Faculty Opinions recommendation of Early childhood behavioral inhibition predicts cortical thickness in adulthood.

2017 ◽  
Author(s):  
Michiel Westenberg ◽  
Janna Marie Bas-Hoogendam
Keyword(s):  
Early Childhood ◽  
Cortical Thickness ◽  
Behavioral Inhibition

scholarly journals Early Childhood Behavioral Inhibition Predicts Cortical Thickness in Adulthood

2016 ◽  
Vol 55 (2) ◽  
pp. 122-129.e1 ◽  
Author(s):  
Chad M. Sylvester ◽  
Deanna M. Barch ◽  
Michael P. Harms ◽  
Andy C. Belden ◽  
Timothy J. Oakberg ◽  
...  
Keyword(s):  
Early Childhood ◽  
Cortical Thickness ◽  
Behavioral Inhibition

scholarly journals 0334 Hippocampal Development, Slow Wave Activity, and Nap-Dependent Memory Consolidation in Early Childhood

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A127-A127
Author(s):  
S Lokhandwala ◽  
T Allard ◽  
T Riggins ◽  
R M Spencer
Keyword(s):  
Early Childhood ◽  
Brain Development ◽  
Cortical Thickness ◽  
Memory Consolidation ◽  
Sleep Stage ◽  
Structural Characteristics ◽  
Spatial Task ◽  
Preschool Age ◽  
Brain Maturation ◽  
Declarative Learning

Abstract Introduction Naps support memory consolidation in early childhood. In adults, nap-dependent declarative consolidation is associated with SWA. SWA increases from early childhood into adulthood, and the shift of SWA from occipital to frontal distribution (F/O-ratio) is a marker of brain maturation. Thus, we explored how electrophysiological and structural characteristics of brain development relate to nap-dependent declarative learning in early childhood. Methods Twelve preschool-age children (8 female, M=48 months, SD=0.44) have completed three sessions (~1wk apart) within a larger study. In the first two sessions, children completed a visuo-spatial task before and after a 2-hr nap or wake interval. During the third visit, children underwent MRI assessment. Using PSG, SWA was measured in the delta band over frontal and occipital regions for nREM2 and nREM3 sleep. Results While F/O-ratio of SWA does not currently predict the F/O-ratio of cortical thickness (r(12)=.383, p=.219), right parahippocampal thickness positively correlates with F/O-ratio of SWA in nREM2 (r(12)=.591, p=.043). Nonetheless, children’s performance change following the nap was not associated with either parahippocampal thickness or F/O-ratio of SWA in any sleep stage (all ps>.538). However, performance in children who showed a post-nap benefit (n=5) positively correlated with right parahippocampal thickness (r(5)=.915, p=.029). This was not the case for children who did not show a post-nap benefit (r(7)=-.199, p=.668). Conclusion Although the F/O-ratio of SWA did not predict a similar ratio of cortical thickness, the association between right parahippocampal thickness and F/O-ratio of SWA is evidence that development of SWA parallels cortical development. While there is no overall association between post-nap performance and brain development characteristics, the relation between performance and right parahippocampal thickness in children showing a nap benefit suggests that memory during this age may depend on structural (rather than electrophysiological) brain development changes. Support NIH R21 HD094758 & NSF BCS 1749280

scholarly journals The BDNF gene val66met polymorphism and behavioral inhibition in early childhood

2018 ◽  
Vol 27 (3) ◽  
pp. 543-554
Author(s):  
Matthew R. J. Vandermeer ◽  
Haroon I. Sheikh ◽  
Shiva S. Singh ◽  
Daniel N. Klein ◽  
Thomas M. Olino ◽  
...  
Keyword(s):  
Early Childhood ◽  
Behavioral Inhibition ◽  
Bdnf Gene ◽  
Val66met Polymorphism

scholarly journals Impact of Behavioral Inhibition and Parenting Style on Internalizing and Externalizing Problems from Early Childhood through Adolescence

2009 ◽  
Vol 37 (8) ◽  
pp. 1063-1075 ◽  
Author(s):  
Lela Rankin Williams ◽  
Kathryn A. Degnan ◽  
Koraly E. Perez-Edgar ◽  
Heather A. Henderson ◽  
Kenneth H. Rubin ◽  
...  
Keyword(s):  
Early Childhood ◽  
Parenting Style ◽  
Behavioral Inhibition ◽  
Externalizing Problems ◽  
Internalizing And Externalizing Problems ◽  
Internalizing And Externalizing

scholarly journals Levels of early-childhood behavioral inhibition predict distinct neurodevelopmental pathways to pediatric anxiety

2019 ◽  
Vol 50 (1) ◽  
pp. 96-106 ◽  
Author(s):  
Rany Abend ◽  
Caroline Swetlitz ◽  
Lauren K. White ◽  
Tomer Shechner ◽  
Yair Bar-Haim ◽  
...  
Keyword(s):  
Early Childhood ◽  
Behavioral Inhibition ◽  
Attention Bias ◽  
Anxiety Symptoms ◽  
Childhood And Adolescence ◽  
Cross Sectional ◽  
Linear Mixed Effects ◽  
Pediatric Anxiety ◽  
History Of ◽  
Bias Attention

AbstractBackgroundAnxiety symptoms gradually emerge during childhood and adolescence. Individual differences in behavioral inhibition (BI), an early-childhood temperament, may shape developmental paths through which these symptoms arise. Cross-sectional research suggests that level of early-childhood BI moderates associations between later anxiety symptoms and threat-related amygdala–prefrontal cortex (PFC) circuitry function. However, no study has characterized these associations longitudinally. Here, we tested whether level of early-childhood BI predicts distinct evolving associations between amygdala–PFC function and anxiety symptoms across development.MethodsEighty-seven children previously assessed for BI level in early childhood provided data at ages 10 and/or 13 years, consisting of assessments of anxiety and an fMRI-based dot-probe task (including threat, happy, and neutral stimuli). Using linear-mixed-effects models, we investigated longitudinal changes in associations between anxiety symptoms and threat-related amygdala–PFC connectivity, as a function of early-childhood BI.ResultsIn children with a history of high early-childhood BI, anxiety symptoms became, with age, morenegativelyassociated with right amygdala–left dorsolateral-PFC connectivity when attention was to be maintained on threat. In contrast, with age, low-BI children showed an increasinglypositiveanxiety–connectivity association during the same task condition. Behaviorally, at age 10, anxiety symptoms did not relate to fluctuations in attention bias (attention bias variability, ABV) in either group; by age 13, low-BI children showed a negative anxiety–ABV association, whereas high-BI children showed a positive anxiety–ABV association.ConclusionsEarly-childhood BI levels predict distinct neurodevelopmental pathways to pediatric anxiety symptoms. These pathways involve distinct relations among brain function, behavior, and anxiety symptoms, which may inform diagnosis and treatment.

scholarly journals The serotonin transporter promoter polymorphism moderates the continuity of behavioral inhibition in early childhood

2016 ◽  
Vol 28 (4pt1) ◽  
pp. 1103-1116 ◽  
Author(s):  
Victoria C. Johnson ◽  
Katie R. Kryski ◽  
Haroon I. Sheikh ◽  
Heather J. Smith ◽  
Shiva M. Singh ◽  
...  
Keyword(s):  
Early Childhood ◽  
Anxiety Disorder ◽  
Serotonin Transporter ◽  
Behavioral Inhibition ◽  
Promoter Polymorphism ◽  
Contextual Influences ◽  
Polymorphic Region ◽  
Serotonin Transporter Promoter Polymorphism ◽  
Child Factors ◽  
Parent Characteristics

AbstractPersistently elevated behavioral inhibition (BI) in children is a marker of vulnerability to psychopathology. However, little research has considered the joint influences of caregiver and child factors that may moderate the continuity of BI in early childhood, particularly genetic variants that may serve as markers of biological plasticity, such as the serotonin transporter linked polymorphic region (5-HTTLPR). We explored this issue in 371 preschoolers and their caregivers, examining whether parent characteristics (i.e., overinvolvement or anxiety disorder) and child 5-HTTLPR influenced the continuity of BI between ages 3 and 5. Measures were observational ratings of child BI, observational and questionnaire measures of parenting, and parent interviews for anxiety disorder history, and children were genotyped for the 5-HTTLPR. Parent factors did not moderate the association between age 3 and age 5 BI; however, child BI at age 3 interacted with children's 5-HTTLPR variants to predict age 5 BI, such that children with at least one copy of the short allele exhibited less continuity of BI over time relative to children without this putative plasticity variant. Findings are consistent with previous work indicating the 5-HTTLPR short variant increases plasticity to contextual influences, thereby serving to decrease the continuity of BI in early childhood.

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