Faculty Opinions recommendation of Proximodistal patterning during limb regeneration.

2005 ◽  
Author(s):  
Jonathan Slack
Keyword(s):  
Limb Regeneration

scholarly journals Diabetes mellitus impairs limb regeneration as analyzed in adult zebrafish

2010 ◽  
Vol 344 (1) ◽  
pp. 518
Author(s):  
Michael P. Sarras ◽  
Ansgar Olsen ◽  
Robert Intine
Keyword(s):  
Diabetes Mellitus ◽  
Limb Regeneration ◽  
Adult Zebrafish

Cell cycle controls and the role of nerves and the regenerate epithelium in urodele forelimb regeneration: possible modifications of basic concepts

1987 ◽  
Vol 65 (8) ◽  
pp. 739-749 ◽  
Author(s):  
Roy A. Tassava ◽  
David J. Goldhamer ◽  
Bruce L. Tomlinson
Keyword(s):  
Cell Cycle ◽  
Monoclonal Antibody ◽  
Limb Regeneration ◽  
Blastema Formation ◽  
Basic Concepts ◽  
Regenerate Epithelium ◽  
Early Wound ◽  
Skin Epidermis ◽  
Wound Epithelium

Data from pulse and continuous labeling with [3H]thymidine and from studies with monoclonal antibody WE3 have led to the modification of existing models and established concepts pertinent to understanding limb regeneration. Not all cells of the adult newt blastema are randomly distributed and actively progressing through the cell cycle. Instead, many cells are in a position that we have designated transient quiescence (TQ) and are not actively cycling. We postulate that cells regularly leave the TQ population and enter the actively cycling population and vice versa. The size of the TQ population may be at least partly determined by the quantity of limb innervation. Larval Ambystoma may have only a small or nonexisting TQ, thus accounting for their rapid rate of regeneration. Examination of reactivity of monoclonal antibody WE3 suggests that the early wound epithelium, which is derived from skin epidermis, is later replaced by cells from skin glands concomitant with blastema formation. WE3 provides a useful tool to further investigate the regenerate epithelium.

The role of larval skin in promoting limb regeneration in adult Anura

1944 ◽  
Vol 97 (1) ◽  
pp. 71-93 ◽  
Author(s):  
Natalie M. Gidge ◽  
S. Meryl Rose
Keyword(s):  
Limb Regeneration

scholarly journals Normal newt limb regeneration requires matrix metalloproteinase function

2005 ◽  
Vol 279 (1) ◽  
pp. 86-98 ◽  
Author(s):  
Vladimir Vinarsky ◽  
Donald L. Atkinson ◽  
Tamara J. Stevenson ◽  
Mark T. Keating ◽  
Shannon J. Odelberg
Keyword(s):  
Matrix Metalloproteinase ◽  
Limb Regeneration ◽  
Newt Limb

scholarly journals Microarray Analysis of microRNA Expression during Axolotl Limb Regeneration

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e41804 ◽  
Author(s):  
Edna C. Holman ◽  
Leah J. Campbell ◽  
John Hines ◽  
Craig M. Crews
Keyword(s):  
Microarray Analysis ◽  
Limb Regeneration ◽  
Microrna Expression

scholarly journals The Role of the Prod1 Membrane Anchor in Newt Limb Regeneration

2016 ◽  
Vol 129 (1) ◽  
pp. 276-280
Author(s):  
Kaoru Nomura ◽  
Yasushi Tanimoto ◽  
Fumio Hayashi ◽  
Erisa Harada ◽  
Xiao-Yuan Shan ◽  
...  
Keyword(s):  
Limb Regeneration ◽  
Membrane Anchor ◽  
Newt Limb

Citral, an inhibitor of retinoic acid synthesis, modifies pattern formation during limb regeneration in the axolotl Ambystoma mexicanum

1999 ◽  
Vol 77 (11) ◽  
pp. 1835-1837 ◽  
Author(s):  
Steven R Scadding
Keyword(s):  
Retinoic Acid ◽  
Pattern Formation ◽  
Limb Regeneration ◽  
Acid Synthesis ◽  
Ambystoma Mexicanum

While the effects of exogenous retinoids on amphibian limb regeneration have been studied extensively, the role of endogenous retinoids is not clear. Hence, I wished to investigate the role of endogenous retinoic acid during axolotl limb regeneration. Citral is a known inhibitor of retinoic acid synthesis. Thus, I treated regenerating limbs of the larval axolotl Ambystoma mexicanum with citral. The result of this inhibition of retinoic acid synthesis was that limb regeneration became extremely irregular and hypomorphic, with serious pattern defects, or was inhibited altogether. I conclude that endogenous retinoic acid plays an important role in pattern formation during limb regeneration.

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