Faculty Opinions recommendation of Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand.

2007 ◽  
Author(s):  
Rachel R Caspi
Keyword(s):  
Dendritic Cells ◽  
T Regulatory Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Regulatory Cells ◽  
Inducible Costimulator

scholarly journals Bifidobacterium infantis35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells

Gut ◽  
2011 ◽  
Vol 61 (3) ◽  
pp. 354-366 ◽  
Author(s):  
Patrycja Konieczna ◽  
David Groeger ◽  
Mario Ziegler ◽  
Remo Frei ◽  
Ruth Ferstl ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Peripheral Blood ◽  
Potential Role ◽  
T Regulatory Cells ◽  
Human Peripheral Blood ◽  
Plasmacytoid Dendritic Cells ◽  
Regulatory Cells

scholarly journals Plasmacytoid Dendritic Cells: From Heart to Vessels

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Rosalinda Sorrentino ◽  
Silvana Morello ◽  
Aldo Pinto
Keyword(s):  
Dendritic Cells ◽  
Cardiovascular Diseases ◽  
T Regulatory Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Type I ◽  
Regulatory Cells ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Stromal Component ◽  
Proinflammatory Responses

Cardiovascular diseases, formerly only attributed to the alterations of the stromal component, are now recognized as immune-based pathologies. Plasmacytoid Dendritic Cells (pDCs) are important immune orchestrators in heart and vessels. They highly produce IFN type I that promote the polarization of T cells towards a Th1 phenotype; however, pDCs can also participate to suppressive networks via the recruitment of T regulatory cells that downmodulate proinflammatory responses. pDCs populate the vessel wall layers during pathological conditions, such as atherosclerosis. It is thus clear that a better identification of pDCs activity in cardiovascular diseases can not only elucidate pathological mechanisms but also lead to new therapeutic approaches.

High PD-L1/CD86 Ratio on Plasmacytoid Dendritic Cells Correlates With Elevated T-Regulatory Cells in Liver Transplant Tolerance

2008 ◽  
Vol 85 (3) ◽  
pp. 369-377 ◽  
Author(s):  
Daisuke Tokita ◽  
George V. Mazariegos ◽  
Alan F. Zahorchak ◽  
Nydia Chien ◽  
Masanori Abe ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Liver Transplant ◽  
T Regulatory Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Regulatory Cells ◽  
Transplant Tolerance

scholarly journals Plasmacytoid Dendritic Cells Promote Immunosuppression in Ovarian Cancer via ICOS Costimulation of Foxp3+ T-Regulatory Cells

2012 ◽  
Vol 72 (20) ◽  
pp. 5240-5249 ◽  
Author(s):  
Curdin Conrad ◽  
Josh Gregorio ◽  
Yi-Hong Wang ◽  
Tomoki Ito ◽  
Stephan Meller ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Dendritic Cells ◽  
T Regulatory Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Regulatory Cells

scholarly journals Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand

2007 ◽  
Vol 204 (1) ◽  
pp. 105-115 ◽  
Author(s):  
Tomoki Ito ◽  
Maria Yang ◽  
Yui-Hsi Wang ◽  
Roberto Lande ◽  
Josh Gregorio ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
T Regulatory Cells ◽  
Interleukin 10 ◽  
Regulatory Cells ◽  
Myeloid Dendritic Cells ◽  
Cell Responses ◽  
Inducible Costimulator ◽  
Th2 Differentiation

Although there is evidence for distinct roles of myeloid dendritic cells (DCs [mDCs]) and plasmacytoid pre-DCs (pDCs) in regulating T cell–mediated adaptive immunity, the concept of functional DC subsets has been questioned because of the lack of a molecular mechanism to explain these differences. In this study, we provide direct evidence that maturing mDCs and pDCs express different sets of molecules for T cell priming. Although both maturing mDCs and pDCs upregulate the expression of CD80 and CD86, only pDCs upregulate the expression of inducible costimulator ligand (ICOS-L) and maintain high expression levels upon differentiation into mature DCs. High ICOS-L expression endows maturing pDCs with the ability to induce the differentiation of naive CD4 T cells to produce interleukin-10 (IL-10) but not the T helper (Th)2 cytokines IL-4, -5, and -13. These IL-10–producing T cells are T regulatory cells, and their generation by ICOS-L is independent of pDC-driven Th1 and Th2 differentiation, although, in the later condition, some contribution from endogenous IL-4 cannot be completely ruled out. Thus, in contrast to mDCs, pDCs are poised to express ICOS-L upon maturation, which leads to the generation of IL-10–producing T regulatory cells. Our findings demonstrate that mDC and pDCs are intrinsically different in the expression of costimulatory molecules that drive distinct types of T cell responses.

Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4+ T helper cells and CD4+ CD25hi T regulatory cells

2005 ◽  
Vol 35 (8) ◽  
pp. 2452-2458 ◽  
Author(s):  
Chiara Romagnani ◽  
Mariella Della Chiesa ◽  
Siegfried Kohler ◽  
Beate Moewes ◽  
Andreas Radbruch ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Nk Cells ◽  
T Helper Cells ◽  
T Regulatory Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Regulatory Cells ◽  
T Helper ◽  
Helper Cells

Defective levels of both circulating dendritic cells and T-regulatory cells correlate with risk of recurrence in cutaneous melanoma

2018 ◽  
Vol 21 (7) ◽  
pp. 845-854 ◽  
Author(s):  
M. Tucci ◽  
L. S. Stucci ◽  
F. Mannavola ◽  
A. Passarelli ◽  
S. D’Oronzo ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Cutaneous Melanoma ◽  
T Regulatory Cells ◽  
Regulatory Cells ◽  
Risk Of Recurrence
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