scholarly journals Levels of early-childhood behavioral inhibition predict distinct neurodevelopmental pathways to pediatric anxiety

2019 ◽  
Vol 50 (1) ◽  
pp. 96-106 ◽  
Author(s):  
Rany Abend ◽  
Caroline Swetlitz ◽  
Lauren K. White ◽  
Tomer Shechner ◽  
Yair Bar-Haim ◽  
...  
Keyword(s):  
Early Childhood ◽  
Behavioral Inhibition ◽  
Attention Bias ◽  
Anxiety Symptoms ◽  
Childhood And Adolescence ◽  
Cross Sectional ◽  
Linear Mixed Effects ◽  
Pediatric Anxiety ◽  
History Of ◽  
Bias Attention

AbstractBackgroundAnxiety symptoms gradually emerge during childhood and adolescence. Individual differences in behavioral inhibition (BI), an early-childhood temperament, may shape developmental paths through which these symptoms arise. Cross-sectional research suggests that level of early-childhood BI moderates associations between later anxiety symptoms and threat-related amygdala–prefrontal cortex (PFC) circuitry function. However, no study has characterized these associations longitudinally. Here, we tested whether level of early-childhood BI predicts distinct evolving associations between amygdala–PFC function and anxiety symptoms across development.MethodsEighty-seven children previously assessed for BI level in early childhood provided data at ages 10 and/or 13 years, consisting of assessments of anxiety and an fMRI-based dot-probe task (including threat, happy, and neutral stimuli). Using linear-mixed-effects models, we investigated longitudinal changes in associations between anxiety symptoms and threat-related amygdala–PFC connectivity, as a function of early-childhood BI.ResultsIn children with a history of high early-childhood BI, anxiety symptoms became, with age, morenegativelyassociated with right amygdala–left dorsolateral-PFC connectivity when attention was to be maintained on threat. In contrast, with age, low-BI children showed an increasinglypositiveanxiety–connectivity association during the same task condition. Behaviorally, at age 10, anxiety symptoms did not relate to fluctuations in attention bias (attention bias variability, ABV) in either group; by age 13, low-BI children showed a negative anxiety–ABV association, whereas high-BI children showed a positive anxiety–ABV association.ConclusionsEarly-childhood BI levels predict distinct neurodevelopmental pathways to pediatric anxiety symptoms. These pathways involve distinct relations among brain function, behavior, and anxiety symptoms, which may inform diagnosis and treatment.

scholarly journals Association between self-care agency and depression and anxiety in patients with diabetic retinopathy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bo Zhang ◽  
Qin Wang ◽  
Xuancan Zhang ◽  
Li Jiang ◽  
Lezhi Li ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Rural Areas ◽  
Self Care ◽  
Depression Scale ◽  
Anxiety Symptoms ◽  
Depression And Anxiety ◽  
Clinical Factors ◽  
Cross Sectional ◽  
History Of ◽  
Care Agency

Abstract Background This study aimed at investigating: 1) the relationship between self-care agency and depression and anxiety; 2) the sociodemographic and clinical factors associated with depression and anxiety in patients with diabetic retinopathy (DR) in China. Methods A cross-sectional study was conducted. One-hundred and five patients with DR were recruited. Self-care agency was assessed by the exercise of self-care agency (ESCA) scale. Depression and anxiety were assessed by the hospital anxiety and depression scale (HADS-D and HADS-A). Pearson or Spearman correlations were performed to assess the association between self-care agency and depression and anxiety. Stepwise multivariate linear regression analyses were conducted to assess the contribution of the sociodemographic and clinical factors to depression and anxiety. Results Thirty-six (34.3%) and 43 (41.1%) patients exhibited depressive and anxiety symptoms, respectively. Only 24 (22.9%) patients showed a high self-care agency. The ESCA total and subscale scores were negatively correlated depressive symptoms (P < 0.05). Self-care skills were negatively correlated with anxiety symptoms (P < 0.05). ESCA total score, rural residence, history of hypertension and visual acuity were associated with depression; self-care skills and diastolic blood pressure were associated with anxiety. Conclusions Self-care agency negatively correlates with depression and anxiety in patients with DR. Special attention should be paid to patients living in rural areas and/or those having a history of hypertension when assessing depression and anxiety in patients with DR. Future studies are needed to clarify the causal relationship between self-care agency and depression and anxiety.

scholarly journals An epidemiological study on prevalence of hypertension and its risk factors among school boys of Burdwan municipal area

2017 ◽  
Vol 4 (11) ◽  
pp. 4213
Author(s):  
Kaushik Nag ◽  
Manas Patra ◽  
Avijit Paul ◽  
Indranil Saha ◽  
Krishnadas Bhattacharyya ◽  
...  
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Random Sampling ◽  
Statistical Tests ◽  
Categorical Variables ◽  
Childhood And Adolescence ◽  
Adolescent Boys ◽  
Cross Sectional ◽  
Chewing Tobacco ◽  
History Of

Background: High blood pressure in childhood and adolescence is an important part of the natural history of hypertension. The objective of the study was to determine the prevalence and risk factors of hypertension among the adolescent boys of class nine (IX) to twelve (XII).Methods: A school based cross sectional study was undertaken among 894 adolescent boys aged 13 to 18 years from May 2013 to October 2014 of Burdwan municipal area. Schools were selected by Simple random sampling and systematic random sampling was used to include sample students from each school. Statistical tests like chi-square test were applied for categorical variables and p<0.05 taken as statistical significance.Results: The prevalence of hypertension was found to be 5.7%. The study revealed highest prevalence of hypertension in the age group of 13-14 and 17-18 years (6.5%), Muslim religion (17%), General caste (8.4%), and upper socio-economic status (9.3%) among which religion and caste showed significant association with hypertension (P<0.05). Students taking non-vegeterian items ≥5 days a week, chewing tobacco users, obese and having family history were more hypertensive which was statistically significant (p<0.05).Conclusions: The association of hypertension with food habit, tobacco chewing, obesity & family history of hypertension was found to be statistically significant.

scholarly journals IL-6 and IL-10 levels in the umbilical cord blood of newborns with a history of crack/cocaine exposure in utero: a comparative study

2016 ◽  
Vol 38 (1) ◽  
pp. 40-49 ◽  
Author(s):  
Victor Mardini ◽  
Luis Augusto Rohde ◽  
Keila Maria Mendes Ceresér ◽  
Carolina de Moura Gubert ◽  
Emily Galvão da Silva ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Crack Cocaine ◽  
In Utero ◽  
Childhood And Adolescence ◽  
Cocaine Exposure ◽  
Cross Sectional ◽  
History Of ◽  
Spearman Test

Introduction Prenatal cocaine exposure (PCE) is associated with neurobehavioral problems during childhood and adolescence. Early activation of the inflammatory response may contribute to such changes. Our aim was to compare inflammatory markers (IL-6 and IL-10) both in umbilical cord blood and in maternal peripheral blood at delivery between newborns with history of crack/cocaine exposure in utero and non-exposed newborns. Methods In this cross-sectional study, 57 newborns with a history of crack/cocaine exposure in utero (EN) and 99 non-exposed newborns (NEN) were compared for IL-6 and IL-10 levels. Sociodemographic and perinatal data, maternal psychopathology, consumption of nicotine and other substances were systematically collected in cases and controls. Results After adjusting for potential confounders, mean IL-6 was significantly higher in EN than in NEN (10,208.54, 95% confidence interval [95%CI] 1,328.54-19,088.55 vs. 2,323.03, 95%CI 1,484.64-3,161.21; p = 0.007; generalized linear model [GLM]). Mean IL-10 was also significantly higher in EN than in NEN (432.22, 95%CI 51.44-812.88 vs. 75.52, 95%CI 5.64-145.39, p = 0.014; GLM). Adjusted postpartum measures of IL-6 were significantly higher in mothers with a history of crack/cocaine use (25,160.05, 95%CI 10,958.15-39,361.99 vs. 8,902.14, 95%CI 5,774.97-12,029.32; p = 0.007; GLM), with no significant differences for IL-10. There was no correlation between maternal and neonatal cytokine levels (Spearman test, p ≥ 0.28 for all measures). Conclusions IL-6 and IL-10 might be early biomarkers of PCE in newborns. These findings could help to elucidate neurobiological pathways underlying neurodevelopmental changes and broaden the range of possibilities for early intervention.

scholarly journals Higher risk of mental health deterioration during the Covid-19 lockdown among students rather than non-students. The French Confins study

2020 ◽  
Author(s):  
Julie Arsandaux ◽  
Ilaria Montagni ◽  
Mélissa Macalli ◽  
Nathalie Texier ◽  
Mathilde Pouriel ◽  
...  
Keyword(s):  
Mental Health ◽  
Psychiatric Disorders ◽  
Perceived Stress ◽  
Psychological Impact ◽  
Total Sample ◽  
Anxiety Symptoms ◽  
Suicidal Thoughts ◽  
Cross Sectional ◽  
History Of ◽  
Set Up

ABSTRACTBackgroundCovid-19 pandemic and its consequences have raised fears of its psychological impact. The objective of this study was to estimate the effect of student status on mental health conditions during Covid-19 general lockdown among adults in France.MethodsUsing cross-sectional data of the Confins cohort, we estimated the effect of student status on depressive and anxiety symptoms, suicidal thoughts and perceived stress using multivariate logistic regression analyses. Stratified models for college students and non- students were performed to identify associated population-specific factors.ResultsAmong the 2260 included participants, students represented 59% (n=1335 vs 925 non- students) and 78% of the total sample were female. Student status was more frequently associated with depressive symptoms (adjusted OR(aOR)=1.58; 95%CI 1.17;2.14), anxiety symptoms (aOR=1.51; 95%CI 1.10;2.07), perceived stress (n=1919, aOR=1.70, 95%CI 1.26;2.29) and frequent suicidal thoughts (n=1919, aOR=1.57, 95%CI 0.97;2.53). Lockdown conditions that could be potentially aggravating on mental health like isolation had a higher impact on students than non-students.LimitationsParticipants were volunteers, which could limit generalisation of the findings. The cross-sectional design did not allow determining if lockdown impacted directly mental health or if there is another cause. However, we adjusted analyses with the history of psychiatric disorders, and factors related to lockdown conditions were associated with mental health disturbances.ConclusionsCollege student’s mental health is of great importance in the context of the general lockdown set up during the pandemic. Follow-up and interventions should be implemented especially for those at high-risk (younger people and those with history of psychiatric disorders).

scholarly journals Infant Attachment Security and Early Childhood Behavioral Inhibition Interact to Predict Adolescent Social Anxiety Symptoms

2014 ◽  
Vol 86 (2) ◽  
pp. 598-613 ◽  
Author(s):  
Erin Lewis-Morrarty ◽  
Kathryn A. Degnan ◽  
Andrea Chronis-Tuscano ◽  
Daniel S. Pine ◽  
Heather A. Henderson ◽  
...  
Keyword(s):  
Early Childhood ◽  
Social Anxiety ◽  
Behavioral Inhibition ◽  
Attachment Security ◽  
Anxiety Symptoms ◽  
Infant Attachment

scholarly journals Relating outdoor play to sedentary behavior and physical activity in youth - results from a cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Carina Nigg ◽  
Claudia Niessner ◽  
Claudio R. Nigg ◽  
Doris Oriwol ◽  
Steffen C. E. Schmidt ◽  
...  
Keyword(s):  
Physical Activity ◽  
Early Childhood ◽  
Children And Adolescents ◽  
Sedentary Behavior ◽  
Screen Time ◽  
Vigorous Physical Activity ◽  
Outdoor Play ◽  
Childhood And Adolescence ◽  
Research Gaps ◽  
Cross Sectional

Abstract Background Outdoor play, sedentary behavior (SB), and moderate-to-vigorous physical activity (MVPA) are related to youth’s health, however, there are research gaps regarding 1) associations between outdoor play, SB, and MVPA across a broad pediatric age range (6–17 years), and 2) longitudinal associations between outdoor play, SB, and MVPA across childhood and adolescence. Two studies were conducted to address those research gaps: Study 1 aimed to investigate relationships between outdoor play and accelerometer-assessed SB and MVPA in a cross-sectional nationwide sample of children and adolescents in Germany. Study 2 aimed to investigate prospective associations between outdoor play and self-reported screen-time SB and MVPA and in a sample of children with three measurement timepoints across 11 years. Methods Data were obtained of the German national representative Motorik-Modul (MoMo) Study and the German Health Interview and Examination Survey for Children and Adolescents (KiGGS). In Study 1, N = 2278 participants (6–17 years) were included with self-reported outdoor play and accelerometer-assessed SB and MVPA. Associations were examined via multiple linear regressions. In Study 2, N = 570 participants (baseline: 4–7 years) were included in the longitudinal analysis with follow-ups six and 11 years later. Screen-time SB (TV watching and PC/Gaming), MVPA, and outdoor play were self-reported. Associations were investigated through a path prediction model. Results Study 1 showed that compared to <1 h outdoor play, higher engagement in daily outdoor play was related to lower SB (1-2 h: − 9.75 min/day, P = 0.017; ≥2 h: − 17.78 min/day, P < 0.001) and higher MVPA (≥2 h: + 3.87 min/day, P = 0.001). The cross-sectional relationship between MVPA and outdoor play was moderated by sex (in favor of males) and age (in favor of younger children). Study 2 showed that outdoor play in early childhood negatively predicted PC use/Gaming in later childhood, but was unrelated to MVPA. Conclusion In Study 1, outdoor play was negatively related to SB cross-sectionally. In Study 2, outdoor play in early childhood was negatively related to PC and Gaming time in later childhood. Thus, providing outdoor play opportunities, especially during early childhood, has potential to prevent SB. Future research should investigate longitudinal relationships using device-based assessments for SB and MVPA.

scholarly journals Awareness and Attitude regarding Cardiovascular Diseases among the Adolescents Studying in Grade 12 in Makawanpur Multiple Campus in Nepal

2021 ◽  
Vol 11 (5) ◽  
pp. 261-268
Author(s):  
Manju Nepal ◽  
Bandana Pokharel ◽  
Parbati Nepal
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Favorable Attitude ◽  
P Value ◽  
Childhood And Adolescence ◽  
Chi Square ◽  
Cross Sectional ◽  
History Of ◽  
Level Of Significance ◽  
Selection Of

Objective: Cardiovascular diseases (CVD) are the leading cause of death worldwide. It is crucial to detect risk factors and behaviors throughout childhood and adolescence to advocate as a strategy to reduce risk of CVD in adulthood. The objective of this study was to assess the awareness and attitude regarding Cardiovascular Diseases among the Adolescents Studying in Grade 12 in Makawanpur Multiple Campus in Nepal. Materials and Methods: This descriptive cross sectional analytical study was conducted among 135 adolescents studying in grade 12 in Makwanpur Multiple Campus, Hetauda, Nepal. The selection of study site was done purposively. A structured self-developed questionnaire was used to assess the awareness on cardiovascular disease and five-point Likert scale to assess attitude regarding cardiovascular diseases were used. Statistical package for social sciences (SPSS) version 20 was used for data analysis. Both descriptive (frequency, percentage, and mean) and inferential statistics (chi-square) were used to analyze the data. Results: Among 135 respondents, 17(12.6%) respondents had inadequate awareness, 52(38.5%) had moderate awareness and 66(48.9%) had adequate awareness. The mean awareness on cardiovascular disease was 11.90±2.83. Similarly more than half of respondents 69(51.1%) had favorable attitude toward cardiovascular disease. A statistically significant association between gender of the respondents and awareness level was found as Chi-square p value less than 0.05 (p=.011) at 5% level of significance. Similarly, statistically significant association between family history of CVD and attitude on cardiovascular disease was found at 5% level of significance (p value=.027). Conclusion: Nearly half of respondents had adequate level of awareness regarding cardiovascular diseases whereas more than half of respondents had favorable attitude toward cardiovascular disease. Key words: Adolescent, Attitude, Awareness, Cardiovascular Diseases.

F28. Levels of Early-Life Behavioral Inhibition Temperament Predict Distinct Neurodevelopmental Pathways to Pediatric Anxiety Symptoms

2018 ◽  
Vol 83 (9) ◽  
pp. S248
Author(s):  
Rany Abend ◽  
Caroline Swetlitz ◽  
Lauren K. White ◽  
Tomer Shechner ◽  
Yair Bar-Haim ◽  
...  
Keyword(s):  
Behavioral Inhibition ◽  
Early Life ◽  
Anxiety Symptoms ◽  
Pediatric Anxiety

scholarly journals Relationship between CD14 and IgA Levels with the Early Childhood Caries Event Children Age 3–5 Years

2020 ◽  
Vol 8 (D) ◽  
pp. 213-217
Author(s):  
Deli Mona ◽  
Gusti Revilla ◽  
Yanwirasti Yanwirasti ◽  
Nila Kusuma
Keyword(s):  
Early Childhood ◽  
Early Childhood Caries ◽  
Dental Health ◽  
Total Sample ◽  
Elisa Method ◽  
Cross Sectional ◽  
History Of ◽  
The Mean ◽  
Early Caries ◽  
Childhood Caries

BACKGROUND: Early childhood caries (ECC) is a problem in the field of dental health that occurs in infants and toddlers around the world. AIM: This study aims to relationship between CD14 and IgA levels with the ECC event children age 3–5 years. MATERIALS AND METHODS: This type of research is an observational cross-sectional comparative design between children with caries and non-caries. Samples are children aged 3–5 years with a history of consuming bottle milk. The number of samples was 28 people for each group (caries and non-caries) so that the total sample was 56 people. The CD14 and IgA levels measured using the ELISA method. The statistical test used is an independent t-test. p < 0.05 was said to be statistically significant. RESULTS: The results showed that the mean of CD14 levels was higher in the group caries than in the non-caries, while IgA levels were higher in the group non-caries than in the caries group. CONCLUSION: This study concluded that early caries childhood caries event children age 3–5 years increased the levels of IgA and decreased CD14 levels.

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