Faculty Opinions recommendation of A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese.

ABSTRACTSubstantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium. The SNP heritability of total psychiatric problems was 5.4% (SE=0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total psychiatric problem score were shared with known genetic variants for common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation of with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29).The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between psychiatric disorders and related traits.

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Detection of genetic variants affecting cattle behaviour and their impact on milk production: a genome-wide association study

Animal Genetics ◽

10.1111/age.12371 ◽

2015 ◽

Vol 47 (1) ◽

pp. 12-18 ◽

Cited By ~ 7

Author(s):

Juliane Friedrich ◽

Bodo Brand ◽

Siriluck Ponsuksili ◽

Katharina L. Graunke ◽

Jan Langbein ◽

...

Keyword(s):

Association Study ◽

Milk Production ◽

Genetic Variants ◽

Genome Wide Association Study ◽

Genome Wide Association ◽

Genome Wide ◽

A Genome

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A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank

Human Molecular Genetics ◽

10.1093/hmg/ddaa058 ◽

2020 ◽

Vol 29 (8) ◽

pp. 1396-1404 ◽

Cited By ~ 2

Author(s):

Weihua Meng ◽

Brian W Chan ◽

Cameron Harris ◽

Maxim B Freidin ◽

Harry L Hebert ◽

...

Keyword(s):

Association Study ◽

Shoulder Pain ◽

Genetic Variants ◽

Genome Wide Association Study ◽

Genome Wide Association ◽

Uk Biobank ◽

Genome Wide ◽

A Genome ◽

Significant Locus ◽

The Uk

Abstract Background Common types of musculoskeletal conditions include pain in the neck and shoulder areas. This study seeks to identify the genetic variants associated with neck or shoulder pain based on a genome-wide association approach using 203 309 subjects from the UK Biobank cohort and look for replication evidence from the Generation Scotland: Scottish Family Health Study (GS:SFHS) and TwinsUK. Methods A genome-wide association study was performed adjusting for age, sex, BMI and nine population principal components. Significant and independent genetic variants were then sent to GS:SFHS and TwinsUK for replication. Results We identified three genetic loci that were associated with neck or shoulder pain in the UK Biobank samples. The most significant locus was in an intergenic region in chromosome 17, rs12453010, having P = 1.66 × 10−11. The second most significant locus was located in the FOXP2 gene in chromosome 7 with P = 2.38 × 10−10 for rs34291892. The third locus was located in the LINC01572 gene in chromosome 16 with P = 4.50 × 10−8 for rs62053992. In the replication stage, among four significant and independent genetic variants, rs2049604 in the FOXP2 gene and rs62053992 in the LINC01572 gene were weakly replicated in GS:SFHS (P = 0.0240 and P = 0.0202, respectively). Conclusions We have identified three loci associated with neck or shoulder pain in the UK Biobank cohort, two of which were weakly supported in a replication cohort. Further evidence is needed to confirm their roles in neck or shoulder pain.

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