scholarly journals Empagliflozin Use and Fournier’s Gangrene: Case Report and Systematic Literature Review

Surgeries ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 174-179
Author(s):  
Mario Antunes ◽  
Antonio Cabrera de León ◽  
Damiano Pizzol ◽  
Amir Hussein Abubacar Seni ◽  
Mike Trott ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Female Patient ◽  
Low Income ◽  
Fournier’S Gangrene ◽  
Genital Infection ◽  
Fournier's Gangrene ◽  
Balanced Diet ◽  
Low Income Setting

Background: Fournier’s gangrene (FG) is a rare necrotising soft tissue infection localised in the genital areas with possible dramatic outcomes. Recently, sodium glucose co-transporter-2 (SGLT2) inhibitors were identified as a risk factor. Methods: We present a case report of a 57-year-old female patient with type 2 diabetes mellitus (T2DM) in treatment with empagliflozin which led to the development of FG. Moreover, we performed a systematic review assessing the association between empagliflozin use and FG. Results: The female patient with 15-years treated diabetes presented a massive FG after 6 months from starting empagliflozin. Over the period of two months, she was successfully treated in a low-income setting. The systematic review included two studies with a total of 9915 participants. Although no participant had FG, there was an increased rate of urinary and genital infection in patients treated with empagliflozin compared to those treated with other antidiabetics or placebo. Conclusions: FG should be considered as a possible complication in patients using SGLT2. Patients should be educated to report early signs of genital infection and healthy behaviours as well as a balanced diet should be promoted to aid in the prevention of FG.

scholarly journals Fournier’s Gangrene in a Patient with Type 2 Diabetes Mellitus Treated with Empagliflozin: A Case Report

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Yasunori Nagano ◽  
Naomi Kashiwagi Yakame ◽  
Hisae Aoki ◽  
Tamaki Yamakawa ◽  
Naoko Iwahashi Kondo
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Case Report ◽  
Fournier’S Gangrene ◽  
Fournier's Gangrene

Fournier's gangrene as Amyand's hernia complication

2019 ◽  
Vol 98 (7) ◽  
pp. 291-296
Keyword(s):  
Case Report ◽  
Case Reports ◽  
Rare Condition ◽  
Sporadic Case ◽  
Fournier’S Gangrene ◽  
Amyand’S Hernia ◽  
Fournier's Gangrene ◽  
Randomized Controlled Studies ◽  
Based Medicine ◽  
Hernia Complication

Introduction: Fournier’s gangrene is a rare but fast deteriorating and serious condition with high mortality. In most cases, it is characterized as necrotizing fasciitis of the perineum and external genitals. Amyand’s hernia is a rare condition where the appendix is contained in the sac of an inguinal hernia. Inflammatory alterations in the appendix account only for 0.1 % of the cases when Amyand’s hernia is verified. Fournier’s gangrene as a complication of a late diagnosis of appendicitis located in the inguinal canal is described in the literature as rare case reports. Case report: The case report of a 70-year-old patient with Fournier’s gangrene resulting from gangrenous appendicitis of Amyand’s hernia. Conclusion: Fournier’s gangrene as a complication of Amyand’s hernia is a rare condition. Only sporadic case reports thereof can be found in the literature. Because of the rarity of this pathology and the lack of randomized controlled studies, it is difficult to determine the optimal treatment according to the principles of evidence-based medicine. An appropriate approach for this condition appears to be the combination of guidelines developed in Amyand’s therapy according to Losanoff and Basson, along with the recommended “gold standard” therapy for Fournier’s gangrene. This means early and highly radical surgical debridement, adequate antibiotic therapy and intensive care.

scholarly journals Fournier’s Gangrene in a Female Patient with Diabetes Mellitus: Report of a Case

2014 ◽  
Vol 5 (7) ◽  
pp. 206-208
Author(s):  
Gokhan Aksel ◽  
Betul Akbuga Ozel ◽  
Cemil Kavalci ◽  
Murat Muratoglu
Keyword(s):  
Diabetes Mellitus ◽  
Female Patient ◽  
Fournier’S Gangrene ◽  
Fournier's Gangrene

scholarly journals Vescicovaginal fistula management in low-income setting: a complicated case report

2019 ◽  
Vol 2019 (6) ◽  
Author(s):  
Igor Vaz ◽  
Lenny Starforth ◽  
Damiano Pizzol ◽  
Anna Claudia Colangelo
Keyword(s):  
Case Report ◽  
Low Income ◽  
Complicated Case ◽  
Low Income Setting

scholarly journals Sugar Sweetened Beverages Intake and Risk of Non-Communicable Chronic Diseases in Longitudinal Studies: A Systematic Review and Meta-Analysis with 1.5 Million Individuals

2021 ◽  
Author(s):  
Leonardo Pozza Santos ◽  
Denise Petrucci Gigante ◽  
Felipe Mendes Delpino ◽  
Ana Paula Maciel ◽  
Renata Moraes Bielemann
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Longitudinal Studies ◽  
Low Income ◽  
Meta Analysis ◽  
Sugar Sweetened Beverages ◽  
Sweetened Beverages

Abstract This study aimed to examine longitudinal associations between sugar-sweetened beverages (SSB) intake and type 2 diabetes, obesity, coronary heart disease and stroke in adults. We performed a systematic review and meta-analysis searching for articles in the Pubmed, Lilacs, Web of Science, Cochrane, Embase, and Scopus databases. After screening of titles and abstracts, 27 longitudinal studies were included for the narrative synthesis with all of them presenting medium or high methodological quality. None of the selected studies were from low-income countries and only three were conducted in middle-income countries. Type 2 diabetes was the most investigated disease – outcome in 15 out of 27 studies. Around 80% of the studies enrolled more than 10,000 individuals in the sample, and almost half of them followed the subjects for less than 10 years. A total of 1.5 million individuals were included in the pooled analyses, and results indicated that SSB intake increased the risk of type 2 diabetes (RR = 1.20; 95%C.I. 1.13 – 1.28), obesity (RR = 1.17; 95%C.I. 1.10 – 1.25), coronary heart disease (RR = 1.15; 95%C.I. 1.06 – 1.25), and stroke (RR = 1.10; 95%C.I. 1.01 – 1.19) in adults after adjustment for all potential confounders. Our systematic review and meta-analysis demonstrated that consumption of SSB intake appears to increase the risk non-communicable chronic disease, being the strongest evidence for type 2 diabetes. Actions are needed to be taken to reduce the SSB intake and its consequences worldwide.

scholarly journals Fournier’s gangrene mortality: A 17-year systematic review and meta-analysis

2020 ◽  
Vol 92 ◽  
pp. 218-225 ◽  
Author(s):  
Amr Ehab El-Qushayri ◽  
Khalid Muhammad Khalaf ◽  
Abdullah Dahy ◽  
Abdalla Reda Mahmoud ◽  
Amira Yasmine Benmelouka ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Fournier’S Gangrene ◽  
Fournier's Gangrene

Fournier's Gangrene of Genitalia: Case Report

2003 ◽  
Vol 70 (1-4) ◽  
pp. 38-40
Author(s):  
P. Salciccia ◽  
G. Poveromo ◽  
S. Salciccia
Keyword(s):  
Septic Shock ◽  
Case Report ◽  
Early Diagnosis ◽  
Rare Disease ◽  
Abdominal Wall ◽  
Sudden Onset ◽  
Fournier’S Gangrene ◽  
Fournier's Gangrene ◽  
Prodromal Symptoms

Fournier's gsngrene is a rare disease involving the scrotum and the penis with occasional extension up to the abdominal wall. The etiology of the disease, commonly without prodromal symptoms and with sudden onset, is still not fully understood. The organisms are usually streptococcus haemoliticus and/or anerobic bacteria. We report a case of Fournier's gangrene, presenting septic shock. The patient was treated with reanimatory care, antibiotics, local excision and debridment. Speaking about anatomical and etiopathogenetic hypotheses, we discuss the diagnostic problems and the treatment of the disease. We emphasize the role of the early diagnosis.

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