Faculty Opinions recommendation of A randomized controlled trial of treatment options for troublesome uterine bleeding in Implanon users.

Background: Subacromial impingement syndrome (SAIS) is the most common disorder of the shoulder. The evidence for the effectiveness of treatment options is inconclusive and limited. Therefore, there is a need for more evidence in this regard, particularly for long-term outcomes. Hypothesis: Platelet-rich plasma (PRP) would be an effective method in treating subacromial impingement. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This was a single-blinded randomized clinical trial with 1-, 3-, and 6-month follow-up. Sixty-two patients were randomly placed into 2 groups, receiving either PRP or exercise therapy. The outcome parameters were pain, shoulder range of motion (ROM), muscle force, functionality, and magnetic resonance imaging findings. Results: Both treatment options significantly reduced pain and increased shoulder ROM compared with baseline measurements. Both treatments also significantly improved functionality. However, the treatment choices were not significantly effective in improving muscle force. Trend analysis revealed that in the first and third months, exercise therapy was superior to PRP in pain, shoulder flexion and abduction, and functionality. However, in the sixth month, only shoulder abduction and total Western Ontario Rotator Cuff score were significantly different between the 2 groups. Conclusion: Both PRP injection and exercise therapy were effective in reducing pain and disability in patients with SAIS, with exercise therapy proving more effective.

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BLOOD MANAGEMENT: Large-dose intravenous ferric carboxymaltose injection for iron deficiency anemia in heavy uterine bleeding: a randomized, controlled trial

Transfusion ◽

10.1111/j.1537-2995.2009.02327.x ◽

2009 ◽

Vol 49 (12) ◽

pp. 2719-2728 ◽

Cited By ~ 119

Author(s):

David B. Van Wyck ◽

Antoinette Mangione ◽

John Morrison ◽

Phillip Earl Hadley ◽

Judi A. Jehle ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Iron Deficiency ◽

Iron Deficiency Anemia ◽

Large Dose ◽

Controlled Trial ◽

Uterine Bleeding ◽

Deficiency Anemia ◽

Ferric Carboxymaltose ◽

Blood Management ◽

Randomized Controlled

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Providing information about the effectiveness of treatment options to depressed people in the community: a randomized controlled trial of effects on mental health literacy, help-seeking and symptoms

Psychological Medicine ◽

10.1017/s0033291703008079 ◽

2003 ◽

Vol 33 (6) ◽

pp. 1071-1079 ◽

Cited By ~ 70

Author(s):

A. F. JORM ◽

K. M. GRIFFITHS ◽

H. CHRISTENSEN ◽

A. E. KORTEN ◽

R. A. PARSLOW ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Depressive Symptoms ◽

Help Seeking ◽

Mental Health Literacy ◽

Controlled Trial ◽

Treatment Options ◽

Evidence Based ◽

Symptom Change ◽

Professional Help ◽

Randomized Controlled

Background. Many people who are depressed do not receive any professional help and their beliefs about the helpfulness of treatment do not always correspond with those of health professionals. To facilitate choices about treatment, the present study examined the effects of providing depressed people in the community with evidence on whether various treatment options work.Method. A randomized controlled trial was carried out with 1094 persons selected at random from the community who screened positive for depressive symptoms and agreed to participate. Participants were mailed either an evidence-based consumer guide to treatments for depression or, as a control, a general brochure on depression. Outcomes were the rated usefulness of the information provided, changes in attitudes to depression treatments, actions taken to reduce depression, and changes in depressive symptoms, anxiety symptoms and disability.Results. Participants rated the evidence-based consumer guide as more useful than the control brochure. Attitudes to some treatments changed. Improvements in symptoms and disability did not differ significantly between interventions.Conclusion. Providing people who are depressed with evidence on which treatments work produces some changes in attitudes and behaviour. However, this intervention may need to be enhanced if it is to produce symptom change.

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Developing and Testing the Effectiveness of a Novel Online Integrated Treatment for Problem Gambling and Tobacco Smoking: A Protocol for a Randomized Controlled Trial

10.21203/rs.3.rs-26995/v1 ◽

2020 ◽

Author(s):

Elena Bilevicius ◽

Alanna Single ◽

Chris Baumgartner ◽

Van Bui ◽

Tyler Kempe ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Problem Gambling ◽

Tobacco Smoking ◽

Behavioral Therapy ◽

Controlled Trial ◽

Treatment Options ◽

Integrated Treatment ◽

Randomized Controlled ◽

Secondary Outcomes ◽

Gambling Activities

Abstract Background: Gambling and tobacco smoking are highly comorbid among North American adults. However, there is a paucity of treatment options that are integrated (i.e., targeting both gambling and tobacco smoking simultaneously), accessible, and evidence based.Methods: The aim of this two-arm randomized controlled trial is to examine the effectiveness of an online, self-guided integrated treatment for problem gambling and tobacco smoking. A target sample of 214 participants will be recruited and be randomized into either an eight-week integrated or gambling-only control condition. Both conditions will consist of seven online modules following cognitive behavioral therapy and motivational interviewing principles. Our three primary outcomes are (1) number of days gambled, (2) money spent on gambling activities, and (3) time spent in gambling activities. Secondary outcomes include gambling disorder symptoms, cigarette use, and nicotine dependence symptoms. Assessments will be completed at baseline, at completion (i.e., eight-weeks from baseline), and follow-up (i.e., 24-weeks from baseline). Generalized linear mixed modelling will be used to evaluate our primary and secondary outcomes. We expect that participants receiving online integrated treatment will show larger reductions in gambling relative to those receiving a control gambling only intervention. We further hypothesize that reductions in smoking will mediate these group differences.Discussion: The rates of problem gambling and tobacco smoking are high in North America; yet, the treatment options for both are limited, with no integrated treatments available. If supported, our intervention will be a cost-effective and accessible way to improve treatments for co-occurring problem gambling and tobacco use.Trial registration: Clinicaltrials.gov; ID NCT03614884. Registered August 3, 2019;

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The Effects of Tai Chi on Grade 1 Hypertension: A Study Protocol for a Randomized Controlled Trial

10.21203/rs.2.14023/v2 ◽

2019 ◽

Author(s):

Sang Hyun Lee ◽

Byung-Jun Kim ◽

In-Hwa Park ◽

Eui-Hyoung Hwang ◽

Eun Ju Park ◽

...

Keyword(s):

Blood Pressure ◽

Randomized Controlled Trial ◽

Tai Chi ◽

Salt Intake ◽

Controlled Trial ◽

Treatment Options ◽

Treatment Method ◽

Care Group ◽

Randomized Controlled

Abstract Background Medication is generally recommended to reduce the morbidity and mortality caused by cardiovascular disease in hypertensive patients. However, considering the difficulties and economic factors associated with long-term medication, interest in tai chi as an exercise treatment method has been recently increasing in Korean medical practice. Numerous studies have suggested that tai chi can be used to treat various diseases and affect psychosomatic factors such as anxiety. This study aims to evaluate the effect of tai chi in reducing blood pressure among grade 1 hypertensive patients.Methods In this randomized, active-controlled, assessor-blinded, two parallel-armed trial, 80 grade 1 hypertension patients will be recruited and randomly assigned to the usual care group or to the tai chi group (n = 40 in each group). Subjects who voluntarily signed a study agreement will be educated to manage their own blood pressure by restricting salt intake, losing weight, moderating alcohol consumption, performing exercise, and regulating dietary intake at their first visit. In addition to self-management, the tai chi group will perform two 60-minute tai chi sessions per week for a total of 8 weeks. Blood pressure will be measured as the primary outcome. In addition, body composition, heart rate, and the perceived strength and difficulty of the exercise will be measured as secondary outcomes.Discussion This study intends to conduct a randomized controlled trial of tai chi, which is not widely practiced in Korea. This study will provide valuable data on the effects of tai chi on hypertension, to inform non-pharmaceutical treatment options for this disorder.

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