Faculty Opinions recommendation of Predictive value of the high-sensitivity troponin T assay and the simplified Pulmonary Embolism Severity Index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study.

2012 ◽  
Author(s):  
Patrick Ray
Keyword(s):  
Pulmonary Embolism ◽  
Validation Study ◽  
Predictive Value ◽  
Acute Pulmonary Embolism ◽  
Troponin T ◽  
High Sensitivity ◽  
Severity Index ◽  
High Sensitivity Troponin ◽  
High Sensitivity Troponin T

scholarly journals Age-adjusted high-sensitivity troponin T cut-off value for risk stratification of pulmonary embolism

2015 ◽  
Vol 45 (5) ◽  
pp. 1323-1331 ◽  
Author(s):  
Anja Kaeberich ◽  
Valerie Seeber ◽  
David Jiménez ◽  
Maciej Kostrubiec ◽  
Claudia Dellas ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Adverse Outcome ◽  
Troponin T ◽  
High Sensitivity ◽  
Severity Index ◽  
Characteristic Analysis ◽  
Prognostic Information ◽  
High Sensitivity Troponin ◽  
Advanced Therapy ◽  
High Sensitivity Troponin T

High-sensitivity troponin T (hsTnT) helps in identifying pulmonary embolism patients at low risk of an adverse outcome. In 682 normotensive pulmonary embolism patients we investigate whether an optimised hsTnT cut-off value and adjustment for age improve the identification of patients at elevated risk.Overall, 25 (3.7%) patients had an adverse 30-day outcome. The established hsTnT cut-off value of 14 pg·mL−1 retained its high prognostic value (OR (95% CI) 16.64 (2.24–123.74); p=0.006) compared with the cut-off value of 33 pg·mL−1 calculated by receiver operating characteristic analysis (7.14 (2.64–19.26); p<0.001). In elderly (aged ≥75 years) patients, an age-optimised hsTnT cut-off value of 45 pg·mL−1 but not the established cut-off value of 14 pg·mL−1 predicted an adverse outcome. An age-adjusted hsTnT cut-off value (≥14 pg·mL−1 for patients aged <75 years and ≥45 pg·mL−1 for patients aged ≥75 years) provided additive and independent prognostic information on top of the simplified pulmonary embolism severity index (sPESI) and echocardiography (OR 4.56 (1.30–16.01); p=0.018, C-index=0.77). A three-step approach based on the sPESI, hsTnT and echocardiography identified 16.6% of all patients as being at higher risk (12.4% adverse outcome).Risk assessment of normotensive pulmonary embolism patients was improved by the introduction of an age-adjusted hsTnT cut-off value. A three-step approach helped identify patients at higher risk of an adverse outcome who might benefit from advanced therapy.

scholarly journals Predictive value of high-sensitivity troponin I and D-dimer assays for adverse outcome in patients with acute pulmonary embolism

2012 ◽  
Vol 5 (2) ◽  
pp. 586-590 ◽  
Author(s):  
THOMAS WALTER ◽  
PAUL APFALTRER ◽  
FRANK WEILBACHER ◽  
MATHIAS MEYER ◽  
STEFAN O. SCHOENBERG ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Predictive Value ◽  
Acute Pulmonary Embolism ◽  
Troponin I ◽  
Adverse Outcome ◽  
High Sensitivity ◽  
High Sensitivity Troponin ◽  
D Dimer

scholarly journals Predictive value of high-sensitivity troponin T in addition to EuroSCORE II in cardiac surgery

2016 ◽  
Vol 23 (1) ◽  
pp. 133-141 ◽  
Author(s):  
Liisa Petäjä ◽  
Helge Røsjø ◽  
Leena Mildh ◽  
Raili Suojaranta-Ylinen ◽  
Kirsi-Maija Kaukonen ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Predictive Value ◽  
Troponin T ◽  
High Sensitivity ◽  
High Sensitivity Troponin ◽  
High Sensitivity Troponin T

scholarly journals Predictive value of positive high-sensitivity troponin T in intubated traumatic brain injury patients

2018 ◽  
Vol 129 (6) ◽  
pp. 1541-1549 ◽  
Author(s):  
Ayman El-Menyar ◽  
Mohammad Asim ◽  
Rifat Latifi ◽  
Shrikant I. Bangdiwala ◽  
Hassan Al-Thani
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Predictive Value ◽  
Troponin T ◽  
National Level ◽  
High Sensitivity ◽  
High Sensitivity Troponin ◽  
Group 2 ◽  
High Sensitivity Troponin T ◽  
Group 1

OBJECTIVEThe clinical relevance of high-sensitivity troponin T (HsTnT) in trauma patients is not well explored. In this study, the authors aimed to study the predictive value of serum HsTnT in intubated patients who had sustained traumatic brain injury (TBI).METHODSA retrospective analysis was conducted for all intubated TBI patients between 2010 and 2014 at a national level 1 trauma center. Data were analyzed and compared based on the HsTnT status on admission (group 1, negative results; and group 2, positive results). Receiver operating characteristic curves were used to determine sensitivity, specificity, and cutoff level of HsTnT to predict mortality. Time to earlier discharge from hospital or death was modeled using Cox proportional hazard models to describe the relationship between HsTnT and in-hospital mortality.RESULTSOf the 826 intubated TBI patients, 490 underwent HsTnT testing; 65.7% had positive HsTnT results. Patients in group 2 had a higher Injury Severity Score (p = 0.001) and head Abbreviated Injury Scale (AIS) score (p = 0.004) than those in group 1. In addition, group 2 patients were more likely to have lower Glasgow Coma Scale scores (p = 0.001) and more likely to experience intraventricular hemorrhage, brain edema, pneumonia, and sepsis (p = 0.001). HsTnT values positively correlated with head AIS score (r = 0.19, p = 0.001) and varied by the type of lesion and time to death. Ventilator days and length of hospital stay were more prolonged in group 2 patients (p = 0.001). Area under the curve (AUC) analysis showed that HsTnT ≥ 26.5 ng/L predicted all-cause mortality (AUC 0.75, 95% CI 0.699–0.801) with 80% sensitivity. Positive HsTnT was an independent predictor of mortality in multivariate models (adjusted OR 3.10, 95% CI 1.308–7.351) even after excluding chest injury (adjusted OR 4.18, 95% CI 1.320–13.231).CONCLUSIONSPositive HsTnT results are associated with poor outcomes in intubated patients with TBI. In this subset of patients, measuring serum HsTnT on admission is a useful tool for early risk stratification and expedited care; however, further prospective studies are warranted.

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