BONE MINERAL DENSITY AND CONCENTRATION OF BETA CROSSLAPS IN PATIENTS WITH END-STAGE CHRONIC RENAL DISEASE

Background: Osteoporosis is a common complication in chronic kidney disease, with dangerous consequences such as fracture which make the disease more severe. For early detecting osteoporosis, it is important to measure bone mineral density and to assay bone turnover markers. The aims of this study were to determine the percentage of osteoporosis and osteopenia and to find an association between level of serum creatinine, level of beta-crosslaps and bone mineral density. Methods: A cross-sectional study. Measurement of BMD in patients with end-stage chronic renal disease in the department of nephrology and rheumatology, Hue central hospital from Oct 2010 to May 2011. Results: The prevalence of osteoporosis and osteopenia in end-stage chronic renal disease patients without hemodialysis is 47.37%. There is a significiantly relationship between concentration of serum creatinine, serum beta crosslaps and bone mineral density. Conclusion: The prevalence of osteoporosis and osteopenia in patients with end-stage chronic renal disease is high. There is a significantly relationship between level of serum beta-crosslaps, serum creatinine and bone mineral density. Keyword: bone mineral density, chronic kidney disease, bone turnover, osteoporosis, bone marker, beta-crosslaps.