scholarly journals The value of fertility-sparing surgery for young females with epithelial ovarian cancer: a comparative study

2021 ◽  
Vol 19 (1) ◽  
pp. e16-e21
Author(s):  
Waleed M. Etman ◽  
◽  
Mohamed Fathy Abohashim ◽  
Ramadan M. Ali ◽  
Osama Abd-Elaziz ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fertility Preservation ◽  
Radical Surgery ◽  
Survival Rates ◽  
Stage I ◽  
Young Females ◽  
Fertility Sparing Surgery ◽  
Surgery Group ◽  
Fertility Sparing

Background: Epithelial ovarian cancer is increasingly often diagnosed in young females who wish to preserve their fertility. Fertilitypreserving surgeries, where conservation of the uterus and contralateral ovary was performed, might be beneficial for patients with stage I epithelial ovarian cancer, but their safety is still controversial. In the present study, we aimed to compare radical surgery and fertility-saving surgery in females with stage IA–C epithelial ovarian cancer for recurrence and survival rates, as well as to evaluate reproductive and obstetric outcomes for stage I epithelial ovarian cancer females who were managed with fertility-saving surgery. Materials and methods: We prospectively identified 60 patients aged ≤40 years who were diagnosed with stage I epithelial ovarian cancer. The patients in the fertility-preservation group underwent salpingo-oophorectomy on the side of the affected ovary in addition to incisional biopsy or wedge excision of the ovary on the other side. The patients in the radical surgery group underwent total hysterectomy and bilateral salpingo-oophorectomy. We followed up all patients for 5 years to assess their reproductive and oncological outcomes. Results: Patients in the fertility preservation surgery group were significantly younger (30 ± 4 versus 35 ± 5 years) (p < 0.001), their tumor sizes were smaller (3.4 ± 1.3 versus 6.0 ± 2.6 cm) (p < 0.001), of lower grade (p = 0.011), earlier stage (p < 0.001) and had more mucinous histology than patients in the radical surgery group. There were no statistically significant differences between both groups regarding tumor recurrence or survival rates. Of 25 patients who underwent fertility preservation surgery, 18 (72%) attempted to conceive. A total of 15/18 (83%) pregnancies were recorded, including 13 live births, 1 miscarriage, and 1 intrauterine fetal death. Conclusion: Fertility-sparing surgery could be an adequate alternative to radical surgery for young females with stage I epithelial ovarian cancer.

scholarly journals Postrecurrence Clinical Outcome of Patients with Stage I Epithelial Ovarian Cancer Who Underwent Fertility-Sparing Surgery Compared to Those with Radical Surgery

2013 ◽  
Vol 04 (01) ◽  
pp. 118-124
Author(s):  
Hiroaki Kajiyama ◽  
Kiyosumi Shibata ◽  
Mika Mizuno ◽  
Eiko Yamamoto ◽  
Michiyasu Kawai ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Clinical Outcome ◽  
Epithelial Ovarian Cancer ◽  
Radical Surgery ◽  
Stage I ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

All-Cause Mortality After Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer

2017 ◽  
Vol 72 (12) ◽  
pp. 713-715
Author(s):  
Alexander Melamed ◽  
Anthony E. Rizzo ◽  
Roni Nitecki ◽  
Allison A. Gockley ◽  
Amy J. Bregar ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Stage I ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
All Cause Mortality

Outcomes of Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer: A Proposal for Patient Selection

2010 ◽  
Vol 28 (10) ◽  
pp. 1727-1732 ◽  
Author(s):  
Toyomi Satoh ◽  
Masayuki Hatae ◽  
Yoh Watanabe ◽  
Nobuo Yaegashi ◽  
Osamu Ishiko ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Clear Cell ◽  
Stage I ◽  
Healthy Children ◽  
Favorable Histology ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Stage Ia ◽  
Grade 3

Purpose The objective of this study was to assess clinical outcomes and fertility in patients treated conservatively for unilateral stage I invasive epithelial ovarian cancer (EOC). Patients and Methods A multi-institutional retrospective investigation was undertaken to identify patients with unilateral stage I EOC treated with fertility-sparing surgery. Favorable histology was defined as grade 1 or grade 2 adenocarcinoma, excluding clear cell histology. Results A total of 211 patients (stage IA, n = 126; stage IC, n = 85) were identified from 30 institutions. Median duration of follow-up was 78 months. Five-year overall survival and recurrence-free survival were 100% and 97.8% for stage IA and favorable histology (n = 108), 100% and 100% for stage IA and clear cell histology (n = 15), 100% and 33.3% for stage IA and grade 3 (n = 3), 96.9% and 92.1% for stage IC and favorable histology (n = 67), 93.3% and 66.0% for stage IC and clear cell histology (n = 15), and 66.7% and 66.7% for stage IC and grade 3 (n = 3). Forty-five (53.6%) of 84 patients who were nulliparous at fertility-sparing surgery and married at the time of investigation gave birth to 56 healthy children. Conclusion Our data confirm that fertility-sparing surgery is a safe treatment for stage IA patients with favorable histology and suggest that stage IA patients with clear cell histology and stage IC patients with favorable histology can be candidates for fertility-sparing surgery followed by adjuvant chemotherapy.

scholarly journals Methods and conditions of fertility preservation in early-stage ovarian tumors

2013 ◽  
Vol 154 (14) ◽  
pp. 523-530
Author(s):  
Erzsébet Szatmári ◽  
Szabolcs Máté ◽  
Norbert Sipos ◽  
András Szánthó ◽  
Mihály Silhavy ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Fertility Preservation ◽  
Early Stage ◽  
Ovarian Tumors ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Stage Ia ◽  
Grade 3

The aim of this study is to review the literature of fertility-sparing techniques and their safety in early-stage malignant ovarian tumors, especially in epithelial ovarian cancer. Fertility preservation is widely accepted in early-stage borderline, germ cell and sex cord-stromal tumors. Based on data from retrospective studies, fertility-sparing surgery in epithelial ovarian cancer can be recommended in stage IA, grade 1–2 and favorable hystologic type ovarian cancer. Above stage IA, or in grade 3, or in clear-cell tumors decision making process about fertility-sparing surgery should be individual. Correct surgical staging is mandatory and oncologic safety should be primary. In the group of carefully selected patients oncological outcomes are identical to those of radical surgery. Spontaneous pregnancy rates vary, but they are generally high. Adequate counseling with patients, detailed documentation and careful follow-up is of outstanding importance. In order to improve the quality of fertility preservation techniques, establishment of treatment centers is recommended. Orv. Hetil., 2013, 154, 523–530.

All-Cause Mortality After Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer

2017 ◽  
Vol 130 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Alexander Melamed ◽  
Anthony E. Rizzo ◽  
Roni Nitecki ◽  
Allison A. Gockley ◽  
Amy J. Bregar ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Stage I ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
All Cause Mortality

scholarly journals Clinical and reproductive outcomes of fertility‑sparing surgery in stage�I epithelial ovarian cancer

2019 ◽  
Author(s):  
Takafumi Watanabe ◽  
Shu Soeda ◽  
Hiroshi Nishiyama ◽  
Yuichiroh Kiko ◽  
Hideki Tokunaga ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Stage I ◽  
Reproductive Outcomes ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing

Fertility preservation in women with early ovarian cancer

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Daniel Necula ◽  
Daria Istrate ◽  
Jérôme Mathis
Keyword(s):  
Ovarian Cancer ◽  
Fertility Preservation ◽  
Low Grade ◽  
Term Survival ◽  
Organizational Issues ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Early Ovarian Cancer ◽  
Reproductive Techniques

AbstractFertility preservation is an important option to consider for young women with low-grade early ovarian cancer. Fertility-sparing surgery (“FSS”) permits the conservation of the uterus and one of the ovaries. This technique is considered safe for stages IA G1, G2 and probably safe for IC G1 epithelial and non-epithelial ovarian cancers. There are still uncertainties and FSS is not fully accepted for stage IC G1, G2 and clear cell carcinoma. The difficulty in choosing the best option lies in the fact that there is a lack of prospective randomized studies, due to ethical and organizational issues. Retrospective studies and reviews showed reassuring results for FSS in terms of relapse and long term survival. The spontaneous pregnancy rate seems to decrease after FSS, but chemotherapy does not seem to have an impact on fertility rates. Compared with the general population, assisted reproductive techniques are considered safe and with similar fertility results.

Sign in / Sign up

Export Citation Format

Share Document