Faculty Opinions recommendation of Nomograms for predicting changes in semen parameters in infertile men after varicocele repair.

Обследованы 19 мужчин с нарушением фертильности, носителей транслокаций rob(13;14) и rob(13;15). Показано, что нарушение репродуктивной функции обусловлено блоком сперматогенеза в профазе I мейоза, приводящего к азооспермии или олигоастенотератозооспермии и мужскому бесплодию. We examined 19 infertile men, carriers of translocations rob (13;14) and rob (13;15). We assume that fertility problems are resulted from spermatogenesis impairment because of meiotic arrest at prophase I stages, that leads to azoospermia or oligoastenoteratozoospermia and male infertility.

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The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18115977 ◽

2021 ◽

Vol 18 (11) ◽

pp. 5977

Author(s):

Kamil Gill ◽

Michal Kups ◽

Patryk Harasny ◽

Tomasz Machalowski ◽

Marta Grabowska ◽

...

Keyword(s):

Reduction Potential ◽

Nuclear Dna ◽

Study Groups ◽

Semen Parameters ◽

Sperm Dna Fragmentation ◽

Control Groups ◽

Infertile Men ◽

Oxidation Reduction ◽

Oxidation Reduction Potential ◽

Sperm Dna

Since varicocele is so common in infertile men, this study intends to analyse the relationships between varicocele and conventional semen characteristics, sperm nuclear DNA dispersion and oxidation-reduction potential (ORP) in semen. Varicocele-positive and varicocele-negative infertile men (study groups) showed significantly lower standard sperm parameters and higher sperm DNA fragmentation (SDF) and ORP in semen than healthy volunteers and subjects with proven fertility (control groups). A lower proportion of low SDF levels (0–15% SDF) and higher incidence of high SDF levels (>30% SDF), as well as a higher prevalence of high ORP values (>1.37 mV/106 sperm/mL), were found in the study groups vs. the control groups. Moreover, infertile men had significantly lower odds ratios (ORs) for low SDF levels and significantly higher ORs for high SDF levels and high ORP. SDF and ORP were negatively correlated with sperm number, morphology, motility and vitality. Furthermore, a significant positive correlation was found between SDF and ORP. The obtained results suggest that disorders of spermatogenesis may occur in varicocele-related infertility. These abnormalities are manifested not only by reduced standard semen parameters but also by decreased sperm DNA integrity and simultaneously increased oxidative stress in semen.

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Association among sperm chromatin condensation, sperm DNA fragmentation and 8‐OHdG in seminal plasma and semen parameters in infertile men with oligoasthenoteratozoospermia

Andrologia ◽

10.1111/and.14268 ◽

2021 ◽

Author(s):

Dilara Hologlu ◽

Sezgin Gunes ◽

Ramazan Asci ◽

Ralf Henkel ◽

Tolga Guvenc

Keyword(s):

Dna Fragmentation ◽

Seminal Plasma ◽

Chromatin Condensation ◽

Semen Parameters ◽

Sperm Chromatin ◽

Sperm Dna Fragmentation ◽

Infertile Men ◽

Sperm Dna ◽

Sperm Chromatin Condensation

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Is there a place for nutritional supplements in the treatment of idiopathic male infertility?

Archivio Italiano di Urologia e Andrologia ◽

10.4081/aiua.2014.3.164 ◽

2014 ◽

Vol 86 (3) ◽

pp. 164 ◽

Cited By ~ 16

Author(s):

Davide Arcaniolo ◽

Vincenzo Favilla ◽

Daniele Tiscione ◽

Francesca Pisano ◽

Giorgio Bozzini ◽

...

Keyword(s):

Male Infertility ◽

Sperm Count ◽

Nutritional Supplements ◽

Semen Parameters ◽

Male Factor ◽

Treatment Regimens ◽

Idiopathic Male Infertility ◽

Infertile Men ◽

Wide Variability

Objective: Infertility affects 15% of couples in fertile age. Male factor is a cause of infertility in almost half of cases, mainly due to oligoasthenoteratozoospermia (OAT). The purpose of this study is to review the effects of nutritional supplements as medical treatment for idiopathic male infertility. Material and methods: A Pub Med and Medline review of the published studies utilizing nutritional supplements for the treatment of male infertility has been performed. Results: Clinical trials on Vitamin E, Vitamin A, Vitamin C. Arginine, Carnitine, N-Acetyl-Carnitine, Glutathione, Coenzyme Q10, Selenium and Zinc were reviewed. Although there is a wide variability in selected population, dose regimen and final outcomes, nutritional supplements both alone and in combination seems to be able to improve semen parameters (sperm count, sperm motility and morphology) and pregnancy rate in infertile men. Conclusions: There are rising evidences from published randomized trials and systematic review suggesting that nutritional supplementation may improve semen parameters and the likelihood of pregnancy in men affected by OAT. This improvement, however, is not consistent and there is a wide variation in the treatment regimens used. Well designed and adequately powered RCTs are needed to better clarify the role of nutritional supplements as treatment for male infertility.

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Antisperm antibodies in infertile men and their effect on semen parameters: A systematic review and meta-analysis

Clinica Chimica Acta ◽

10.1016/j.cca.2015.01.033 ◽

2015 ◽

Vol 444 ◽

pp. 29-36 ◽

Cited By ~ 35

Author(s):

Dong Cui ◽

Gangwei Han ◽

Yonggang Shang ◽

Chengcheng Liu ◽

Liubing Xia ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Semen Parameters ◽

Antisperm Antibodies ◽

Infertile Men

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Varicocele repair improves semen parameters in azoospermic men with Sertoli cell-only syndrome.

Fertility and Sterility ◽

10.1016/s0015-0282(01)02571-7 ◽

2001 ◽

Vol 76 (3) ◽

pp. S192

Author(s):

F.F Pasqualotto ◽

J Hallak ◽

A.M Lucon ◽

J.R Colombo ◽

L.B Saldanha ◽

...

Keyword(s):

Sertoli Cell ◽

Semen Parameters ◽

Varicocele Repair

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110 EFFICACY OF SELENIUM OR N-ACETYL-CYSTEINE, SEPARATELY OR IN COMBINATION IN IMPROVING SEMEN PARAMETERS IN INFERTILE MEN: A DOUBLE BLIND, PLACEBO-CONTROLLED, RANDOMIZED STUDY

European Urology Supplements ◽

10.1016/s1569-9056(09)60116-0 ◽

2009 ◽

Vol 8 (4) ◽

pp. 148

Author(s):

M.R. Safarinejad

Keyword(s):

Randomized Study ◽

Semen Parameters ◽

Double Blind ◽

Double Blind Placebo ◽

Infertile Men ◽

Acetyl Cysteine

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Association of Vitamin D Status with Semen Parameters and Male Reproductive Hormones in Egyptian Infertile Men

Austin Andrology ◽

10.26420/austinandrology.2021.1028 ◽

2021 ◽

Vol 5 (1) ◽

Author(s):

Doaa Abou-Taleb AE ◽

◽

Mahran AM ◽

Mahmoud MA ◽

Gaber MA ◽

...

Keyword(s):

Vitamin D ◽

Significant Positive Correlation ◽

Reproductive Hormones ◽

Male Reproduction ◽

Semen Parameters ◽

Unknown Etiology ◽

Control Group ◽

Positive Correlation ◽

Infertile Men

Background: Although vitamin D receptor (VDR) is expressed in human sperm, little is known about the role of vitamin D (Vit. D) in male reproduction. Our objective was to assess Vit. D levels both in serum and seminal fluid and to establish the relation between serum and seminal Vit. D levels, semen parameters, male sex hormones and serum calcium level in Egyptian infertile men. Patients and Methods: We conducted a prospective case control study including 30 healthy fertile males as a control group and 60 male patients with infertility of unknown etiology. Semen samples were collected and semen parameters were evaluated. Also, seminal Vit. D level was measured. Blood samples were taken as serum levels of Vit. D, calcium, testosterone, Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) were estimated. Results: There was significant decrease of both serum and seminal Vit. D level in groups of male infertility compared to control group. A significant positive correlation was found between serum and seminal Vit. D levels in different study groups. Also, significant positive correlation between serum Vit. D level and non-progressive sperm motility. Conclusion: Our results support the role of Vit. D in semen parameters and male fertility status.

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