Pt-based phosphorescent metallopolymer, where the conjugated polymeric backbone is insulated by a cyclodextrin, is depolymerized by HCl via acidic cleavage of Pt-acetylide bonds to form a fluorescent monomer. The insulation enables phosphorescence-to-fluorescence conversion to take place in the solid film. Rapid color change was achieved by accelerating the reaction between the metallopolymer and HCl by UV irradiation. These approaches are expected to provide new guidelines for the development of next-generation color-tunable materials and printable sensors based on precise molecular engineering.

Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability

2018 ◽  
Vol 46 (6) ◽  
pp. 1559-1565 ◽  
Author(s):  
Obinna C. Ubah ◽  
Magdalena J. Buschhaus ◽  
Laura Ferguson ◽  
Marina Kovaleva ◽  
John Steven ◽  
...  
Keyword(s):  
Adaptive Immune System ◽  
Chain Structure ◽  
Molecular Engineering ◽  
Next Generation ◽  
Therapeutic Success ◽  
Domain Structures ◽  
Therapeutic Molecules ◽  
The Face ◽  
Delivery Options ◽  
Models Of Disease

Therapeutic mAbs have delivered several blockbuster drugs in oncology and autoimmune inflammatory disease. Revenue for mAbs continues to rise, even in the face of competition from a growing portfolio of biosimilars. Despite this success, there are still limitations associated with the use of mAbs as therapeutic molecules. With a molecular mass of 150 kDa, a two-chain structure and complex glycosylation these challenges include a high cost of goods, limited delivery options, and poor solid tumour penetration. There remains an urgency to create alternatives to antibody scaffolds in a bid to circumvent these limitations, while maintaining or improving the therapeutic success of conventional mAb formats. Smaller, less complex binders, with increased domain valency, multi-specific/paratopic targeting, tuneable serum half-life and low inherent immunogenicity are a few of the characteristics being explored by the next generation of biologic molecules. One novel ‘antibody-like’ binder that has naturally evolved over 450 million years is the variable new antigen receptor (VNAR) identified as a key component of the adaptive immune system of sharks. At only 11 kDa, these single-domain structures are the smallest IgG-like proteins in the animal kingdom and provide an excellent platform for molecular engineering and biologics drug discovery. VNAR attributes include high affinity for target, ease of expression, stability, solubility, multi-specificity, and increased potential for solid tissue penetration. This review article documents the recent drug developmental milestones achieved for therapeutic VNARs and highlights the first reported evidence of the efficacy of these domains in clinically relevant models of disease.

SYNTHESIS OF ASYMMETRIC DIYNES, DIFFERING IN NUMBER OF METHYLENE FRAGMENTS AND THEIR ABILITY TO SOLID STATE POLYMERIZATION

1970 ◽  
Author(s):  
Boris S. Tanaseichuk ◽  
Margarita K. Pryanichnikova ◽  
Alexey A. Burtasov
Keyword(s):  
Solid State ◽  
Uv Irradiation ◽  
Triple Bond ◽  
Color Change ◽  
Sodium Ethoxide ◽  
Polymerization Process ◽  
Solid State Polymerization ◽  
Bright Color ◽  
Two Stages ◽  
Conjugated Diynes

Asymmetric conjugate diynes are of considerable interest because of their ability to solid state polymerization to form polymers with an ordered tough polyene structure. The capacity of conjugated diynes to such polymerization is determined by the presence and nature of the substituents in the side chain diynes and the degree of their distance from the diacetylenic fragment. To evaluate the effect of the distance a bulky substituent of conjugate diyne′s fragment for ability of asymmetric diacetylenes ordered solid state polymerization were prepared 4 alkildiinil′s ether of p-hydroxybenzaldehyde with varying degrees of distance diyne′s fragment from the benzene ring.Synthesis of alkildiinil′s esters of p-hydroxybenzaldehyde was carried out in two stages. At the first stage by alkylation of p-hydroxybenzaldehyde of corresponding of toluenesulfonate′s terminal alkynol or ω-bromalkines in the presence of sodium ethoxide was prepared monoalkinil′s ether of p-hydroxybenzaldehyde, in which the terminal triple bond is separated from the phenoxyl′s fragment 1, 2, 3 and 4 methylene′s groups. Use as a alkylating agent of toluenesulfonate′s terminal alkynols, which differ in low volatility compared ω-bromalkines, gives a fairly high (~ 60%) the yield of desired products. At the second stage according to the method of Kadio-Chodkiewich the condensation-3-brompropin-2-ol with the corresponding monoalkinil′s esters of p-hydroxybenzaldehyde were alkildiynil′s ethers of p-hydroxybenzaldehyde, which have a terminal triple bond is separated from the benzene′s ring 1, 2, 3 and 4 methylene′s groups. The effect of the degree of remoteness of the conjugate diyne′s fragment from the bulk p-formilfenoksil′s substituents on these compounds ability to solid state polymerization under UV irradiation was studied by the asymmetric diynes. About the polymerization rate was judged visually by a color change. All investigated diynes exhibited the ability to solid state polymerization. The rate of it was largely dependent of the number of methylene′s fragments, separating p-formilfenoksil′s ring from diyne′s fragment. If the irradiation of diynes containing 3 or 4 methylene′s fragments, color change of almost colorless to dark brown occurred within 5-6 h, then diynes containing 1 or 2 of the methylene′s fragments was required for 24 h. It goes to show that the increase the length of the methylene′s chain, postpones surround p-formilfenoksil′s fragment from a paired diyne′s fragment, eases  the solid state polymerization. However, the absence of the bright color of the polymer characteristic polydiacetylene′s ordered structures indicates that, polymerization was not well-ordered in out case.Thus, the results showed that administration of methylene′s fragments, causing varying degrees of remoteness of the conjugate diyne′s fragment from the bulk p-formilfenoksil′s fragment, has a significant impact on the ability of asymmetric conjugate diynes to solid state polymerization under UV irradiation. The increase in the degree of remoteness promotes their solid state polymerization, those namely the structure of asymmetric diynes determines their behavior in the polymerization process.

scholarly journals Color-tunable white-light of binary tris-β-diketonate-(Dy3+, Gd3+ ) complexes’ blend under single wavelength excitation

2020 ◽  
Author(s):  
Qi Shi
Keyword(s):  
Solid State ◽  
Blue Light ◽  
White Light ◽  
Mixed Complex ◽  
Yellow Light ◽  
Color Tuning ◽  
Color Tunable ◽  
Fluorescence Titrations

Based on the Dy³⁺-centered yellow-light and the ligands-based blue-light of the iso-structural two complexes [Ln(acac)3(5-Br-2,2′-bpy)] (Ln³⁺ = Dy³⁺ (2) or Gd³⁺ (3); Hacac = acetylacetone, 5-Br-2,2′-bpy = 5-bromo-2,2′-bipyridine), respectively, the stoichiometric fluorescence titrations of their tris-β-diketonate-(Dy³⁺, Gd³⁺x)-mixed complex, show that it is capable of the smooth color-tuning (yellow- to white- and to blue-light) under single wavelength excitation. Moreover, through the dichromatic integration, the binary tris-β-diketonate-(Dy³⁺, Gd³⁺x) complex exhibits the straightforward white-light in solid-state.

Highly efficient and color tunable thermally activated delayed fluorescent emitters using a “twin emitter” molecular design

2016 ◽  
Vol 52 (2) ◽  
pp. 339-342 ◽  
Author(s):  
Mounggon Kim ◽  
Sang Kyu Jeon ◽  
Seok-Ho Hwang ◽  
Sang-shin Lee ◽  
Eunsun Yu ◽  
...  
Keyword(s):  
High Efficiency ◽  
Molecular Design ◽  
Color Tuning ◽  
Thermally Activated ◽  
Highly Efficient ◽  
Color Tunable

High efficiency and color tuning of thermally activated delayed fluorescent emitters were achieved at the same time by designing emitters with a twin emitter molecular design.

Solid Film Device to Visualize UV-Irradiation

2003 ◽  
Vol 32 (10) ◽  
pp. 888-889 ◽  
Author(s):  
Yuuki Kaburagi ◽  
Sumio Tokita ◽  
Masao Kaneko
Keyword(s):  
Uv Irradiation ◽  
Solid Film

Delaminated layered rare-earth hydroxide composites with ortho-coumaric acid: color-tunable luminescence and blue emission due to energy transfer

2015 ◽  
Vol 3 (27) ◽  
pp. 7143-7152 ◽  
Author(s):  
Feifei Su ◽  
Qingyang Gu ◽  
Shulan Ma ◽  
Genban Sun ◽  
Xiaojing Yang ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Rare Earth ◽  
Blue Emission ◽  
Blue Luminescence ◽  
Coumaric Acid ◽  
Color Tuning ◽  
Color Tunable ◽  
Acid Color

LRH (R = Tb, Y) composites with ortho-coumaric acid and OS show color-tuning luminescence especially blue luminescence via energy transfer.

scholarly journals Green Synthesis of Gold Nanoparticles from Coprinus comatus, Agaricaceae, and the Effect of Ultraviolet Irradiation on Their Characteristics

2021 ◽  
Vol 18 (8) ◽  
Author(s):  
Ghassan Adnan NAEEM ◽  
Ahmed Saadoun JALOOT ◽  
Mustafa Nadhim OWAID ◽  
Rasim Farraj MUSLIM
Keyword(s):  
Gold Nanoparticles ◽  
Uv Irradiation ◽  
Color Change ◽  
Visible Spectrum ◽  
Face Centered Cubic ◽  
Coprinus Comatus ◽  
Light Yellow ◽  
Uv Visible ◽  
Face Centered ◽  
Nanoscale Range

The present research aims to produce gold nanoparticles (AuNPs) from the aqueous extract of locally isolated mushroom Coprinus comatus from Hit city, Iraq. Its properties were studied using the optical vision, UV-Vis, EDX, XRD, FTIR, AFM, and Zetasizer analyses. The exposure of the colloidal solution of AuNPs to UV radiation was investigated for 1, 2, and 3 h. The results showed the color change of the interaction mixture from light yellow to purple after 25 min. The lambda max of the absorbance reached 530 nm using UV-Visible spectrum as evident in the formation of AuNPs. FTIR spectra revealed the presence of functional groups related to peptides, proteins, flavonoids, monosaccharides, and phenolic compounds, which reduced gold ions. The EDX technique showed that the formed nanoparticles were AuNPs. XRD results showed that AuNPs have a face-centered cubic (fcc) crystal. The UV irradiation at different times led to an increase in the intensity of absorbance and sizes of AuNPs from 17.39 nm before the irradiation and switched to 58.16, 59.13, and 47.35 nm after 1, 2, and 3 h, respectively, but their sizes remained within the nanoscale range (less than 100 nm). In conclusion, the best result was observed after about an hour on the effects of UV irradiation on sizes of AuNPs, which reached smaller nanoparticles compared with times 2 and 3 h.

scholarly journals Color tuning of Bi3+-doped double-perovskite Ba2(Gd1−x,Lux)NbO6 (0 ≤ x ≤ 0.6) solid solution compounds via crystal field modulation for white LEDs

RSC Advances ◽  
2020 ◽  
Vol 10 (43) ◽  
pp. 25500-25508
Author(s):  
Xufang Tang ◽  
Dingfeng Jin ◽  
Jun Zhao ◽  
Min Jin
Keyword(s):  
Solid Solution ◽  
Rare Earth ◽  
Crystal Field ◽  
Solid Solutions ◽  
Double Perovskite ◽  
Color Tuning ◽  
White Leds ◽  
Color Tunable ◽  
Field Modulation

Nowadays, rare-earth-free color-tunable solid solutions are receiving great attention.

scholarly journals Conformal monolayer contacts with lossless interfaces for perovskite single junction and monolithic tandem solar cells

2019 ◽  
Vol 12 (11) ◽  
pp. 3356-3369 ◽  
Author(s):  
Amran Al-Ashouri ◽  
Artiom Magomedov ◽  
Marcel Roß ◽  
Marko Jošt ◽  
Martynas Talaikis ◽  
...  
Keyword(s):  
Solar Cells ◽  
Molecular Engineering ◽  
Next Generation ◽  
Tandem Solar Cells ◽  
Single Junction

We introduce new hole-selective contacts for next-generation perovskite photovoltaics and point to design paths for molecular engineering of perfect interfaces.

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