Faculty Opinions recommendation of Diabetes mellitus is associated with higher risk of developing decompensated cirrhosis in chronic hepatitis C patients.

2016 ◽  
Author(s):  
Guadalupe Garcia-Tsao ◽  
Uyen Kim To
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Decompensated Cirrhosis ◽  
Chronic Hepatitis C Patients

scholarly journals The Prevalence and Determinants of Hepatic Steatosis Assessed by Controlled Attenuation Parameter in Thai Chronic Hepatitis C Patients

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
A. Sirinawasatien ◽  
T. Techasirioangkun
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Hepatic Steatosis ◽  
Chronic Hepatitis C ◽  
Liver Stiffness ◽  
Controlled Attenuation Parameter ◽  
Attenuation Parameter ◽  
The Mean ◽  
Chronic Hepatitis C Patients

Aims. To describe the prevalence of hepatic steatosis using a controlled attenuation parameter (CAP) and to identify the determinants associated with steatosis in Thai chronic hepatitis C patients. Patients and Methods. An observational study was conducted among consecutive chronic hepatitis C patients who underwent vibration-controlled transient elastography (VCTE, FibroScan®) with CAP and followed up at Rajavithi Hospital, Bangkok, Thailand, between June 2018 and May 2019. Hepatic steatosis (i.e., steatosis grades S1-3) was defined by the CAP cutoff value of ≥248 (dB/m). VCTE with CAP assessments and medical records were retrospectively reviewed, and the prevalence and determinants of hepatic steatosis were analyzed. Results. A total of 197 eligible patients, of whom 127 (64.5%) were male, were included. The mean age was 54.52 years (SD 9.49 years), and 41.1% of subjects had a body mass   index ≥ 25 . The prevalence of hepatic steatosis was 26.9%. The mean liver stiffness measurement (LSM) was 21.50 kPa (SD 15.58 kPa), and 61.9% of the study population had cirrhosis, which was defined as LSM ≥ 12.5  kPa. Genotype (GT) 3 was predominant at 40.1%, followed by GT1 at 38.1% and GT6 at 21.8%. The median serum hepatitis C virus viral load was 1,100,000 IU/mL (range 5,824-20,436,840). The significant determinants of hepatic steatosis were obesity (aOR 8.58 (95% CI: 3.41-21.54)) and diabetes mellitus (aOR 3.30 (95% CI: 1.24-8.78)). Conclusion. A large proportion of these Thai chronic hepatitis C patients (26.9%) had hepatic steatosis, which was strongly associated with host metabolic factors, e.g., obesity ( BMI ≥ 25 ) and diabetes mellitus. These cofactors contributed to the progression of liver disease to cirrhosis and required concurrent management with antiviral therapy.

S1285 Type 2 Diabetes Mellitus is Associated With Hepatic Fibrosis in Chronic Hepatitis C Patients in Taiwan

2010 ◽  
Vol 138 (5) ◽  
pp. S-220-S-221
Author(s):  
Chia-Yen Dai ◽  
Jee-Fu Huang ◽  
Ming-Yen Hsieh ◽  
Nai-Jen Hou ◽  
Zu-Yau Lin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Hepatic Fibrosis ◽  
Chronic Hepatitis C Patients
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