scholarly journals St John's wort (Hypericum perforatum L.): A Review of its Chemistry, Pharmacology and Clinical properties

2018 ◽  
Vol 1 (1) ◽  
pp. 5-11 ◽  
Author(s):  
AR Mullaicharam ◽  
Nirmala Halligudi
Keyword(s):  
Hypericum Perforatum ◽  
The United States ◽  
Supporting Evidence ◽  
Antibacterial Effects ◽  
Pharmacological Activities ◽  
Perennial Plant ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L ◽  
Herbaceous Perennial

St John's wort (also known as hypericum, millepertuis) is Hypericum perforatum L., Hypericaceae, an herbaceous perennial plant native to Europe and Asia, and which has been introduced into the United States where it has naturalized (38). The chemical composition of St. John's wort has been well-studied. Documented pharmacological activities, including antidepressant, antiviral, and antibacterial effects, provide supporting evidence for several of the traditional uses stated for St John's wort. Many pharmacological activities appear to be attributable to hypericin and to the flavanoid constituents; hypericin is also reported to be responsible for the photosensitive reactions that have been documented for St. John's wort. This systematic review overviews the literature on the use of St. John’s Wort for chemistry, pharmacology and clinical properties.

St. John's Wort versus Counterfeit St. John's Wort: An HPTLC Study

2016 ◽  
Vol 99 (5) ◽  
pp. 1204-1212 ◽  
Author(s):  
Débora A Frommenwiler ◽  
Eike Reich ◽  
Sidney Sudberg ◽  
Maged H M Sharaf ◽  
Anton Bzhelyansky ◽  
...  
Keyword(s):  
Hypericum Perforatum ◽  
The United States ◽  
Reversed Phase ◽  
Synthetic Dyes ◽  
St John’S Wort ◽  
St John's Wort ◽  
Detection Mode ◽  
Hypericum Perforatum L ◽  
States Pharmacopeia ◽  
Hptlc Method

Abstract Hypericum perforatum L. is the most commonly used herb for treating depression. Due to the popularity of this botanical, there is a potential for economically driven adulteration of St. John's wort (SJW) products. The goal of this study was to investigate SJW ingredients suspected to be adulterated based on simple preliminary HPTLC tests. Commercial samples were analyzed by HPTLC following the United States Pharmacopeia (USP) monograph methodology, with additional visualization under white light. A number of these samples presented odd methanolic solution colors and unconventional HPTLC fingerprints, suggesting the presence of other species and/or extraneous polar additives. To achieve identification and separation of the polar additives, a new reversed-phase HPTLC method was developed. The adulterants were identified as synthetic dyes in the amounts of 0.51 to 1.36% by weight. Identities of the dyes were confirmed by scanning densitometry and HPTLC-MS. A modified USP method with additional detection mode permitted the identification of eight SJW samples adulterated with dyes and six others with flavonoid fingerprints different from those specified by USP from a total of 37 samples of dry extracts, finished products, and bulk raw herb. A decision flowchart is proposed to guide the detection of adulteration of SJW in a systematic fashion.

scholarly journals Distribution of total phenols, flavonoids and hypericin in different plant organs of wild-growing St. John’s-wort (Hypericum perforatum L., Hypericaceae) from North Macedonia

2019 ◽  
Vol 65 (2) ◽  
pp. 39-47
Author(s):  
Arijeta Shabania ◽  
Marija Karapandzova ◽  
Ivana Cvetkovikj Karanfilova ◽  
Gjoshe Stefkov ◽  
Maja Simonoska Crcarevska ◽  
...  
Keyword(s):  
Hypericum Perforatum ◽  
Total Flavonoids ◽  
Total Phenols ◽  
Pharmacological Activities ◽  
Plant Organs ◽  
Spectrophotometric Methods ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L ◽  
Made In

Hypericum perforatum L. (Hypericaceae) contains secondary metabolites that show noteworthy pharmacological activities. Therefore, the content of total phenols, flavonoids and hypericin from whole herb, flowers and leafs from St. John’s-wort collected over four consecutive seasons (2014-2017) from three different locations in western part of North Macedonia (Tetovo, Debar and Mavrovo) were investigated by three different spectrophotometric methods (using Folin-Ciocalteu reagent, NaNO2-AlCl3-NaOH and mixture of water/tetrahydrofuran). The quantity of total phenols obtained from different plant organs (leafs, whole herb and flowers) were 35.15-83.08 mg GAE/g, 55.41-98.52 mg GAE/g and 75.44-121.19 mg GAE/g, respectively. Afterword the total flavonoids contents were: 61.64-106.86 mg CE/g, 73.04-117.57 mg CE/g and 108.65-125.35 mg CE/g in leafs, whole herb and flowers, respectively, while the hypericin amounts were: 0.03-0.17 mg/g, 0.04-0.29 mg/g and 0.07-0.60 mg/g in leafs, whole herb, and flowers, respectively. Significant differences were observed in the quantities of total phenols, flavonoids and hypericin between the locations of harvesting, while the collection seasons were found not to be significant. Additionally, it can be seen that the flowers are characterized by higher amounts of total phenols, total flavonoids and hypericin compared to total herb and leaf in all three locations, therefore harvesting of St. John’s-wort should be made in a manner of obtaining larger quantities of flowers as harvesting material which could increase the bioactive compounds in the herbal row material. Keywords: Hypericum perforatum, plant organs, total phenols, flavonoids, hypericin, statistical analysis

Determination of Hypericin in St. John's Wort (Hypericum perforatum L.) extracts using HPLC-ED

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
E Sofic ◽  
A Copra Janicijevic ◽  
M Maksimovic ◽  
I Tahirovic ◽  
L Klepo ◽  
...  
Keyword(s):  
Hypericum Perforatum ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L

Effect of herbicides on St John's wort (Hypericum perforatum L.)

1991 ◽  
Vol 31 (4) ◽  
pp. 499 ◽  
Author(s):  
MH Campbell ◽  
BR Milne ◽  
JJ Dellow ◽  
HI Nicol
Keyword(s):  
Hypericum Perforatum ◽  
New South ◽  
Arable Land ◽  
Ground Cover ◽  
Aerial Application ◽  
St John’S Wort ◽  
Strong Trend ◽  
St John's Wort ◽  
South Wales ◽  
Hypericum Perforatum L

The effect of type of herbicide and time and rate of application on the reduction in ground cover of St John's wort (Hypericum perforatum L.) was determined at Orange, New South Wales. In January, April, July and November 1988, 8 herbicide treatments including the currently used glyphosate and picloram + 2,4-D were applied to vigorously growing H. perforaturn, and the reduction in percentage ground cover was recorded in December 1989. Ineffective herbicides (a.i./ha) were tebuthiuron, 0.8-6.4 kg; metsulfuron, 5-20 g; and paraquat + diquat, 0.4 + 0.5 kg. The addition of metsulfuron (2.5 g a.i./ha) to glyphosate (0.9 and 1.8 kg a.i./ha) did not increase the effectiveness of the latter. Effective herbicides (kg a.i./ha) were triclopyr + picloram, 0.6 + 0.2; picloram + 2,4-D, 0.2 + 0.8; glyphosate, 1.8; and triclopyr, 1.92. There was a strong trend for these herbicides to be more effective in January and November than in April and July. Based on price, effectiveness and selectivity, triclopyr + picloram would be preferred to the other herbicides for boom and spot spraying, and glyphosate would be the only herbicide suitable for aerial application prior to sowing improved pastures on non-arable land.

EXTRACTION OF HYPERFORIN AND HYPERICIN FROM ST. JOHN'S WORT (HYPERICUM PERFORATUM L.) WITH DIFFERENT SOLVENTS

2011 ◽  
Vol 35 (2) ◽  
pp. 222-235 ◽  
Author(s):  
DÁNIEL COSSUTA ◽  
TÜNDE VATAI ◽  
MÁRIA BÁTHORI ◽  
JUDIT HOHMANN ◽  
TIBOR KEVE ◽  
...  
Keyword(s):  
Hypericum Perforatum ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L

scholarly journals Extraction of resinoids from St. John's wort (Hypericum perforatum L): I. Efficiency and optimization of extraction

2002 ◽  
Vol 56 (2) ◽  
pp. 54-59 ◽  
Author(s):  
Dragan Milenovic ◽  
Vlada Veljkovic ◽  
Branimir Todorovic ◽  
Miomir Stankovic
Keyword(s):  
Plant Material ◽  
Hypericum Perforatum ◽  
Ethanol Solution ◽  
Operating Conditions ◽  
Solvent Ratio ◽  
Total Extract ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L ◽  
Full Factorial

The extraction of resinoids from St. John's wort (Hypericum perforatum L) was studied in a series of two papers. In the first part, the effects of the operating conditions on the yield of resinoids (total extract) were analyzed, while the mathematical models of extraction kinetics were compared in the second one. The extraction was carried out using an aqueous solution of ethanol (70 and 95 % v/v) at a hydromodulus (plant material to solvent ratio, w/v) of 1:5 or 1:10. The plant material was disintegrated and divided into three fractions (mean particle size: 0.23, 0.57 and 1.05 mm). The temperature was 25, 50 or about 80?C (boiling temperature). A higher yield of resinoids was obtained when the plant material of greater disintegration degree (0.23 mm) was treated with 70% v/v aqueous ethanol solution at higher hydromoduli (1:10) and temperatures (80?C). The effects of the operating factors on the yield of resinoids were estimated by using both the full factorial experimental plan 24 and artificial neuronic networks (ANN) of 3-4-1 topology. Of the two methods, the ANN one was found to be advantageous because of its capability of estimating the yield of resinoids in the whole range of the applied operating conditions.

Heavy Metal Contents of St. John’s wort (Hypericum perforatum L.) Growing in Northern Turkey

2006 ◽  
Vol 1 (3) ◽  
pp. 182-186 ◽  
Author(s):  
Ali Kemal Ayan ◽  
Ridvan Kizilkaya . ◽  
Cuneyt Cirak . ◽  
Kudret Kevseroglu .
Keyword(s):  
Heavy Metal ◽  
Hypericum Perforatum ◽  
St John’S Wort ◽  
St John's Wort ◽  
Metal Contents ◽  
Hypericum Perforatum L
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