Faculty Opinions recommendation of Transforming growth factor-β/Smad - signalling pathway and conjunctival remodelling in vernal keratoconjunctivitis.

2011 ◽  
Author(s):  
Elizabeth Kelly ◽  
Jim Stahl
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway ◽  
Vernal Keratoconjunctivitis

scholarly journals Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-β signalling

2011 ◽  
Vol 7 (5) ◽  
pp. 759-762 ◽  
Author(s):  
Yoshihisa Kurita ◽  
Hiroshi Wada
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Driving Force ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway ◽  
Retractor Muscle ◽  
Cast Doubt ◽  
The Right ◽  
Ontogenetic Process

Gastropods are characterized by their asymmetric bodyplan, which develops through a unique ontogenetic process called ‘torsion’. Despite several intensive studies, the driving force of torsion remains to be determined. Although torsion was traditionally believed to be driven by contraction of the retractor muscle connecting the foot and the shell, some recent reports cast doubt on that idea. Here, we report that torsion is accompanied by left–right asymmetric cell proliferation in the mantle epithelium in the limpet Nipponacmea fuscoviridis . Furthermore, we found that pharmacological inhibition of the transforming growth factor-β (TGF-β) signalling pathway, including that of Nodal, blocked torsion. We confirmed that the blocking was brought about through failure of the activation of cell proliferation in the right-hand side of the mantle epithelium, while the retractor muscle apparently developed normally. These results suggest that limpet torsion is driven by left–right asymmetric cell proliferation in the mantle epithelium, induced by the TGF-β pathway.

scholarly journals Inhibition of CD1d-mediated antigen presentation by the transforming growth factor-β/Smad signalling pathway

Immunology ◽  
2014 ◽  
Vol 143 (4) ◽  
pp. 679-691 ◽  
Author(s):  
Jennifer C. Bailey ◽  
Abhirami K. Iyer ◽  
Gourapura J. Renukaradhya ◽  
Yinling Lin ◽  
Hoa Nguyen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Antigen Presentation ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway

scholarly journals Expression and clinical significance of the transforming growth factor-β signalling pathway in endometrial cancer

2011 ◽  
Vol 59 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Paulette Mhawech-Fauceglia ◽  
Joshua Kesterson ◽  
Dan Wang ◽  
Stacey Akers ◽  
Nefertiti Chianti DuPont ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Growth Factor ◽  
Clinical Significance ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway

scholarly journals Transforming growth factor beta signaling in hepatocellular carcinoma: as a victim or culprit?

2019 ◽  
Vol 6 (3) ◽  
pp. 991
Author(s):  
Varun Kumar Sharma ◽  
Charu Tyagi ◽  
Yugandhar P. Reddy ◽  
Jayanand Manjhi ◽  
Lomas Kumar Tomar
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway ◽  
Expression Of Genes ◽  
Tgfβ Signalling ◽  
Growth Factor Beta ◽  
Tgfβ Pathway

The transforming growth factor-β (TGFβ) signalling pathway control various cellular function and play a pivotal role in tumour suppression. In contrary, overexpression of TGFβ is linked to promote the cancer development. TGFβ facilitate cell-growth and cell-differentiation process which support tumour propagation. In case of hepatocellular carcinoma (HCC), TGFβ signalling pathway is the master regulator of HCCs pathogenesis and functionally involved in the regulation of HCCs phenotype via modulating the downstream signalling pathways. In this article, we have highlighted the contradictory behaviour of TGFβ in hepatocellular carcinoma. Observations suggest that the TGFβ signalling pathway is positively correlated to the expression of genes linked with various hepatic pathological conditions, including fibrosis, cirrhosis, inflammation and cancer. TGFβ pathway play dual role as pro and anti-tumoural activities in cancer cells depending on their context.

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