Faculty Opinions recommendation of Effect of short-term NSAID use on echocardiographic parameters in elderly people: a population-based cohort study.

Author(s):  
Melvin Cheitlin
Heart ◽  
2010 ◽  
Vol 97 (7) ◽  
pp. 540-543 ◽  
Author(s):  
K. E. van den Hondel ◽  
M. Eijgelsheim ◽  
R. Ruiter ◽  
J. C. M. Witteman ◽  
A. Hofman ◽  
...  

2021 ◽  
Vol 79 ◽  
pp. S250-S251
Author(s):  
K-J. Lundström ◽  
H. Garmo ◽  
R. Gedeborg ◽  
P. Stattin ◽  
J. Styrke

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S65-S66 ◽  
Author(s):  
Wing Chung Chang ◽  
Joe Kwun Nam Chan ◽  
Corine Sau Man Wong ◽  
Philip Chi Fai Or ◽  
JoJo Siu Han Hai

Abstract Background Ischemic heart disease is the leading cause of premature mortality in psychotic disorders. The authors aimed to examine short-term mortality, cardiovascular complications, revascularization and cardioprotective medication receipt after incident acute coronary syndrome (ACS) among patients with psychotic disorders compared with patients without psychotic disorders. Methods This was a population-based cohort study with data retrieved from a territory-wide medical record database of public healthcare services to 7.5 million residents in Hong Kong. The study identified 67,692 patients aged ≥18 years admitted for first-recorded ACS between January 1, 2006 and December 31, 2016. The cohort was dichotomously divided by pre-ACS diagnosis of psychotic disorder. Multivariate regression (adjusted odds ratio [aOR] and 95%CI) was used to examine associations of psychotic disorders with all-cause 30-day and 1-year mortality, cardiovascular complications, 30-day and 1-year invasive cardiac procedures, and 90-day post-discharge cardioprotective medication prescription. Results Patients with psychotic disorders (N=703) had higher 30-day (aOR=1.99, 95%CI=1.65–2.39) and 1-year (aOR=2.13, 95%CI=1.79–2.54) mortality, and cardiovascular complication rates (aOR=1.20, 95%CI=1.02–1.41), lower receipt of cardiac catheterization (30-day: aOR=0.54, 95%CI=0.43–0.68; 1-year: aOR=0.46, 95%CI=0.38–0.56), percutaneous coronary intervention (30-day: aOR=0.55, 95%CI=0.44–0.70; 1-year: aOR=0.52, 95%CI=0.42–0.63) and reduced β-blockers (aOR=0.81, 95%CI=0.68–0.97), statins (aOR=0.54, 95%CI=0.44–0.66), and clopidogrel prescriptions (aOR=0.66, 95%CI=0.55–0.80). Effect of psychotic disorder on heightened mortality was more pronounced in younger-aged (<65 years) and male patients. Associations between psychotic disorder and increased mortality remained significant even after complications and treatment receipt were additionally adjusted. Discussion Psychotic disorders are associated with increased risks of short-term post-ACS mortality, cardiovascular complications and inferior treatment. Excess mortality is not substantially explained by treatment inequality. Further investigation is warranted to clarify factors for suboptimal cardiac-care and elevated mortality in psychotic disorders to enhance post-ACS outcome.


Author(s):  
Stine Ibsen ◽  
Tim Alex Lindskou ◽  
Christian H. Nickel ◽  
Torben Kløjgård ◽  
Erika Frischknecht Christensen ◽  
...  

Abstract Background Emergency medical service patients are a vulnerable population and the risk of mortality is considerable. In Denmark, healthcare professionals receive 112-emergency calls and assess the main reason for calling. The main aim was to investigate which of these reasons, i.e. which symptoms or mechanism of injury, contributed to short-term risk of death. Secondary aim was to study 1–30 day-mortality for each symptom/ injury. Methods Historic population-based cohort study of emergency medical service patients calling 112 in the North Denmark Region between 01.01.2016–31.12.2018. We defined 1-day mortality as death on the same or the following day. The frequency of each symptom and cumulative number of deaths on day 1 and 30 together with 1- and 30-day mortality for each symptom/mechanism of injury is presented in proportions. Poisson regression with robust variance estimation was used to estimate incident rates (IR) of mortality with 95% confidence intervals (CI), crude and age and sex adjusted, mortality rates on day 1 per 100,000 person-year in the population. Results The five most frequent reasons for calling 112 were “chest pain” (15.9%), “unclear problem” (11.9%), “accidents” (11.2%), “possible stroke” (10.9%), and “breathing difficulties” (8.3%). Four of these contributed to the highest numbers of deaths: “breathing difficulties” (17.2%), “unclear problem” (13.2%), “possible stroke” (8.7%), and “chest pain” (4.7%), all exceeded by “unconscious adult – possible cardiac arrest” (25.3%). Age and sex adjusted IR of mortality per 100,000 person-year was 3.65 (CI 3.01–4.44) for “unconscious adult – possible cardiac arrest” followed by “breathing difficulties” (0.45, CI 0.37–0.54), “unclear problem”(0.30, CI 0.11–0.17), “possible stroke”(0.13, CI 0.11–0.17) and “chest pain”(0.07, CI 0.05–0.09). Conclusion In terms of risk of death on the same day and the day after the 112-call, “unconscious adult/possible cardiac arrest” was the most deadly symptom, about eight times more deadly than “breathing difficulties”, 12 times more deadly than “unclear problem”, 28 times more deadly than “possible stroke”, and 52 times more deadly than “chest pain”. “Breathing difficulties” and “unclear problem” as presented when calling 112 are among the top three contributing to short term deaths when calling 112, exceeding both stroke symptoms and chest pain.


2008 ◽  
Vol 28 (7) ◽  
pp. 895-902 ◽  
Author(s):  
C. CHRISTIANSEN ◽  
S. CHRISTENSEN ◽  
A. RIIS ◽  
R. W. THOMSEN ◽  
S. P. JOHNSEN ◽  
...  

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