scholarly journals Prognostic Role of DNA Methylation Analysis from Oral Brushing in Oral Squamous Cell Carcinoma

Proceedings ◽  
2019 ◽  
Vol 35 (1) ◽  
pp. 37
Author(s):  
Russo ◽  
Lenzi ◽  
Rossi ◽  
Morandi ◽  
Tarsitano ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Methylation Profile ◽  
Prognostic Role ◽  
Methylation Analysis ◽  
Dna Methylation Analysis

The aim of this study was to investigate the prognostic role of methylation profile of 13 genes starting from oral brushing collected in a group of patients affected by oral squamous cell carcinoma (OSCC). [...]

Comprehensive study on the prognostic role of osteopontin expression in oral squamous cell carcinoma

Oral Oncology ◽  
2009 ◽  
Vol 45 (9) ◽  
pp. 798-802 ◽  
Author(s):  
Chih-Yen Chien ◽  
Chih-Ying Su ◽  
Hui-Ching Chuang ◽  
Fu-Min Fang ◽  
Hsuan-Ying Huang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Role ◽  
Osteopontin Expression ◽  
Comprehensive Study

scholarly journals Prognostic Potential of Tumor-Infiltrating Immune Cells in Resectable Oral Squamous Cell Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2268
Author(s):  
Ana Caruntu ◽  
Liliana Moraru ◽  
Mihai Lupu ◽  
Florina Vasilescu ◽  
Marius Dumitrescu ◽  
...  
Keyword(s):  
Patient Outcome ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immune Cells ◽  
Prognostic Role ◽  
Immune Microenvironment ◽  
Improved Outcome

(1) Background: The immune microenvironment plays an important role in carcinogenesis and has prognostic potential in many types of cancer. In this study we assess the prognostic character of tumor-infiltrating immune cells CD4+, CD8+ and CD56+ in resectable oral squamous cell carcinoma (OSCC); (2) Methods: We have evaluated the densities of CD4+, CD8+ and CD56+ in two distinct compartments, intratumor and invasion front, in 90 patients with OSCC; (3) Results: Significant differences were found between the tumor compartments for the CD4+ and CD8+ lymphocytes. An improved outcome (OS) was seen in patients with high densities of intratumor CD8+ lymphocytes (p = 0.0086), CD8+ lymphocytes at the front of invasion (p = 0.0011) and for intratumor CD56+ cells (p = 0.0016). Multivariate analysis confirmed the independent prognostic role of CD8+ at the front of invasion (OR = 3.75, CI95% 1.17–12.35, p = 0.026) and for intratumor CD56+ cells (OR = 3.669, CI95% 1.09–15.37, p = 0.035); (4) Conclusions: Tumor-infiltrating CD8+ lymphocytes at the front of invasion and CD56+ in the intratumor compartment display predictive traits in OSCC. A reach immune infiltration with these types of cells is associated with an improved patient outcome.

scholarly journals Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study

Medicina ◽  
2020 ◽  
Vol 56 (2) ◽  
pp. 57 ◽  
Author(s):  
Yi-Ju Lee ◽  
Lung Chan ◽  
Chung-Min Yeh ◽  
Chien-Hsun Lee ◽  
Wen-Wei Sung
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Prognostic Role ◽  
Favorable Prognosis ◽  
Betel Quid Chewing ◽  
History Of

Background and Objectives: Patients with oral squamous cell carcinoma (OSCC), a common malignancy in Asian countries, have a poor prognosis. We investigated the role of Krüppel-like factor 17 (KLF17) and its prognostic significance in OSCC. Materials and Methods: KLF17 expression was measured by immunohistochemical staining of specimens from 283 patients with OSCC. We analyzed correlations between KLF17 expression and clinicopathologic features and between KLF17 expression and overall survival. The prognostic value of KLF17 was tested using Kaplan–Meier analysis and Cox proportional hazard models. Results: Among the 283 patients, high KLF17 expression was significantly associated with an early OSCC stage and low T-value (p = 0.033 and p = 0.036, respectively). The five-year survival rates were better in patients with high KLF17 expression than with low expression (66.5% and 49.6%, respectively). The prognostic role of KLF17 was further confirmed through multivariate analysis (hazard ratio 1.506, 95% confidence interval 1.034–2.191, p = 0.033). The prognostic value was more significant in patients with a history of betel quid chewing or with a low T-value. Conclusions: High KLF17 expression can serve as a marker for a favorable prognosis in patients with OSCC. The prognostic role of KLF17 is more significant in patients with a history of betel quid chewing or a low T-value.

Prognostic role of p27Kip1 expression in oral squamous cell carcinoma in Taiwan

Oral Oncology ◽  
2002 ◽  
Vol 38 (2) ◽  
pp. 172-178 ◽  
Author(s):  
Mark Yen-Ping Kuo ◽  
Hong-Yuan Hsu ◽  
Sang-Heng Kok ◽  
Ru-Cheng Kuo ◽  
Hsian Yang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Role ◽  
P27kip1 Expression

Prognostic role of p21WAF1 expression in areca quid chewing and smoking-associated oral squamous cell carcinoma in Taiwan

2002 ◽  
Vol 31 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Mark Yen-Ping Kuo ◽  
Jehn-Shyun Huang ◽  
Sang-Heng Kok ◽  
Ying-Shiung Kuo ◽  
Chun-Pin Chiang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Role

scholarly journals Gender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e50104 ◽  
Author(s):  
Chih-Jung Chen ◽  
Wen-Wei Sung ◽  
Yueh-Min Lin ◽  
Mu-Kuan Chen ◽  
Ching-Hsiao Lee ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Gender Difference ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Interleukin 6 ◽  
Prognostic Role

scholarly journals Overexpression of EIF5A2 Predicts Poor Prognosis in Patients with Oral Squamous Cell Carcinoma

Diagnostics ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 436
Author(s):  
Yueh-Min Lin ◽  
Mei-Ling Chen ◽  
Chia-Lo Chen ◽  
Chung-Min Yeh ◽  
Wen-Wei Sung
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Translation Initiation Factor ◽  
Beta Catenin ◽  
Prognostic Role ◽  
N Value ◽  
Emt Markers

Oral squamous cell carcinoma (OSCC) is the most common epithelial malignancy affecting the oral cavity, and it is especially significant in Asian countries. Patients diagnosed with OSCC have an unfavorable prognosis and additional prognostic markers would help improve therapeutic strategies. We sought to investigate the association between eukaryotic translation initiation factor 5A2 (EIF5A2) and epithelial–mesenchymal transition (EMT) markers as well as the prognostic significance of EIF5A2 in OSCC. The expression of EIF5A2 and EMT markers was measured through the immunohistochemical staining of specimens from 272 patients with OSCC. In addition, the correlation between different clinicopathological factors and EIF5A2 expression was analyzed. The prognostic role of EIF5A2 was then analyzed via Kaplan–Meier analysis and Cox proportional hazard models. Among the 272 patients, high EIF5A2 expression was significantly associated with an advanced N value (p = 0.008). High tumor expression of EIF5A2 was prone to the expression of low E-cadherin and high beta-catenin (p = 0.046 and p = 0.020, respectively). Patients with high EIF5A2 expression had unfavorable five-year survival rates as compared with those with low expression (49.7% and 67.3%, respectively). The prognostic role of EIF5A2 was further confirmed through multivariate analysis (hazard ratio = 1.714, 95% confidence interval: 1.134–2.590, p = 0.011). High EIF5A2 expression is associated with an advanced N value and EMT markers and may serve as a marker for an unfavorable prognosis in patients with OSCC.

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