The study of NMR spectroscopy use in pharmaceutical analysis

2021 ◽  
pp. 73-78
Author(s):  
Maria N. Kuznetsova ◽  
Vera Yu. Zhilkina
Keyword(s):  
Quality Assurance ◽  
Nmr Spectroscopy ◽  
Pharmaceutical Analysis ◽  
Drug Products ◽  
Synthetic Drugs ◽  
Highly Active ◽  
Drugs Analysis ◽  
Active Substances ◽  
Natural And Synthetic

Drug products are specific goods. A customer cannot determine quality and authenticity of any tablet, ointment or ampule content himself. As number of registered drugs has been increasing the actuality of quality assurance and standardization of drugs becomes much important. At the same time highly active substances belonging to new natural and synthetic drugs classes has been coming in medicinal practice. NMR spectroscopy approach has wide opportunities in increasing number of drugs analysis which must meet constantly increasing demands.

Natural and Synthetic Drugs

Nature ◽  
1951 ◽  
Vol 168 (4272) ◽  
pp. 438-439
Author(s):  
J. W. COOK
Keyword(s):  
Synthetic Drugs ◽  
Natural And Synthetic

scholarly journals The Application of NMR Spectroscopy and Chemometrics in Authentication of Spices

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 382
Author(s):  
Barbara Pacholczyk-Sienicka ◽  
Grzegorz Ciepielowski ◽  
Łukasz Albrecht
Keyword(s):  
Quality Assurance ◽  
Nmr Spectroscopy ◽  
Sample Preparation ◽  
Bioactive Compounds ◽  
Analytical Methods ◽  
Structural Information ◽  
Chemometric Analysis ◽  
Spectroscopic Methods ◽  
Regular Consumption ◽  
No Sample Preparation

Spices and herbs are among the most commonly adulterated food types. This is because spices are widely used to process food. Spices not only enhance the flavor and taste of food, but they are also sources of numerous bioactive compounds that are significantly beneficial for health. The healing effects of spices are connected with their antimicrobial, anti-inflammatory and carminative properties. However, regular consumption of adulterated spices may cause fatal damage to our system because adulterants in most cases are unhealthy. For that reason, the appropriate analytical methods are necessary for quality assurance and to ensure the authenticity of spices. Spectroscopic methods are gaining interest as they are fast, require little or no sample preparation, and provide rich structural information. This review provides an overview of the application of NMR spectroscopy combined with chemometric analysis to determine the quality and adulteration of spices.

A chemoinformatic analysis of atoms, scaffolds and functional groups in natural products

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Joelle Ngo Hanna ◽  
Boris D. Bekono ◽  
Luc C. O. Owono ◽  
Flavien A. A. Toze ◽  
James A. Mbah ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Physicochemical Properties ◽  
Functional Groups ◽  
Atomic Composition ◽  
Synthetic Compounds ◽  
Chemical Libraries ◽  
Synthetic Drugs ◽  
Drugs Analysis ◽  
Chemical Class

Abstract In the quest to know why natural products (NPs) have often been considered as privileged scaffolds for drug discovery purposes, many investigations into the differences between NPs and synthetic compounds have been carried out. Several attempts to answer this question have led to the investigation of the atomic composition, scaffolds and functional groups (FGs) of NPs, in comparison with synthetic drugs analysis. This chapter briefly describes an atomic enumeration method for chemical libraries that has been applied for the analysis of NP libraries, followed by a description of the main differences between NPs of marine and terrestrial origin in terms of their general physicochemical properties, most common scaffolds and “drug-likeness” properties. The last parts of the work describe an analysis of scaffolds and FGs common in NP libraries, focusing on huge NP databases, e.g. those in the Dictionary of Natural Products (DNP), NPs from cyanobacteria and the largest chemical class of NP – terpenoids.

scholarly journals Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids

2011 ◽  
Vol 10 (5) ◽  
pp. 86-90
Author(s):  
N. A. Pulina ◽  
A. I. Krasnova ◽  
F. V. Sobin ◽  
T. A. Yushkova ◽  
V. V. Yushkov
Keyword(s):  
Bromine Atom ◽  
Hypoglycemic Activity ◽  
Reference Drug ◽  
Highly Active ◽  
Pharmaceutical Substances ◽  
Directed Synthesis ◽  
Low Toxic ◽  
Heterocyclic Moiety ◽  
Active Substances

The paper deals with directed synthesis and study of hypoglycemic activity of N-heterylamides of 4-aryl-2-hydroxy-4-oxo-2- butenoic and 4-aryl-3-bromo-2, 4-dioxobutanoic acids. Hypoglycemic activity of 28 compounds was under research. Some regularities of the influence of the heterocyclic moiety structure and the bromine atom on the activity of the compounds were obtained. Two low-toxic and highly active substances comparable in potency with the reference drug were identified.

Configurational Assignment of D- and L-Isovalines in Intact, Natural, and Synthetic Peptides by 2D-NMR Spectroscopy

2010 ◽  
Vol 7 (6) ◽  
pp. 1612-1624 ◽  
Author(s):  
Marta De Zotti ◽  
Elisabetta Schievano ◽  
Stefano Mammi ◽  
Bernard Kaptein ◽  
Quirinus B. Broxterman ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Synthetic Peptides ◽  
2D Nmr ◽  
2D Nmr Spectroscopy ◽  
Configurational Assignment ◽  
Natural And Synthetic

scholarly journals Validation and Quality Assurance of Planar Chromatographic Procedures in Pharmaceutical Analysis

2001 ◽  
Vol 84 (4) ◽  
pp. 1265-1276 ◽  
Author(s):  
Katalin Ferenczi-Fodor ◽  
Zoltán Végh ◽  
Anikó Nagy-Turák ◽  
Bernd Renger ◽  
Marco Zeller
Keyword(s):  
Quality Assurance ◽  
Pharmaceutical Analysis ◽  
Control Charts ◽  
Practical Experience ◽  
Standardized Terminology ◽  
Criteria For Evaluation ◽  
Formal Requirements ◽  
Determination Of Impurities ◽  
Validation Experiments

Abstract Within the process of the International Conference on Harmonization (ICH), 2 guidelines were released containing a standardized terminology, a verified model of requirements for the validation of analytical procedures, and some guidance in the practical aspects of conducting validation studies in pharmaceutical analysis. For planar chromatographic procedures, which may be used at different levels either in qualitative identity testing, assays, semiquantitative limit tests, or quantitative determination of impurities, this paper tries to transfer these formal requirements into practical approaches for validation. Basic acceptance criteria for evaluation of validation experiments based on practical experience are proposed. In addition, selected parameters for robustness testing of given procedures and quality assurance of quantitative planar chromatographic testing by control charts is described.

Natural and synthetic drugs used for the treatment of the dementia

2020 ◽  
Vol 524 (3) ◽  
pp. 772-783 ◽  
Author(s):  
Valery M. Dembitsky ◽  
Lilya Dzhemileva ◽  
Tatyana Gloriozova ◽  
Vladimir D’yakonov
Keyword(s):  
Synthetic Drugs ◽  
Natural And Synthetic

scholarly journals Structural Elucidation of Pimarane and Isopimarane Diterpenoids: The 13C NMR Contribution

2008 ◽  
Vol 3 (3) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Ana M. L. Seca ◽  
Diana C. G. A. Pinto ◽  
Artur M. S. Silva
Keyword(s):  
Nmr Spectroscopy ◽  
13C Nmr ◽  
Nmr Assignments ◽  
Structural Elucidation ◽  
Synthetic Compounds ◽  
Chiral Centers ◽  
Pimarane Diterpenoids ◽  
Biosynthetic Studies ◽  
C Nmr ◽  
Natural And Synthetic

13C NMR spectroscopy is actually one of the first tools used for the structural elucidation of natural and synthetic compounds and it is also used in biosynthetic studies. The aim of this review is to present the 13C NMR assignments of a large number of pimarane diterpenoids, describing the most significant effects caused by different substitution patterns and different stereochemistry at their chiral centers.

scholarly journals From Pharmacognosia to DNA-Based Medicinal Plant Authentication – Pharmacognosy through the Centuries

Planta Medica ◽  
2017 ◽  
Vol 83 (14/15) ◽  
pp. 1110-1116 ◽  
Author(s):  
Michael Heinrich ◽  
Sabine Anagnostou
Keyword(s):  
Quality Assurance ◽  
Medicinal Plants ◽  
19Th Century ◽  
18Th Century ◽  
Herbal Medicines ◽  
Essential Element ◽  
Scientific Methods ◽  
Materia Medica ◽  
The 19Th Century ◽  
Active Substances

AbstractFor centuries, pharmacognosy was essential for the identification, quality, purity, and, until the end of the 18th century, even for the efficacy of medicinal plants. Since the 19th century, it concentrated on authenticity, purity, quality and the analysis of active substances, and was established as an academic branch discipline within pharmacy and continuously developed into a modern, highly sophisticated science. Even though the paradigm in pharmacy changed in the 19th century with the discovery of morphine and concentrated on single substances that could be synthesized fast by the upcoming industry, medicinal plants always remained an important element of the Materia medica, and during the last decades, medicinal plants continue to be a source of remedies, and natural products are an inspiration for new medicine. In this research, pharmacognostic skills remain an essential element, both with regards to identity, quality assurance of botanicals (both herbal medicines and supplements), and the discovery and development of new medicines. Over the years, the specific pharmacognostical tools have changed dramatically, and most recently, DNA-based techniques have become another element of our spectrum of scientific methods.

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