Faculty Opinions recommendation of Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.

2012 ◽  
Author(s):  
Thomas Pap ◽  
Marianne Heitzmann
Keyword(s):  
Ligand Binding ◽  
Wnt Proteins ◽  
Binding Regions

scholarly journals Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

2010 ◽  
Vol 107 (35) ◽  
pp. 15473-15478 ◽  
Author(s):  
S. A. Ettenberg ◽  
O. Charlat ◽  
M. P. Daley ◽  
S. Liu ◽  
K. J. Vincent ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Wnt Proteins ◽  
Binding Regions

scholarly journals Sensing of environmental signals: classification of chemoreceptors according to the size of their ligand binding regions

2010 ◽  
Vol 12 (11) ◽  
pp. 2873-2884 ◽  
Author(s):  
Jesús Lacal ◽  
Cristina García-Fontana ◽  
Francisco Muñoz-Martínez ◽  
Juan-Luis Ramos ◽  
Tino Krell
Keyword(s):  
Ligand Binding ◽  
Environmental Signals ◽  
Binding Regions

Frequent mutations in NOTCH1 ligand-binding regions in Japanese oral squamous cell carcinoma

2014 ◽  
Vol 452 (4) ◽  
pp. 980-985 ◽  
Author(s):  
Ken-ichi Aoyama ◽  
Yoshihide Ota ◽  
Kagemasa Kajiwara ◽  
Noriaki Hirayama ◽  
Minoru Kimura
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Ligand Binding ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Binding Regions ◽  
Frequent Mutations

Identification of Ligand Binding Regions of theSaccharomyces cerevisiaeα-Factor Pheromone Receptor by Photoaffinity Cross-Linking†

Biochemistry ◽  
2004 ◽  
Vol 43 (41) ◽  
pp. 13193-13203 ◽  
Author(s):  
Cagdas D. Son ◽  
Hasmik Sargsyan ◽  
Fred Naider ◽  
Jeffrey M. Becker
Keyword(s):  
Ligand Binding ◽  
Cross Linking ◽  
Pheromone Receptor ◽  
Binding Regions

scholarly journals Ligand Binding Regions in the Receptor for Urokinase-type Plasminogen Activator

2001 ◽  
Vol 276 (31) ◽  
pp. 28946-28953 ◽  
Author(s):  
Olin D. Liang ◽  
Triantafyllos Chavakis ◽  
Sandip M. Kanse ◽  
Klaus T. Preissner
Keyword(s):  
Ligand Binding ◽  
Plasminogen Activator ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Binding Regions

scholarly journals Evasion of Phagocytosis through Cooperation between Two Ligand-binding Regions in Streptococcus pyogenes M Protein

2003 ◽  
Vol 198 (7) ◽  
pp. 1057-1068 ◽  
Author(s):  
Fredric Carlsson ◽  
Karin Berggård ◽  
Margaretha Stålhammar-Carlemalm ◽  
Gunnar Lindahl
Keyword(s):  
Ligand Binding ◽  
Streptococcus Pyogenes ◽  
M Protein ◽  
Classical Pathway ◽  
Human Immune System ◽  
M Proteins ◽  
Binding Regions ◽  
Protective Antibodies ◽  
Bacterial Virulence Factor

The M protein of Streptococcus pyogenes is a major bacterial virulence factor that confers resistance to phagocytosis. To analyze how M protein allows evasion of phagocytosis, we used the M22 protein, which has features typical of many M proteins and has two well-characterized regions binding human plasma proteins: the hypervariable NH2-terminal region binds C4b-binding protein (C4BP), which inhibits the classical pathway of complement activation; and an adjacent semivariable region binds IgA-Fc. Characterization of chromosomal S. pyogenes mutants demonstrated that each of the ligand-binding regions contributed to phagocytosis resistance, which could be fully explained as cooperation between the two regions. Deposition of complement on S. pyogenes occurred almost exclusively via the classical pathway, even under nonimmune conditions, but was down-regulated by bacteria-bound C4BP, providing an explanation for the ability of bound C4BP to inhibit phagocytosis. Different opsonizing antisera shared the ability to block binding of both C4BP and IgA, suggesting that the two regions in M22 play important roles also under immune conditions, as targets for protective antibodies. These data indicate that M22 and similar M proteins confer resistance to phagocytosis through ability to bind two components of the human immune system.

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