Effect of percutaneous electrical stimulation of the spinal cord on the manifestation of reciprocal and presynaptic inhibition α-motor neurons of the lower leg muscles against the background of a weak isometric contraction in magnitude

The article presents the results of a study of the reflex mechanisms of reciprocal and presynaptic inhibition at rest and when performing an isometric reduction of 5% of MPS against the background of twenty-minute non-invasive electrical stimulation of the spinal cord. It was found that at rest against the background of electrical stimulation, reciprocal and presynaptic inhibition was inverted to their relief, and when performing plantar flexion of the foot, on the contrary, reciprocal and presynaptic inhibition increased, but the severity of presynaptic inhibition was greater. Key words: percutaneous electrical stimulation of the spinal cord, reciprocal inhibition, presynaptic inhibition, isometric contraction.

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Early postnatal development of GABAergic presynaptic inhibition of Ia proprioceptive afferent connections in mouse spinal cord

Journal of Neurophysiology ◽

10.1152/jn.00783.2012 ◽

2013 ◽

Vol 109 (8) ◽

pp. 2118-2128 ◽

Cited By ~ 9

Author(s):

Patrick M. Sonner ◽

David R. Ladle

Keyword(s):

Spinal Cord ◽

Postnatal Development ◽

Presynaptic Inhibition ◽

Dorsal Root ◽

Reciprocal Inhibition ◽

Afferent Feedback ◽

Early Postnatal Development ◽

Ia Afferent ◽

Ia Afferents ◽

Stimulation Of

Sensory feedback is critical for normal locomotion and adaptation to external perturbations during movement. Feedback provided by group Ia afferents influences motor output both directly through monosynaptic connections and indirectly through spinal interneuronal circuits. For example, the circuit responsible for reciprocal inhibition, which acts to prevent co-contraction of antagonist flexor and extensor muscles, is driven by Ia afferent feedback. Additionally, circuits mediating presynaptic inhibition can limit Ia afferent synaptic transmission onto central neuronal targets in a task-specific manner. These circuits can also be activated by stimulation of proprioceptive afferents. Rodent locomotion rapidly matures during postnatal development; therefore, we assayed the functional status of reciprocal and presynaptic inhibitory circuits of mice at birth and compared responses with observations made after 1 wk of postnatal development. Using extracellular physiological techniques from isolated and hemisected spinal cord preparations, we demonstrate that Ia afferent-evoked reciprocal inhibition is as effective at blocking antagonist motor neuron activation at birth as at 1 wk postnatally. In contrast, at birth conditioning stimulation of muscle nerve afferents failed to evoke presynaptic inhibition sufficient to block functional transmission at synapses between Ia afferents and motor neurons, even though dorsal root potentials could be evoked by stimulating the neighboring dorsal root. Presynaptic inhibition at this synapse was readily observed, however, at the end of the first postnatal week. These results indicate Ia afferent feedback from the periphery to central spinal circuits is only weakly gated at birth, which may provide enhanced sensitivity to peripheral feedback during early postnatal experiences.

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Effect of multisegmental electrical stimulation in combination with proprioceptive stimulation of the spinal cord on changes in reflex excitability of motor neurons

10.34014/mpphe.2021-249-251 ◽

2021 ◽

Author(s):

R.N. Yakupov ◽

S.S. Ananiev ◽

D.A. Pavlov ◽

I.V. Antipov ◽

M.V. Balykin

Keyword(s):

Neural Networks ◽

Spinal Cord ◽

Electrical Stimulation ◽

Motor Neurons ◽

Movement Disorders ◽

Reflex Excitability ◽

Central Origin ◽

Proprioceptive Stimulation ◽

Key Words Electrical Stimulation ◽

Stimulation Of

The study involved 15 men with movement disorders of central origin. We used percutaneous electrical stimulation of the spinal cord with the application of electrodes in the projection of the lumbar thickening, proprioceptive stimulation, and their combination. The data obtained showed the effectiveness of the combined course of percutaneous electrical stimulation of the spinal cord and proprioceptive stimulation on changes in the excitability of spinal locomotor neural networks. Key words: electrical stimulation, spinal cord, proprioceptive stimulation, rehabilitation, motor neuron.

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