Faculty Opinions recommendation of Do red blood cell-beta-amyloid interactions alter oxygen delivery in Alzheimer's disease?

Author(s):  
George Perry
Author(s):  
C. Hooper ◽  
P. De Souto Barreto ◽  
M. Pahor ◽  
M. Weiner ◽  
B. Vellas

Significant research attention has focussed on the identification of nutraceutical agents for the prevention of cognitive decline as a natural means of cognitive preservation in the elderly. There is some evidence for a reduction of brain omega 3 polyunsaturated fatty acids (n-3 PUFAs) in normal aging and in Alzheimer’s disease. n-3 PUFAs exhibit anti-inflammatory and anti-amyloidogenic properties as well as being able to reduce tau phosphorylation. Many observational studies have demonstrated a link between n-3 PUFAs and cognitive aging, and some, but not all, randomized controlled trials have demonstrated a benefit of n-3 PUFA supplementation on cognition, particularly in those subjects with mild cognitive impairment. The identification of a biomarker that reflects n-3 PUFA intake over time and consequent tissue levels is required. In this narrative review we discuss the evidence associating red blood cell membrane n-3 PUFAs with cognitive function and structural brain changes associated with Alzheimer’s disease. Key words: Docosahexaenoic acid, omega 3 polyunsaturated fatty aci


2007 ◽  
Vol 50 (2) ◽  
pp. 308-313 ◽  
Author(s):  
Zsuzsanna Hartai ◽  
Anna Juhász ◽  
Ágnes Rimanóczy ◽  
Tamás Janáky ◽  
Teodóra Donkó ◽  
...  

1985 ◽  
Vol 20 (4) ◽  
pp. 367-374 ◽  
Author(s):  
Blaine S. Greenwald ◽  
James Edasery ◽  
Richard C. Mohs ◽  
Naren Shah ◽  
Gaston Germain Trigos ◽  
...  

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Eleonora Del Prete ◽  
Simona Daniele ◽  
Linda Giampietri ◽  
Alessandro Galgani ◽  
Rebecca Piccarducci ◽  
...  

1985 ◽  
Vol 20 (4) ◽  
pp. 375-383 ◽  
Author(s):  
Philip D. Kanof ◽  
Blaine S. Greenwald ◽  
Richard C. Mohs ◽  
Kenneth L. Davis

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