scholarly journals Effect of Botulinum Toxin Injection and Extracorporeal Shock Wave Therapy on Nerve Regeneration in Rats with Experimentally Induced Sciatic Nerve Injury

Toxins ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 879
Author(s):  
Minsu Seo ◽  
Dongin Lim ◽  
Shengshu Kim ◽  
Taeyeon Kim ◽  
Bum Sun Kwon ◽  
...  
Keyword(s):  
Shock Wave ◽  
Sciatic Nerve ◽  
Schwann Cells ◽  
Nerve Injury ◽  
Axonal Regeneration ◽  
Extracorporeal Shock Wave Therapy ◽  
Functional Improvement ◽  
Control Group ◽  
Shock Wave Therapy ◽  
Extracorporeal Shock Wave

This study was designed to compare the roles of botulinum neurotoxin A (BoNT/A) and extracorporeal shock wave therapy (ESWT) in promoting the functional recovery and regeneration of injured peripheral nerves. A total of 45 six-week-old rats with sciatic nerve injury were randomly divided into two experimental groups and one control group. The experimental groups received a single session of intranerve BoNT/A or ESWT immediately after a nerve-crushing injury. The control group was not exposed to any treatment. Differentiation of Schwann cells and axonal sprouting were observed through immunofluorescence staining, ELISA, real-time PCR, and Western blot at 3, 6, and 10 weeks post-nerve injury. For clinical assessment, serial sciatic functional index analysis and electrophysiological studies were performed. A higher expression of GFAP and S100β was detected in injured nerves treated with BoNT/A or ESWT. The levels of GAP43, ATF3, and NF200 associated with axonal regeneration in the experimental groups were also significantly higher than in the control group. The motor functional improvement occurred after 7 weeks of clinical observation following BoNT/A and ESWT. Compared with the control group, the amplitude of the compound muscle action potential in the experimental groups was significantly higher from 6 to 10 weeks. Collectively, these findings indicate that BoNT/A and ESWT similarly induced the activation of Schwann cells with the axonal regeneration of and functional improvement in the injured nerve.

scholarly journals COMPARISON OF SHORT-TERM ANALGESIC EFFECTS OF EXTRACORPOREAL SHOCK WAVE THERAPY (ESWT) AND CONSERVATIVE TREATMENT (CT) IN MEN WITH CHRONIC HEEL SPUR (HS).

2014 ◽  
Vol 1 (1) ◽  
Author(s):  
P. Lizis
Keyword(s):  
Shock Wave ◽  
Conservative Treatment ◽  
Extracorporeal Shock Wave Therapy ◽  
Control Group ◽  
Surgical Removal ◽  
Shock Wave Therapy ◽  
Short Term ◽  
Heel Spur ◽  
Analgesic Effects ◽  
Extracorporeal Shock Wave

<p><strong>Background.</strong> The surgical removal of heel spur (HS) provokes many controversial opinions, but clinical studies show the risk of complication after operation. An alternative to the surgical removal of HS is Extracorporeal Shock Wave Therapy (ESWT), because it is non-invasive method.<br /><strong>Objective.</strong> The aim of the study is to compare the short-term analgesic effects of ESWT and conservative treatment (CT) in males with chronic HS.<br /><strong>Methods.</strong> Sixty patients (mean age 54.9±4.3 years; range 42 to 59 years) were examined who had pain associated with HS. In the shockwave group (group 1) patients received 1000–2000 impulses of shocks to the affected heel in a single session. The patients in this group took a series of 5 ESWT in 1 week intervals. Patients in the control group (group 2) at the same time received CT consisting of nonsteroidal anti-inflammatory drugs (NSAIDs), orthotics and a local cortisone injection. The basic method of research was to evaluate pain according to Visual Analogue Scale (VAS) 0–10. The patients of the two groups were tested before the treatment, after the last treatment and 3 months and 6 months after the treatment.<br /><strong>Results.</strong> A significant decrease of VAS (p=0.000) was seen in the shockwave group. In the control group no significant decrease of VAS was seen.<br /><strong>Conclusions.</strong> ESWT reduces pain more effectively than CT in men with chronic HS.</p><p><br /><strong>KEY WORDS:</strong> extracorporeal shock wave therapy, conservative treatment, visual analogue scale, heel spur, pain.</p>

scholarly journals Two methods of extracorporeal shock-wave therapy in a rat model of secondary lymphedema: a pilot study

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110244
Author(s):  
Hee Kyung Cho ◽  
Woo Jung Sung ◽  
Youn Ju Lee ◽  
Sang Gyu Kwak ◽  
Kang Lip Kim
Keyword(s):  
Shock Wave ◽  
Rat Model ◽  
Growth Factor Receptor ◽  
Extracorporeal Shock Wave Therapy ◽  
Control Group ◽  
Axillary Lymph ◽  
Sprague Dawley ◽  
Shock Wave Therapy ◽  
Secondary Lymphedema ◽  
Extracorporeal Shock Wave

Objectives To compare the effectiveness of two methods of extracorporeal shock-wave therapy (ESWT) in a rat model of forelimb lymphedema, induced by axillary lymph node dissection. Methods Sprague–Dawley rats were randomly allocated to a group that received 500 ESWT shocks only in the lymphedematous forelimb (Forelimb/ESWT) and a group that received 300 ESWT shocks in the axilla and 200 shocks in the lymphedematous forelimb (Axilla+Forelimb/ESWT). The circumferences of each limb were then measured. Immunohistochemistry for a pan-endothelial marker (cluster of differentiation [CD]31) and lymphatic vessel endothelial hyaluronan receptor-1, and western blot analysis for vascular endothelial growth factor receptor-3 (VEGFR3) and VEGF-C were performed. Results The circumferences of the limbs showed significant effects of group and time following surgery. The circumferences at the carpal joint and 2.5 cm above were smallest in the naïve limbs, larger in the Axilla+Forelimb/ESWT group, and the largest in the control group. VEGFR3 tended to be expressed at a higher level in the Axilla+Forelimb/ESWT group (1.96-fold) than in the Forelimb/ESWT group (1.20-fold) versus the opposite non-edematous forelimbs, although this difference was not statistically significant. Conclusions These data suggest that ESWT protocols have differential effects on angiogenesis and lymphangiogenesis in lymphedematous limbs.

scholarly journals Evaluation of plantar fasciitis improvement after shock wave therapy in calcaneal spur patients by musculoskeletal ultrasonography

2021 ◽  
Vol 48 (1) ◽  
Author(s):  
Soad Said El Molla ◽  
Ahmed M. Fahmy ◽  
Amr Mohamed Gamil ◽  
Rehab Ali Ibrahim ◽  
Mai Mohamed Kamel
Keyword(s):  
Shock Wave ◽  
Plantar Fasciitis ◽  
Functional Disability ◽  
Therapeutic Option ◽  
Plantar Fascia ◽  
Extracorporeal Shock Wave Therapy ◽  
Control Group ◽  
Shock Wave Therapy ◽  
Calcaneal Spur ◽  
Extracorporeal Shock Wave

Abstract Background Plantar fasciitis due to calcaneal spur is a common cause of heel pain and functional disability, and its management presents a huge challenge for clinicians which results sometimes in unpleasant clinical outcomes. The efficacy of extracorporeal shock wave therapy (ESWT) as an alternative therapeutic option to surgical management after failure of conservative treatment has been addressed. Our aim was to evaluate the efficacy of ESWT in the treatment of plantar fasciitis in calcaneal spur patients using ultrasonography. Results The mean plantar fascia (PF) thickness was statistically significantly higher in the calcaneal spur patient group (5.66 ± 1.14 mm) than in the healthy control group (2.40 ± 0.35 mm), (P = 0.001). Significant PF thickness reduction, visual analog scale (VAS), and Roles and Maudsley score (RMS) improvement were observed (P < 0.001) after 4 sessions of ESWT. Conclusion PF thickness increases significantly in calcaneal spur patients and responds to treatment. ESWT decreases the thickness of the PF and improves pain and function significantly.

scholarly journals Extracorporeal Shock Wave Therapy for Lateral Epicondylitis, Lonely or in Combination with Topical Corticosteroid; Which Approach is Superior?

2020 ◽  
Vol 9 ◽  
pp. 1791
Author(s):  
Babak Vahdatpour ◽  
Parisa Taheri ◽  
Fatemeh Abasi
Keyword(s):  
Shock Wave ◽  
Topical Corticosteroid ◽  
Tennis Elbow ◽  
Intervention Group ◽  
Lateral Epicondylitis ◽  
Extracorporeal Shock Wave Therapy ◽  
Control Group ◽  
Topical Steroids ◽  
Shock Wave Therapy ◽  
Extracorporeal Shock Wave

Background: Lateral epicondylitis (LE) is a common musculoskeletal disorder. Although varieties of modalities have been proposed for its treatment, the outcomes are uncertain, and the responses would diminish early by the time passage. The current study was aimed to assess the efficacy of extracorporeal shock wave therapy (ESWT) merely and in combination with topical corticosteroid for the treatment of LE. Materials and Methods: In the current double-blinded randomized clinical trial, 70 patients with the diagnosis of LE were randomly allocated to two intervention groups of ESWT merely (control group) (n=35) or ESWT plus topical corticosteroid (intervention group) (n=35). The ESWT was performed weekly for three weeks. Topical clobetasol was utilized within 30 minutes before ESWT for the intervention group, while Vaseline gel was used in a similar pattern for controls. Pain based on a visual analog scale (VAS), handgrip strength (HGS) and the Patient-Rated Tennis Elbow Evaluation (PRTEE) were assessed for the patients before the intervention, following the intervention cessation, and within two months post-intervention. Results: Statistically significant improvement was found following both interventions in terms of pain, HGS, and function (P-value0.05). Conclusion: The findings of our study are in favor of ESWT use either merely or in combination with topical steroids for the treatment of LE, while the comparison of the two techniques revealed insignificant differences. [GMJ.2020;9:e1791]

scholarly journals Effectiveness of focused extracorporeal shock wave therapy in the treatment of carpal tunnel syndrome

2020 ◽  
Author(s):  
Christina Gesslbauer ◽  
Michael Mickel ◽  
Othmar Schuhfried ◽  
Dominikus Huber ◽  
Mohammad Keilani ◽  
...  
Keyword(s):  
Shock Wave ◽  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Extracorporeal Shock Wave Therapy ◽  
Control Group ◽  
Study Group ◽  
Shock Wave Therapy ◽  
Extracorporeal Shock Wave ◽  
Sf 36 ◽  
Tunnel Syndrome

Summary Background The carpal tunnel syndrome is the most common entrapment neuropathy in the general population. A conservative treatment should be considered in mild to moderate cases. The aim of this study was to assess the effect of a focused extracorporeal shock wave therapy in the treatment of mild to moderate carpal tunnel syndrome. Material and Methods In this study 30 patients were randomly assigned into 2 groups. Subjects in the study group received three sessions of focused extracorporeal shock wave therapy, whereas the control group underwent a sham therapy. Patients were evaluated 3 and 12 weeks after treatment. The primary outcome was the visual analogue scale score. Secondary outcome measurements included hand grip strength, Boston Carpal Tunnel Syndrome Questionnaire, SF-36 Health Survey and electrodiagnostic measurements. Results A significant improvement of visual analogue scale at week 3 (p = 0.018) and week 12 (p = 0.007) as well as hand grip strength at week 12 (p = 0.019) could be observed in the study group. The study group showed a significantly better sensory nerve conduction velocity at week 12 than the control group, before correcting for multiple testing, and also a significant improvement in distal motor latency of the median nerve at week 12 (p = 0.009) as well as in both questionnaires (SF-36 subscale bodily pain, p = 0.020 and severity symptom scale, p = 0.003). No such improvement was observed in the control group. Conclusion Focused extracorporeal shock wave therapy is an effective and noninvasive treatment method for mild to moderate carpal tunnel syndrome.

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