Faculty Opinions recommendation of Impaired innate host defense causes susceptibility to respiratory virus infections in cystic fibrosis.

2003 ◽  
Author(s):  
Charles Bevins
Keyword(s):  
Cystic Fibrosis ◽  
Host Defense ◽  
Respiratory Virus ◽  
Virus Infections ◽  
Respiratory Virus Infections

scholarly journals Impaired Innate Host Defense Causes Susceptibility to Respiratory Virus Infections in Cystic Fibrosis

Immunity ◽  
2003 ◽  
Vol 18 (5) ◽  
pp. 619-630 ◽  
Author(s):  
Shuo Zheng ◽  
Bishnu P De ◽  
Suresh Choudhary ◽  
Suzy A.A Comhair ◽  
Tannishia Goggans ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Host Defense ◽  
Respiratory Virus ◽  
Virus Infections ◽  
Respiratory Virus Infections

scholarly journals Digging through the Obstruction: Insight into the Epithelial Cell Response to Respiratory Virus Infection in Patients with Cystic Fibrosis

2016 ◽  
Vol 90 (9) ◽  
pp. 4258-4261 ◽  
Author(s):  
Matthew R. Hendricks ◽  
Jennifer M. Bomberger
Keyword(s):  
Cystic Fibrosis ◽  
Lung Diseases ◽  
Respiratory Virus ◽  
Viral Infections ◽  
Molecular Diagnostic ◽  
Molecular Diagnostic Techniques ◽  
Virus Infections ◽  
Chronic Lung Diseases ◽  
Respiratory Viral Infections ◽  
Respiratory Virus Infections

Respiratory virus infections are common but generally self-limiting infections in healthy individuals. Although early clinical studies reported low detection rates, the development of molecular diagnostic techniques by PCR has led to an increased recognition that respiratory virus infections are associated with morbidity and acute exacerbations of chronic lung diseases, such as cystic fibrosis (CF). The airway epithelium is the first barrier encountered by respiratory viruses following inhalation and the primary site of respiratory viral replication. Here, we describe how the airway epithelial response to respiratory viral infections contributes to disease progression in patients with CF and other chronic lung diseases, including the role respiratory viral infections play in bacterial acquisition in the CF patient lung.

scholarly journals Home Self-Collection of Nasal Swabs for Diagnosis of Acute Respiratory Virus Infections in Children With Cystic Fibrosis

2013 ◽  
Vol 2 (4) ◽  
pp. 345-351 ◽  
Author(s):  
Julia Emerson ◽  
Elizabeth Cochrane ◽  
Sharon McNamara ◽  
Jane Kuypers ◽  
Ronald L. Gibson ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Respiratory Virus ◽  
Virus Infections ◽  
Nasal Swabs ◽  
Respiratory Virus Infections

Immunizations and vaccines: a decade of successes and reversals, and a call for ‘vaccine diplomacy’

2019 ◽  
Vol 11 (5) ◽  
pp. 331-333 ◽  
Author(s):  
Peter J Hotez
Keyword(s):  
Respiratory Virus ◽  
Neglected Tropical Diseases ◽  
Tropical Diseases ◽  
Virus Infections ◽  
Vaccination Programs ◽  
Vaccine Preventable Diseases ◽  
Health Gains ◽  
Potential Development ◽  
Respiratory Virus Infections ◽  
New Vaccines

Abstract Over the last decade we have seen extraordinary public health gains due to expansions in global vaccination programs led by United Nations (UN) agencies, including Gavi, the Vaccine Alliance, UNICEF and the WHO. These initiatives have reduced childhood deaths from measles, tetanus and other vaccine-preventable diseases by almost one half. There is additional excitement over the potential development and introduction of new vaccines to prevent highly lethal respiratory virus infections, as well as tuberculosis, malaria, HIV/AIDS and several neglected tropical diseases. However, these successes are under threat due to political instability, conflict and an accelerating antivaccine movement. New initiatives in vaccine diplomacy will be required to combat these challenges.

scholarly journals Histological evidence of pulmonary micro-thrombosis and vasculitis in life-threatening respiratory virus diseases

2020 ◽  
Author(s):  
Heather W Dolby ◽  
Philippe M D Potey ◽  
Annika Wilder-Smith ◽  
Sara Clohisey ◽  
Jonathan E Millar ◽  
...  
Keyword(s):  
Respiratory Virus ◽  
Virus Infections ◽  
Virus Diseases ◽  
Histological Evidence ◽  
Life Threatening ◽  
Respiratory Virus Infections

Abstract Pulmonary micro-thrombosis and vasculitis occur in fatal COVID-19. To determine if these processes occur in other life-threatening respiratory virus infections we identified autopsy studies of fatal influenza(n=455 patients), SARS(n=37), MERS(n=2), adenovirus(n=34) and RSV(n=30). Histological evidence of thrombosis was frequently present in adults with fatal influenza and SARS, with vasculitis also reported.

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