Faculty Opinions recommendation of Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons.

2004 ◽  
Author(s):  
Marina Picciotto
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Mammalian Cells ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine ◽  
Midbrain Neurons

scholarly journals The Oncogenic Functions of Nicotinic Acetylcholine Receptors

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Yue Zhao
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Mammalian Cells ◽  
Acetylcholine Receptors ◽  
Association Studies ◽  
Nicotine Addiction ◽  
Signal Pathways ◽  
Genome Wide Association Studies ◽  
Nicotinic Acetylcholine ◽  
Lung Cancers ◽  
Numerous Cell

Nicotinic acetylcholine receptors (nAChRs) are ion channels that are expressed in the cell membrane of all mammalian cells, including cancer cells. Recent findings suggest that nAChRs not only mediate nicotine addiction in the brain but also contribute to the development and progression of cancers directly induced by nicotine and its derived carcinogenic nitrosamines whereas deregulation of the nAChRs is observed in many cancers, and genome-wide association studies (GWAS) indicate that SNPs nAChRs associate with risks of lung cancers and nicotine addiction. Emerging evidences suggest nAChRs are posited at the central regulatory loops of numerous cell growth and prosurvival signal pathways and also mediate the synthesis and release of stimulatory and inhibitory neurotransmitters induced by their agonists. Thus nAChRs mediated cell signaling plays an important role in stimulating the growth and angiogenic and neurogenic factors and mediating oncogenic signal transduction during cancer development in a cell type specific manner. In this review, we provide an integrated view of nAChRs signaling in cancer, heightening on the oncogenic properties of nAChRs that may be targeted for cancer treatment.

scholarly journals Counting Bungarotoxin Binding Sites of Nicotinic Acetylcholine Receptors in Mammalian Cells with High Signal/Noise Ratios

2010 ◽  
Vol 99 (10) ◽  
pp. L81-L83 ◽  
Author(s):  
Paul D. Simonson ◽  
Hannah A. DeBerg ◽  
Pinghua Ge ◽  
John K. Alexander ◽  
Okunola Jeyifous ◽  
...  
Keyword(s):  
Nicotinic Acetylcholine Receptors ◽  
Binding Sites ◽  
Mammalian Cells ◽  
Acetylcholine Receptors ◽  
High Signal ◽  
Nicotinic Acetylcholine ◽  
Signal Noise

scholarly journals Single-Molecule Imaging of AMPA and Nicotinic Acetylcholine Receptors in Mammalian Cells

2009 ◽  
Vol 96 (3) ◽  
pp. 29a
Author(s):  
Paul D. Simonson ◽  
John Alexander ◽  
Okunola Jeyifous ◽  
William N. Green ◽  
Paul R. Selvin
Keyword(s):  
Single Molecule ◽  
Nicotinic Acetylcholine Receptors ◽  
Mammalian Cells ◽  
Acetylcholine Receptors ◽  
Single Molecule Imaging ◽  
Nicotinic Acetylcholine

Nicotinic acetylcholine receptors in the patients with Parkinson's disease: 5IA-SPECT

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S586-S586 ◽  
Author(s):  
Kazuo Hashikawa ◽  
Hidefumi Yoshida ◽  
Nobukatsu Sawamoto ◽  
Shigetoshi Takaya ◽  
Chihiro Namiki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine
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