Faculty Opinions recommendation of MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation.

2009 ◽  
Author(s):  
Nicola Gray ◽  
Matt Brook
Keyword(s):  
Stem Cell ◽  
Rna Binding ◽  
Germ Line ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Self Renewal ◽  
Germ Line Stem Cell

scholarly journals MILI, a PIWI-interacting RNA-binding Protein, Is Required for Germ Line Stem Cell Self-renewal and Appears to Positively Regulate Translation

2008 ◽  
Vol 284 (10) ◽  
pp. 6507-6519 ◽  
Author(s):  
Yingdee Unhavaithaya ◽  
Yi Hao ◽  
Ergin Beyret ◽  
Hang Yin ◽  
Satomi Kuramochi-Miyagawa ◽  
...  
Keyword(s):  
Stem Cell ◽  
Rna Binding ◽  
Germ Line ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Self Renewal ◽  
Germ Line Stem Cell

scholarly journals LST-1 acts in trans with a conserved RNA-binding protein to maintain stem cells

2019 ◽  
Author(s):  
Kimberly A. Haupt ◽  
Amy L. Enright ◽  
Ahlan S. Ferdous ◽  
Aaron M. Kershner ◽  
Heaji Shin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Regulatory Region ◽  
Rna Binding Protein ◽  
Point Mutations ◽  
Distinct Region ◽  
Protein Distribution ◽  
Self Renewal ◽  
C Elegans

ABSTRACTStem cell self-renewal is essential to development and tissue repair. The C. elegans LST-1 protein is a pivotal regulator of self-renewal and oncogenic when misexpessed. Here we define regions within the LST-1 protein that provide molecular insights into both its function and regulation. LST-1 self-renewal activity resides within a predicted disordered region that harbors two KXXL motifs. These KXXL motifs mediate LST-1 binding to FBF, a broadly conserved Pumilio/PUF RNA-binding protein that represses differentiation. Point mutations of the KXXL motifs abrogate LST-1 self-renewal activity. Therefore, FBF binding is essential to LST-1 function. A second distinct region regulates LST-1 spatial expression and primarily affects LST-1 protein turnover. Upon loss of this regulatory region, LST-1 protein distribution expands and drives formation of a larger than normal GSC pool. Thus, LST-1 promotes self-renewal as a key FBF partner, and its spatial regulation helps determine size of the GSC pool.IMPACT STATEMENTA key stem cell regulator partners with a broadly conserved PUF RNA-binding protein to drive self-renewal and maintain a stem cell pool.

scholarly journals The RNA‐binding protein Imp2 regulates oxidative phosporylation that is key to glioblastoma cancer stem cell maintenance

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Michalina Janiszewska ◽  
Mario-Luca Suva ◽  
Riekelt H. Houtkooper ◽  
Virginie Clement-Schatlo ◽  
Ivan Stamenkovic
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Stem Cell Maintenance ◽  
Cell Maintenance

scholarly journals RNA binding protein RBM3 promotes a cancer stem cell phenotype with multidrug resistance

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Anand Venugopal ◽  
Deep Kwatra ◽  
Shane Stecklein ◽  
Satish Ramalingam ◽  
Dharmalingam Subramaniam ◽  
...  
Keyword(s):  
Stem Cell ◽  
Multidrug Resistance ◽  
Cancer Stem Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cell Phenotype ◽  
Cancer Stem Cell Phenotype ◽  
Stem Cell Phenotype

scholarly journals Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs

2020 ◽  
Vol 117 (7) ◽  
pp. 3603-3609 ◽  
Author(s):  
Fan Zou ◽  
Renjun Tu ◽  
Bo Duan ◽  
Zhenlin Yang ◽  
Zhaohua Ping ◽  
...  
Keyword(s):  
Stem Cell ◽  
Rna Binding ◽  
Germ Line ◽  
Adult Stem Cell ◽  
Cell Development ◽  
Rna Modification ◽  
Proliferation And Differentiation ◽  
Germ Line Stem Cell ◽  
Rna Complex

5-Methylcytosine (m5C) is a RNA modification that exists in tRNAs and rRNAs and was recently found in mRNAs. Although it has been suggested to regulate diverse biological functions, whether m5C RNA modification influences adult stem cell development remains undetermined. In this study, we show that Ypsilon schachtel (YPS), a homolog of human Y box binding protein 1 (YBX1), promotes germ line stem cell (GSC) maintenance, proliferation, and differentiation in the Drosophila ovary by preferentially binding to m5C-containing RNAs. YPS is genetically demonstrated to function intrinsically for GSC maintenance, proliferation, and progeny differentiation in the Drosophila ovary, and human YBX1 can functionally replace YPS to support normal GSC development. Highly conserved cold-shock domains (CSDs) of YPS and YBX1 preferentially bind to m5C RNA in vitro. Moreover, YPS also preferentially binds to m5C-containing RNAs, including mRNAs, in germ cells. The crystal structure of the YBX1 CSD-RNA complex reveals that both hydrophobic stacking and hydrogen bonds are critical for m5C binding. Overexpression of RNA-binding–defective YPS and YBX1 proteins disrupts GSC development. Taken together, our findings show that m5C RNA modification plays an important role in adult stem cell development.

scholarly journals The RNA-Binding Protein RBM3 Promotes Neural Stem Cell (NSC) Proliferation Under Hypoxia

2019 ◽  
Vol 7 ◽  
Author(s):  
Jingyi Yan ◽  
Tessa Goerne ◽  
Andrea Zelmer ◽  
Raphael Guzman ◽  
Josef P. Kapfhammer ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

scholarly journals The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity

2006 ◽  
Vol 103 (22) ◽  
pp. 8402-8407 ◽  
Author(s):  
N. A. Siddall ◽  
E. A. McLaughlin ◽  
N. L. Marriner ◽  
G. R. Hime
Keyword(s):  
Stem Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cell Identity

scholarly journals Mouse-Musashi-1, a Neural RNA-Binding Protein Highly Enriched in the Mammalian CNS Stem Cell

1996 ◽  
Vol 176 (2) ◽  
pp. 230-242 ◽  
Author(s):  
Shin-ichi Sakakibara ◽  
Takao Imai ◽  
Kayoko Hamaguchi ◽  
Masataka Okabe ◽  
Jun Aruga ◽  
...  
Keyword(s):  
Stem Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Mammalian Cns
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