Cloning and functional characterization of an enzyme from Helicobacter pylori that catalyzes two steps of the methylerythritol phosphate pathway for isoprenoid biosynthesis

2010 ◽  
Vol 1800 (9) ◽  
pp. 919-928 ◽  
Author(s):  
Jordi Pérez-Gil ◽  
María Bergua ◽  
Albert Boronat ◽  
Santiago Imperial
Keyword(s):  
Helicobacter Pylori ◽  
Functional Characterization ◽  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate

Functional characterization of the antagonistic flagellar late regulators FliA and FlgM of Helicobacter pylori and their effects on the H. pylori transcriptome

2002 ◽  
Vol 43 (2) ◽  
pp. 307-322 ◽  
Author(s):  
Christine Josenhans ◽  
Eike Niehus ◽  
Stefanie Amersbach ◽  
Andrea Hörster ◽  
Christian Betz ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Functional Characterization ◽  
H Pylori

scholarly journals Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase

2005 ◽  
Vol 386 (1) ◽  
pp. 127-135 ◽  
Author(s):  
Lionel KUNTZ ◽  
Denis TRITSCH ◽  
Catherine GROSDEMANGE-BILLIARD ◽  
Andréa HEMMERLIN ◽  
Audrey WILLEM ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Malaria Parasite ◽  
Pathogenic Bacteria ◽  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate ◽  
Parasite Plasmodium ◽  
Parasite Plasmodium Falciparum ◽  
Petri Dishes ◽  
Antiparasitic Drugs

Isoprenoid biosynthesis via the methylerythritol phosphate pathway is a target against pathogenic bacteria and the malaria parasite Plasmodium falciparum. 4-(Hydroxyamino)-4-oxobutylphosphonic acid and 4-[hydroxy(methyl)amino]-4-oxobutyl phosphonic acid, two novel inhibitors of DXR (1-deoxy-D-xylulose 5-phosphate reducto-isomerase), the second enzyme of the pathway, have been synthesized and compared with fosmidomycin, the best known inhibitor of this enzyme. The latter phosphonohydroxamic acid showed a high inhibitory activity towards DXR, much like fosmidomycin, as well as significant antibacterial activity against Escherichia coli in tests on Petri dishes.

scholarly journals Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis

2013 ◽  
Vol 82 (1) ◽  
pp. 497-530 ◽  
Author(s):  
Lishan Zhao ◽  
Wei-chen Chang ◽  
Youli Xiao ◽  
Hung-wen Liu ◽  
Pinghua Liu
Keyword(s):  
Isoprenoid Biosynthesis ◽  
Methylerythritol Phosphate Pathway ◽  
Methylerythritol Phosphate
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