scholarly journals Elucidation of the Methylerythritol Phosphate Pathway for Isoprenoid Biosynthesis in Bacteria and Plastids. A Metabolic Milestone Achieved through Genomics

2002 ◽  
Vol 130 (3) ◽  
pp. 1079-1089 ◽  
Author(s):  
M. Rodriguez-Concepcion
Keyword(s):  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate

scholarly journals Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase

2005 ◽  
Vol 386 (1) ◽  
pp. 127-135 ◽  
Author(s):  
Lionel KUNTZ ◽  
Denis TRITSCH ◽  
Catherine GROSDEMANGE-BILLIARD ◽  
Andréa HEMMERLIN ◽  
Audrey WILLEM ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Malaria Parasite ◽  
Pathogenic Bacteria ◽  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum ◽  
Petri Dishes ◽  
Antiparasitic Drugs

Isoprenoid biosynthesis via the methylerythritol phosphate pathway is a target against pathogenic bacteria and the malaria parasite Plasmodium falciparum. 4-(Hydroxyamino)-4-oxobutylphosphonic acid and 4-[hydroxy(methyl)amino]-4-oxobutyl phosphonic acid, two novel inhibitors of DXR (1-deoxy-D-xylulose 5-phosphate reducto-isomerase), the second enzyme of the pathway, have been synthesized and compared with fosmidomycin, the best known inhibitor of this enzyme. The latter phosphonohydroxamic acid showed a high inhibitory activity towards DXR, much like fosmidomycin, as well as significant antibacterial activity against Escherichia coli in tests on Petri dishes.

scholarly journals Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis

2013 ◽  
Vol 82 (1) ◽  
pp. 497-530 ◽  
Author(s):  
Lishan Zhao ◽  
Wei-chen Chang ◽  
Youli Xiao ◽  
Hung-wen Liu ◽  
Pinghua Liu
Keyword(s):  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate

The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: Presence and sensitivity to fosmidomycin

2007 ◽  
Vol 116 (4) ◽  
pp. 375-384 ◽  
Author(s):  
Marc Clastre ◽  
Armelle Goubard ◽  
Anne Prel ◽  
Zoia Mincheva ◽  
Marie-Claude Viaud-Massuart ◽  
...  
Keyword(s):  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate

Isoprenoid biosynthesis via the methylerythritol phosphate pathway

2002 ◽  
Vol 269 (18) ◽  
pp. 4446-4457 ◽  
Author(s):  
Jean-François Hoeffler ◽  
Denis Tritsch ◽  
Catherine Grosdemange-Billiard ◽  
Michel Rohmer
Keyword(s):  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate

scholarly journals Mevalonate-independent methylerythritol phosphate pathway for isoprenoid biosynthesis. Elucidation and distribution

2003 ◽  
Vol 75 (2-3) ◽  
pp. 375-388 ◽  
Author(s):  
M. Rohmer
Keyword(s):  
Metabolic Pathway ◽  
Biosynthetic Pathway ◽  
Mevalonate Pathway ◽  
State Of The Art ◽  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate ◽  
Antiparasitic Drugs ◽  
Novel Target ◽  
Key Steps

A long-overlooked metabolic pathway for isoprenoid biosynthesis, the mevalonate-independent methylerythritol phosphate (MEP) pathway, is present in many bacteria and in the chloroplasts of all phototrophic organisms. It represents an alternative to the well known mevalonate pathway, which is present in animals, fungi, plant cytoplasm, archaebacteria, and some eubacteria. This contribution summarizes key steps of its elucidation and the state-of-the-art knowledge of this biosynthetic pathway, which represents a novel target for antibacterial and antiparasitic drugs.

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