Faculty Opinions recommendation of Effector functions of human decidual NK cells in healthy early pregnancy are dependent on the specific engagement of natural cytotoxicity receptors.

2009 ◽  
Author(s):  
Ofer Mandelboim
Keyword(s):  
Nk Cells ◽  
Early Pregnancy ◽  
Natural Cytotoxicity ◽  
Effector Functions ◽  
Natural Cytotoxicity Receptors

Effector functions of human decidual NK cells in healthy early pregnancy are dependent on the specific engagement of natural cytotoxicity receptors

2009 ◽  
Vol 82 (2) ◽  
pp. 142-147 ◽  
Author(s):  
Hicham El Costa ◽  
Julie Tabiasco ◽  
Alain Berrebi ◽  
Olivier Parant ◽  
Maryse Aguerre-Girr ◽  
...  
Keyword(s):  
Nk Cells ◽  
Early Pregnancy ◽  
Natural Cytotoxicity ◽  
Effector Functions ◽  
Natural Cytotoxicity Receptors

scholarly journals Influenza A Virus Hemagglutinin and Other Pathogen Glycoprotein Interactions with NK Cell Natural Cytotoxicity Receptors NKp46, NKp44, and NKp30

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 156
Author(s):  
Jasmina M. Luczo ◽  
Sydney L. Ronzulli ◽  
Stephen M. Tompkins
Keyword(s):  
Influenza Virus ◽  
Nk Cells ◽  
Influenza A Virus ◽  
Influenza A ◽  
Nk Cell ◽  
Influenza Virus Infection ◽  
Target Cells ◽  
Natural Cytotoxicity ◽  
Activating Receptors ◽  
Natural Cytotoxicity Receptors

Natural killer (NK) cells are part of the innate immunity repertoire, and function in the recognition and destruction of tumorigenic and pathogen-infected cells. Engagement of NK cell activating receptors can lead to functional activation of NK cells, resulting in lysis of target cells. NK cell activating receptors specific for non-major histocompatibility complex ligands are NKp46, NKp44, NKp30, NKG2D, and CD16 (also known as FcγRIII). The natural cytotoxicity receptors (NCRs), NKp46, NKp44, and NKp30, have been implicated in functional activation of NK cells following influenza virus infection via binding with influenza virus hemagglutinin (HA). In this review we describe NK cell and influenza A virus biology, and the interactions of influenza A virus HA and other pathogen lectins with NK cell natural cytotoxicity receptors (NCRs). We review concepts which intersect viral immunology, traditional virology and glycobiology to provide insights into the interactions between influenza virus HA and the NCRs. Furthermore, we provide expert opinion on future directions that would provide insights into currently unanswered questions.

scholarly journals Human NK Cells Selective Targeting of Colon Cancer–Initiating Cells: A Role for Natural Cytotoxicity Receptors and MHC Class I Molecules

2013 ◽  
Vol 190 (5) ◽  
pp. 2381-2390 ◽  
Author(s):  
Rossana Tallerico ◽  
Matilde Todaro ◽  
Simone Di Franco ◽  
Cristina Maccalli ◽  
Cinzia Garofalo ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Nk Cells ◽  
Mhc Class I ◽  
Class I ◽  
Natural Cytotoxicity ◽  
Selective Targeting ◽  
Natural Cytotoxicity Receptors ◽  
Mhc Class I Molecules

scholarly journals Leukemic Priming of Resting NK Cells Is Killer Ig-like Receptor Independent but Requires CD15-Mediated CD2 Ligation and Natural Cytotoxicity Receptors

2011 ◽  
Vol 187 (12) ◽  
pp. 6227-6234 ◽  
Author(s):  
May Sabry ◽  
Maria Tsirogianni ◽  
Ismail A. Bakhsh ◽  
Janet North ◽  
Janani Sivakumaran ◽  
...  
Keyword(s):  
Nk Cells ◽  
Natural Cytotoxicity ◽  
Natural Cytotoxicity Receptors

scholarly journals Antigen Presenting Cells and Stromal Cells Trigger Human Natural Killer Lymphocytes to Autoreactivity: Evidence for the Involvement of Natural Cytotoxicity Receptors (NCR) and NKG2D

2006 ◽  
Vol 13 (2-4) ◽  
pp. 325-336 ◽  
Author(s):  
Alessandro Poggi ◽  
Maria Raffaella Zocchi
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Stromal Cells ◽  
Viral Infections ◽  
Antigen Presenting Cells ◽  
Cell Interaction ◽  
Natural Cytotoxicity ◽  
Missing Self ◽  
Antigen Presenting ◽  
Natural Cytotoxicity Receptors

Human natural killer (NK) lymphocytes should not damage autologous cells due to the engagement of inhibitory receptor superfamily (IRS) members by HLA-I. Nevertheless, NK cells kill self cells expressing low levels or lacking HLA-I, as it may occur during viral infections (missing-self hypothesis). Herein, we show that human NK cells can be activated upon binding with self antigen presenting cells or stromal cells despite the expression of HLA-I. Indeed, NK cells can kill and produce pro-inflammatory and regulating cytokines as IFN-γ, TNF-α and IL10 during interaction with autologous dendritic cells or bone marrow stromal cells or skin fibroblasts. The killing of antigen presenting and stromal cells is dependent on LFA1/ICAM1 interaction. Further, the natural cytotoxicity receptors (NCR) NKp30 and NKp46 are responsible for the delivery of lethal hit to DC, whereas NKG2D activating receptor, the ligand of the MHC-related molecule MIC-A and the UL16 binding protein, is involved in stromal cell killing. These findings indicate that different activating receptors are involved in cell to self cell interaction. Finally, NK cells can revert the veto effect of stromal cells on mixed lymphocyte reaction further supporting the idea that NK cells may alter the interaction between T lymphocytes and microenvironment leading to autoreactivity.

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