Faculty Opinions recommendation of Calcium-phosphate matrix with or without TGF-β3 improves tendon-bone healing after rotator cuff repair.

2011 ◽  
Author(s):  
Anthony Ratcliffe
Keyword(s):  
Calcium Phosphate ◽  
Rotator Cuff ◽  
Bone Healing ◽  
Rotator Cuff Repair ◽  
Cuff Repair

Calcium-Phosphate Matrix With or Without TGF-β3Improves Tendon-Bone Healing After Rotator Cuff Repair

2011 ◽  
Vol 39 (4) ◽  
pp. 811-819 ◽  
Author(s):  
David Kovacevic ◽  
Alice J. Fox ◽  
Asheesh Bedi ◽  
Liang Ying ◽  
Xiang-Hua Deng ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Rotator Cuff ◽  
Bone Healing ◽  
Rotator Cuff Repair ◽  
Cuff Repair

scholarly journals TOB1 Deficiency Enhances the Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Tendon-Bone Healing in a Rat Rotator Cuff Repair Model

2016 ◽  
Vol 38 (1) ◽  
pp. 319-329 ◽  
Author(s):  
Yulei Gao ◽  
Yinquan Zhang ◽  
Yanghu Lu ◽  
Yi Wang ◽  
Xingrui Kou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Rotator Cuff ◽  
Bone Healing ◽  
Rotator Cuff Repair ◽  
Collagen Type ◽  
Collagen Type I ◽  
Type I ◽  
Cuff Repair

Background/Aims: This study investigated the effect of silencing TOB1 (Transducer of ERBB2, 1) expression in bone marrow-derived mesenchymal stem cells (MSCs) on MSC-facilitated tendon-bone healing in a rat supraspinatus repair model. Methods: Rat MSCs were transduced with a recombinant lentivirus encoding short hairpin RNA (shRNA) against TOB1. MSC cell proliferation was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. The effect of MSCs with TOB1 deficiency on tendon-bone healing in a rat rotator cuff repair model was evaluated by biomechanical testing, histological analysis and collagen type I and II gene expression. An upstream regulator (miR-218) of TOB1 was determined in MSCs. Results: We found that knockdown of TOB1 significantly increased the proliferative activity of rat MSCs in vitro. When MSCs with TOB1 deficiency were injected into injured rat supraspinatus tendon-bone junctions, the effect on tendon-bone healing was enhanced compared to treatment with control MSCs with normal TOB1 expression, as evidenced by elevated levels of ultimate load to failure and stiffness, increased amount of fibrocartilage and augmented expression of collagen type I and type II genes. In addition, we found that the TOB1 3′ untranslated region is a direct target of miR-218. Similar to the effect of TOB1 deficiency, overexpression of miR-218 effectively promoted tendon-bone healing in rat. Conclusion: These results suggest that TOB1 may play a negative role in the effect of MSCs on tendon-bone healing, and imply that expression of TOB1 may be regulated by miR-218.

scholarly journals Postoperative Tendon Loading With Treadmill Running Delays Tendon‐to‐Bone Healing: Immunohistochemical Evaluation in a Murine Rotator Cuff Repair Model

2019 ◽  
Vol 37 (7) ◽  
pp. 1628-1637 ◽  
Author(s):  
Susumu Wada ◽  
Amir H. Lebaschi ◽  
Yusuke Nakagawa ◽  
Camila B. Carballo ◽  
Tyler J. Uppstrom ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Bone Healing ◽  
Rotator Cuff Repair ◽  
Treadmill Running ◽  
Cuff Repair

scholarly journals Is a Local Administration of Parathyroid Hormone Effective to Tendon‐to‐Bone Healing in a Rat Rotator Cuff Repair Model?

2019 ◽  
Vol 38 (1) ◽  
pp. 82-91 ◽  
Author(s):  
Jong Pil Yoon ◽  
Seok Won Chung ◽  
Jae Wook Jung ◽  
Yong‐Soo Lee ◽  
Kwang‐Il Kim ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Rotator Cuff ◽  
Bone Healing ◽  
Rotator Cuff Repair ◽  
Local Administration ◽  
Cuff Repair

scholarly journals Pulsed electromagnetic field therapy improves tendon-to-bone healing in a rat rotator cuff repair model

2016 ◽  
Vol 35 (4) ◽  
pp. 902-909 ◽  
Author(s):  
Jennica J. Tucker ◽  
James M. Cirone ◽  
Tyler R. Morris ◽  
Courtney A. Nuss ◽  
Julianne Huegel ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
Rotator Cuff ◽  
Bone Healing ◽  
Rotator Cuff Repair ◽  
Pulsed Electromagnetic Field ◽  
Field Therapy ◽  
Pulsed Electromagnetic ◽  
Pulsed Electromagnetic Field Therapy ◽  
Cuff Repair

TNF-alpha Blockade Improves Early Tendon-to-Bone Healing in a Rat Rotator Cuff Repair Model (SS-10)

2009 ◽  
Vol 25 (6) ◽  
pp. e5-e6 ◽  
Author(s):  
Lawrence V. Gulotta ◽  
David Kovacevic ◽  
Frank A. Cordasco ◽  
Scott A. Rodeo
Keyword(s):  
Rotator Cuff ◽  
Bone Healing ◽  
Rotator Cuff Repair ◽  
Tnf Alpha ◽  
Alpha Blockade ◽  
Cuff Repair

Effect of Footprint Preparation on Tendon-to-Bone Healing: A Histologic and Biomechanical Study in a Rat Rotator Cuff Repair Model

2017 ◽  
Vol 33 (8) ◽  
pp. 1482-1492 ◽  
Author(s):  
Haruhiko Nakagawa ◽  
Toru Morihara ◽  
Hiroyoshi Fujiwara ◽  
Yukichi Kabuto ◽  
Tsuyoshi Sukenari ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Bone Healing ◽  
Rotator Cuff Repair ◽  
Biomechanical Study ◽  
Cuff Repair
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