scholarly journals Acute Late-Stage Myocarditis in the Crab-Eating Macaque Model of Hemorrhagic Smallpox

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1571
Author(s):  
Reed F. Johnson ◽  
Lauren A. Keith ◽  
Timothy K. Cooper ◽  
Srikanth Yellayi ◽  
Nicole M. Josleyn ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Late Stage ◽  
Human Disease ◽  
Cowpox Virus ◽  
Variola Virus ◽  
Disease Manifestation ◽  
Cardiac Pathology ◽  
Secondary Bacterial Infection ◽  
Macaque Model

Hemorrhagic smallpox, caused by variola virus (VARV), was a rare but nearly 100% lethal human disease manifestation. Hemorrhagic smallpox is frequently characterized by secondary bacterial infection, coagulopathy, and myocardial and subendocardial hemorrhages. Previous experiments have demonstrated that intravenous (IV) cowpox virus (CPXV) exposure of macaques mimics human hemorrhagic smallpox. The goal of this experiment was to further understand the onset, nature, and severity of cardiac pathology and how it may contribute to disease. The findings support an acute late-stage myocarditis with lymphohistiocytic infiltrates in the CPXV model of hemorrhagic smallpox.

Herpetic Whitlow of the Hand in Infants

2020 ◽  
Author(s):  
Mohammad M. Al-Qattan ◽  
Nada G. AlQadri ◽  
Ghada AlHayaza
Keyword(s):  
Bacterial Infection ◽  
Case Reports ◽  
Case Series ◽  
Individual Case ◽  
Senior Author ◽  
Secondary Bacterial Infection ◽  
Clinical Appearance ◽  
History Of ◽  
Mode Of Transmission ◽  
Time Of Presentation

Abstract Introduction Herpetic whitlows in infants are rare. Previous authors only reported individual case reports. We present a case series of six infants. Materials and Methods This is a retrospective study of six cases of herpetic whitlows in infants seen by the senior author (MMA) over the past 23 years (1995–2017 inclusive). The following data were collected: age, sex, digit involved in the hand, mode of transmission, time of presentation to the author, clinical appearance, presence of secondary bacterial infection, presence of other lesions outside the hand, method of diagnosis, treatment, and outcome. Results All six infants initially presented with classic multiple vesicles of the digital pulp. In all cases, there was a history of active herpes labialis in the mother. Incision and drainage or deroofing of the vesicles (for diagnostic purposes) resulted in secondary bacterial infection. Conclusion The current report is the first series in the literature on herpetic whitlows in infants. We stress on the mode of transmission (from the mother) and establishing the diagnosis clinically. In these cases, no need for obtaining viral cultures or polymerase chain reaction; and no medications are required. Once the vesicles are disrupted, secondary bacterial infection is frequent and a combination of oral acyclovir and intravenous antibiotics will be required.

scholarly journals Is Topical or Systemic Antimicrobial Therapy More Effective for the Treatment of Feline Acne With Secondary Bacterial Infection?

2018 ◽  
Vol 3 (3) ◽  
Author(s):  
Wendy Kwok ◽  
Kate Charlotte Mellor
Keyword(s):  
Open Access ◽  
Bacterial Infection ◽  
Antimicrobial Therapy ◽  
Systemic Treatment ◽  
Clinical Signs ◽  
Sufficient Evidence ◽  
Bottom Line ◽  
Secondary Bacterial Infection

<strong>PICO question</strong><br /><p>In cats with feline acne and secondary bacterial folliculitis or furunculosis, is topical or systemic antimicrobial therapy superior for reducing time to resolution and severity of clinical signs?</p><strong>Clinical bottom line</strong><br /><p>There is no sufficient evidence to compare topical versus systemic treatment in feline acne with secondary folliculitis/furunculosis.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

Complications of Smallpox Vaccination, 1968 Surveillance in a Comprehensive Care Clinic

PEDIATRICS ◽  
1972 ◽  
Vol 50 (3) ◽  
pp. 481-483
Author(s):  
John M. Neff ◽  
Robert H. Drachman
Keyword(s):  
Bacterial Infection ◽  
Comprehensive Care ◽  
Smallpox Vaccination ◽  
Age Group ◽  
Care Clinic ◽  
Secondary Bacterial Infection ◽  
Group 1

The records of all children who received smallpox vaccination in a large comprehensive care clinic were reviewed for complications. There were 944 vaccinations performed during 1968. Of these, 539 were primary vaccinations, 32 on children in the age group less than 1, and 517 on children in the age group 1 to 4. There were nine complications observed, all in children in the age group 1 to 4. Five of these complications were generalized erythematous urticarial eruptions, three were auto-inoculations, and one was a secondary bacterial infection at the site of vaccination.

Is There Evidence That Antibiotics Prevent Oral Infections?

PEDIATRICS ◽  
1975 ◽  
Vol 55 (2) ◽  
pp. 294-294
Author(s):  
William T. Speck
Keyword(s):  
Bacterial Infection ◽  
Secondary Infection ◽  
Secondary Bacterial Infection ◽  
Oral Infections ◽  
Herpetic Gingivostomatitis

Dr. Alan M. Polson's article on gingival and periodontal problems in children was most informative.1 However, I found the last sentence somewhat puzzling, i.e., "Antibiotics are a help in preventing secondary infection." I wonder if the author could (1) provide evidence to substantiate his suggestion that secondary bacterial infection occur with acute herpetic gingivostomatitis and (2) substantiate his claim that antibiotics prevent such a complication?

Poxviruses

2010 ◽  
pp. 508-512
Author(s):  
Geoffrey L. Smith
Keyword(s):  
Vaccinia Virus ◽  
Human Disease ◽  
Biological Science ◽  
Cowpox Virus ◽  
Dna Viruses ◽  
Large Complex ◽  
Global Eradication ◽  
Human Vaccine

Poxviruses are large, complex DNA viruses that have played several seminal roles in medicine and biological science. Cowpox virus was introduced by Jenner as the first human vaccine in 1796; widespread vaccination with vaccinia virus led to the global eradication of smallpox in 1977, the only human disease to have been eradicated....

Secondary Bacterial Infection of a Solitary Cysticercus Granuloma

2020 ◽  
Vol 68 (3) ◽  
pp. 684
Author(s):  
AriGeorge Chacko ◽  
AnanthP Abraham ◽  
MandeepSingh Bindra
Keyword(s):  
Bacterial Infection ◽  
Secondary Bacterial Infection

Mixed secondary bacterial infection is associated with severe lesions of chromoblastomycosis in a neglected population from Brazil

2019 ◽  
Vol 95 (2) ◽  
pp. 201-207
Author(s):  
Sirlei G. Marques ◽  
Maria Rosa Q. Bomfim ◽  
Conceição de Maria P.S. Azevedo ◽  
Cleide Viviane B. Martins ◽  
Ana Claudia G. Marques ◽  
...  
Keyword(s):  
Bacterial Infection ◽  
Secondary Bacterial Infection

scholarly journals Guide snoRNAs: Drivers or Passengers in Human Disease?

Biology ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. 1 ◽  
Author(s):  
Manisha Deogharia ◽  
Mrinmoyee Majumder
Keyword(s):  
Protein Interactions ◽  
Human Disease ◽  
Critical Role ◽  
Mrna Translation ◽  
Causal Link ◽  
Rna Modification ◽  
Disease Manifestation ◽  
The Stability ◽  
Nucleoside Modification ◽  
Host Genes

In every domain of life, RNA-protein interactions play a significant role in co- and post-transcriptional modifications and mRNA translation. RNA performs diverse roles inside the cell, and therefore any aberrancy in their function can cause various diseases. During maturation from its primary transcript, RNA undergoes several functionally important post-transcriptional modifications including pseudouridylation and ribose 2′-O-methylation. These modifications play a critical role in the stability of the RNA. In the last few decades, small nucleolar RNAs (snoRNAs) were revealed to be one of the main components to guide these modifications. Due to their active links to the nucleoside modification, deregulation in the snoRNA expressions can cause multiple disorders in humans. Additionally, host genes carrying snoRNA-encoding sequences in their introns also show differential expression in disease. Although few reports support a causal link between snoRNA expression and disease manifestation, this emerging field will have an impact on the way we think about biomarkers or identify novel targets for therapy. This review focuses on the intriguing aspect of snoRNAs that function as a guide in post-transcriptional RNA modification, and regulation of their host genes in human disease.

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