Faculty Opinions recommendation of Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity.

2016 ◽  
Author(s):  
Manuel Corpas
Keyword(s):  
Human Longevity ◽  
Related Disease ◽  
Age Related ◽  
Genome Wide ◽  
Genome Wide Scan

scholarly journals A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120388 ◽  
Author(s):  
Fu-Hui Xiao ◽  
Yong-Han He ◽  
Qi-Gang Li ◽  
Huan Wu ◽  
Long-Hai Luo ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Human Longevity ◽  
Disease Genes ◽  
Related Disease ◽  
Age Related ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Scan

scholarly journals Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity

PLoS Genetics ◽  
2015 ◽  
Vol 11 (12) ◽  
pp. e1005728 ◽  
Author(s):  
Kristen Fortney ◽  
Edgar Dobriban ◽  
Paolo Garagnani ◽  
Chiara Pirazzini ◽  
Daniela Monti ◽  
...  
Keyword(s):  
Human Longevity ◽  
Related Disease ◽  
Age Related ◽  
Genome Wide ◽  
Genome Wide Scan

scholarly journals A joint analysis of longevity and age-related disease variants for gene expression association

2021 ◽  
Author(s):  
Lu Zeng ◽  
Shouneng Peng ◽  
Seungsoo Kim ◽  
Jun Zhu ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Genetic Variants ◽  
Gene Expression Regulation ◽  
Human Longevity ◽  
Joint Analysis ◽  
Putative Gene ◽  
Related Disease ◽  
Age Related ◽  
Genome Wide

AbstractA large number of genetic variants associated with human longevity have been reported but how they play their functions remains elusive. We performed an integrative analysis on 113 genome-wide significant longevity and 14,529 age-related disease variants in the context of putative gene expression regulation. We found that most of the longevity allele types were different from the genotype of disease alleles when they were localized at the same chromosomal positions. Longevity variants were about eight times more likely to be associated with gene expression than randomly selected variants. The directions of the gene expression association were more likely to be opposite between longevity and disease variants when the association occurred to the same gene. Many longevity variants likely function through down-regulating inflammatory response and up-regulating healthy lipid metabolisms. In conclusion, this work helps to elucidate the potential mechanisms of longevity variants for follow-up studies to discover methods to extend human healthspan.

Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions

2001 ◽  
Vol 132 (5) ◽  
pp. 682-692 ◽  
Author(s):  
Daniel E Weeks ◽  
Yvette P Conley ◽  
Hui-ju Tsai ◽  
Tammy S Mah ◽  
Philip J Rosenfeld ◽  
...  
Keyword(s):  
Susceptibility Loci ◽  
Age Related ◽  
Genome Wide ◽  
Genome Wide Scan

scholarly journals The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

Genes ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 222 ◽  
Author(s):  
Paolo Abondio ◽  
Marco Sazzini ◽  
Paolo Garagnani ◽  
Alessio Boattini ◽  
Daniela Monti ◽  
...  
Keyword(s):  
Evolutionary Dynamics ◽  
Human Longevity ◽  
Human Populations ◽  
Worldwide Distribution ◽  
Age Related ◽  
Gene Environment ◽  
Genome Wide ◽  
History Of ◽  
Extreme Longevity ◽  
Adaptive Role

Human longevity is a complex phenotype resulting from the combinations of context-dependent gene-environment interactions that require analysis as a dynamic process in a cohesive ecological and evolutionary framework. Genome-wide association (GWAS) and whole-genome sequencing (WGS) studies on centenarians pointed toward the inclusion of the apolipoprotein E (APOE) polymorphisms ε2 and ε4, as implicated in the attainment of extreme longevity, which refers to their effect in age-related Alzheimer’s disease (AD) and cardiovascular disease (CVD). In this case, the available literature on APOE and its involvement in longevity is described according to an anthropological and population genetics perspective. This aims to highlight the evolutionary history of this gene, how its participation in several biological pathways relates to human longevity, and which evolutionary dynamics may have shaped the distribution of APOE haplotypes across the globe. Its potential adaptive role will be described along with implications for the study of longevity in different human groups. This review also presents an updated overview of the worldwide distribution of APOE alleles based on modern day data from public databases and ancient DNA samples retrieved from literature in the attempt to understand the spatial and temporal frame in which present-day patterns of APOE variation evolved.

BMI-associated gene variants in FTO and cardiometabolic and brain disease: obesity or pleiotropy?

2019 ◽  
Vol 51 (8) ◽  
pp. 311-322 ◽  
Author(s):  
Ingeborg M. M. Ganeff ◽  
Maxime M. Bos ◽  
Diana van Heemst ◽  
Raymond Noordam
Keyword(s):  
Body Weight ◽  
Association Studies ◽  
Brain Disease ◽  
Genome Wide Association Studies ◽  
Gene Variants ◽  
Biological Mechanisms ◽  
Related Disease ◽  
Age Related ◽  
Genome Wide

Obesity is a causal risk factor for the development of age-related disease conditions, which includes Type 2 diabetes mellitus, cardiovascular disease, and dementia. In genome-wide association studies, genetic variation in FTO is strongly associated with obesity and has been described across different ethnic backgrounds and life stages. To date, much work has been devoted on determining the biological mechanisms via which FTO affects body weight regulation and ultimately contributes to age-related cardiometabolic and brain disease. The main hypotheses of the involved biological mechanisms include the involvement of FTO in habitual food intake and energy expenditure. In this narrative review, our overall aim is to provide an overview on how FTO gene variants could increase the risk of developing age-related disease conditions. Specifically, we will discuss the state of the literature based on the different hypotheses how FTO regulates body weight and ultimately contributes to cardiometabolic disease and brain disease.

scholarly journals A genome-wide scan for common variants affecting the rate of age-related cognitive decline

2012 ◽  
Vol 33 (5) ◽  
pp. 1017.e1-1017.e15 ◽  
Author(s):  
Philip L. De Jager ◽  
Joshua M. Shulman ◽  
Lori B. Chibnik ◽  
Brendan T. Keenan ◽  
Towfique Raj ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Common Variants ◽  
Age Related ◽  
Genome Wide ◽  
A Genome ◽  
Age Related Cognitive Decline ◽  
Genome Wide Scan

The UK Adult Twin Registry (TwinsUK)

2006 ◽  
Vol 9 (6) ◽  
pp. 899-906 ◽  
Author(s):  
Tim D. Spector ◽  
Frances M. K. Williams
Keyword(s):  
Aging Process ◽  
Association Studies ◽  
Media Campaigns ◽  
The United Kingdom ◽  
Twin Registry ◽  
Age Related ◽  
Genome Wide ◽  
The Uk ◽  
Intermediate Traits ◽  
Genome Wide Scan

AbstractThe UK Adult Twin Registry was started in 1993 and consists of approximately 10,000 monozygotic (MZ) and dizygotic (DZ) adult Caucasian twins aged 16 to 85 years from all over the United Kingdom, plus some parents and siblings. It now incorporates previous twin registries from the Institute of Psychiatry and Aberdeen University. This is a volunteer sample recruited by successive media campaigns without selecting for particular diseases or traits. All twins receive a series of detailed disease and environmental questionnaires. The majority of twins have been assessed in detail clinically at several time points for several hundred phenotypes related to common diseases or intermediate traits. The focus to date has been primarily in 5 areas — cardiovascular, metabolic, musculoskeletal, ophthalmologic diseases as well as the aging process. Over 3000 DZ twins have had a 10cM genome-wide scan performed and 5000 twins tagged for over 200 candidate genes allowing both linkage and association studies. The resource has led to many successful and innovative research projects particularly in common age-related diseases, and has led to collaborations with over 80 groups worldwide.

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