Immune cells of the epithelial ovarian cancer microenvironment

2021 ◽  
pp. 67-78
Author(s):  
Varvara Nikolaevna Zhurman ◽  
Natalia Gennadevna Plekhova ◽  
Ekaterina Valeryevna Eliseeva
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Immune Cells ◽  
Ovarian Tumor ◽  
Biologically Active ◽  
Cancer Microenvironment ◽  
Review Of The Literature ◽  
Prognostic Role ◽  
Active Substances

The article is a review of the literature, which analyzes the data on the role of cells of the immune system, cytokines and other biologically active substances secreted by them in the interstitial space of an ovarian tumor. The emphasis is made on the mechanism of realization by immune cells of the stimulating and suppressing action on the development of the tumor. Considerable attention is paid to the prognostic role of immune cells in the development of epithelial ovarian cancer.

scholarly journals The prognostic role of microRNA in epithelial ovarian cancer: a systematic review of literature with an overall survival meta-analysis

Oncotarget ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1085-1095 ◽  
Author(s):  
Patricia Ferreira ◽  
Rosimeire Aparecida Roela ◽  
Rossana Veronica Mendoza Lopez ◽  
Maria Del Pilar Estevez-Diz
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Overall Survival ◽  
Epithelial Ovarian Cancer ◽  
Meta Analysis ◽  
Review Of Literature ◽  
Prognostic Role

Prognostic Role of CA-125 Nadir in Stage IV Epithelial Ovarian Cancer

2008 ◽  
Vol 26 (10) ◽  
pp. 1771-1772 ◽  
Author(s):  
Aleix Prat ◽  
Marta Parera ◽  
Josep Maria Del Campo
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Stage Iv ◽  
Ca 125 ◽  
Prognostic Role

scholarly journals Prognostic role of excision repair cross complementing-1 and topoisomerase-1 expression in epithelial ovarian cancer

2016 ◽  
Vol 55 (2) ◽  
pp. 213-219 ◽  
Author(s):  
Shih-Chieh Liu ◽  
Hao Lin ◽  
Chao-Cheng Huang ◽  
Chan-Chao Chang Chien ◽  
Ching-Chou Tsai ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Excision Repair ◽  
Prognostic Role ◽  
Topoisomerase 1

Elevated CA125 level associated with Meigs' syndrome: case report and review of the literature

2006 ◽  
Vol 16 (Suppl 1) ◽  
pp. 315-318 ◽  
Author(s):  
A. Morán-Mendoza ◽  
G. Alvarado-Luna ◽  
G. Calderillo-Ruiz ◽  
A. Serrano-Olvera ◽  
C. M. LÓPEZ-GRANIEL ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Pleural Effusion ◽  
Epithelial Ovarian Cancer ◽  
Ovarian Tumor ◽  
Tumor Volume ◽  
Review Of The Literature ◽  
Marked Elevation ◽  
Ca125 Level ◽  
Total Lack ◽  
Histopathologic Analysis

Meigs' syndrome is the association of ovarian fibroma, pleural effusion, and ascites. Meigs' syndrome with marked elevation of CA125 is an unusual clinical condition reported in 27 cases in the literature. The patient was a 46-year-old woman with right pleural effusion, ascites, ovarian tumor, and CA125 level of 1808 U/mL. Tomography revealed ascites and bilobate pelvic tumor of approximately 25 cm. The diagnosis of advanced epithelial ovarian cancer was considered, and the patient was treated with chemotherapy. Three chemotherapy schemes were applied due to the total lack of response in tumor volume; however, CA125 decreased to 90 U/mL. Thus, surgery was performed with resection of 25 cm of the left ovarian tumor, with intact capsule and without implants; the result of histopathologic analysis was fibroma. Postoperative CA125 was 11 U/mL. Patients with elevated CA125 and ascites cytology positive for malignancy must be cautiously treated due to the possibility of false positives, even if the probability is low. Therefore, minimally invasive surgery for biopsy collection must be considered. Although the association between ovarian tumor, pleural effusion, ascites, and marked elevation of CA125 is highly indicative of epithelial ovarian cancer, Meigs' syndrome must be considered in the differential diagnosis.

scholarly journals Prognostic Characteristics of MACC1 Expression in Epithelial Ovarian Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Hoiseon Jeong ◽  
Jiyoon Jung ◽  
Hwa Eun Oh ◽  
Jung-Woo Choi ◽  
Eung Seok Lee ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Progression Free Survival ◽  
Prognostic Role ◽  
Normal Surface ◽  
Free Survival ◽  
Oncomine Database ◽  
Kaplan Meier ◽  
Survival Effect

Recent studies have shown that overexpression of metastasis-associated in colon cancer 1 (MACC1) is significantly associated with adverse prognoses of patients with different kinds of cancer. However, the exact survival effect of MACC1 on epithelial ovarian cancer (EOC) patients has not yet been established. Thus, the objective of this study was to explore the prognostic role of MACC1 mRNA in EOC by using Kaplan-Meier (KM) plotter and ONCOMINE database. Our results indicated that MACC1 mRNA high expression was significantly associated with unfavorable overall survival (hazard ratio (HR) = 1.51 (95% confidence interval (CI): 1.21 – 1.88), P = 0.00025) and progression-free survival (HR = 1.53 (95% CI: 1.24 – 1.89), P = 5.8e-05) in EOC patients. We also found that the expression of MACC1 mRNA in EOC was 2.5 times higher than that in normal surface ovarian epithelium, which was statistically significant (P = 2.86e-7). Our results suggest that MACC1 expression might be a biomarker for poor prognosis in individual EOC patients.

Sign in / Sign up

Export Citation Format

Share Document