Faculty Opinions recommendation of Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction.

2017 ◽  
Author(s):  
David Wasserman
Keyword(s):  
Caloric Restriction ◽  
Glucose Intolerance ◽  
Young Male ◽  
Male Rats ◽  
Adiposity Rebound ◽  
Daily Exercise

scholarly journals Caloric restriction suppresses exercise-induced hippocampal BDNF expression in young male rats

2018 ◽  
Vol 7 (4) ◽  
pp. 239-245
Author(s):  
Shohei Dobashi ◽  
Chinatsu Aiba ◽  
Daisuke Ando ◽  
Masataka Kiuchi ◽  
Mitsuya Yamakita ◽  
...  
Keyword(s):  
Caloric Restriction ◽  
Young Male ◽  
Male Rats ◽  
Bdnf Expression ◽  
Exercise Induced

scholarly journals Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction

2016 ◽  
Vol 311 (1) ◽  
pp. E56-E68 ◽  
Author(s):  
Trevor Teich ◽  
Emily C. Dunford ◽  
Deanna P. Porras ◽  
Jacklyn A. Pivovarov ◽  
Jacqueline L. Beaudry ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Receptor Antagonist ◽  
Caloric Restriction ◽  
Mass Gain ◽  
Male Rats ◽  
Tissue Mass ◽  
Adiposity Rebound ◽  
Adipose Tissue Mass

Severe caloric restriction (CR), in a setting of regular physical exercise, may be a stress that sets the stage for adiposity rebound and insulin resistance when the food restriction and exercise stop. In this study, we examined the effect of mifepristone, a glucocorticoid (GC) receptor antagonist, on limiting adipose tissue mass gain and preserving whole body insulin sensitivity following the cessation of daily running and CR. We calorically restricted male Sprague-Dawley rats and provided access to voluntary running wheels for 3 wk followed by locking of the wheels and reintroduction to ad libitum feeding with or without mifepristone (80 mg·kg−1·day−1) for 1 wk. Cessation of daily running and CR increased HOMA-IR and visceral adipose mass as well as glucose and insulin area under the curve during an oral glucose tolerance test vs. pre-wheel lock exercised rats and sedentary rats (all P < 0.05). Insulin sensitivity and glucose tolerance were preserved and adipose tissue mass gain was attenuated by daily mifepristone treatment during the post-wheel lock period. These findings suggest that following regular exercise and CR there are GC-induced mechanisms that promote adipose tissue mass gain and impaired metabolic control in healthy organisms and that this phenomenon can be inhibited by the GC receptor antagonist mifepristone.

Caloric restriction following early-life high fat-diet feeding represses skeletal muscle TNF in male rats

2021 ◽  
Vol 91 ◽  
pp. 108598
Author(s):  
Diego Hernández-Saavedra ◽  
Laura Moody ◽  
Xinyu Tang ◽  
Zachary J. Goldberg ◽  
Alex P. Wang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Caloric Restriction ◽  
High Fat Diet ◽  
Early Life ◽  
Male Rats ◽  
High Fat

Direct and indirect effects of kisspeptin on liver oxidant and antioxidant systems in young male rats

2010 ◽  
Vol 28 (4) ◽  
pp. 293-299 ◽  
Author(s):  
M. Aydin ◽  
S. Oktar ◽  
Z. Yonden ◽  
O. H. Ozturk ◽  
B. Yilmaz
Keyword(s):  
Indirect Effects ◽  
Young Male ◽  
Male Rats ◽  
Antioxidant Systems ◽  
Direct And Indirect Effects
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