Faculty Opinions recommendation of Removal of all ovarian tissue versus conserving ovarian tissue at time of hysterectomy in premenopausal patients with benign disease: study using routine data and data linkage.

Author(s):  
Rosemarie Heyn
Author(s):  
Amy Mizen ◽  
Sarah Rodgers ◽  
Richard Fry ◽  
Ronan Lyons

ABSTRACTObjectivesLinking routinely collected health and environment data can allow for large scale evaluations of how our environment impacts our health. Our data linkage approach advances previous research where residence-based environmental exposures were anonymously linked in the SAIL databank using Residential Anonymous Linking Fields (RALFs). The dose-response relationship between exposure to food and dietary intake has not been widely investigated. Previous research found conflicting views on whether increased environmental exposure to unhealthy food contributes to higher BMIs. This may have been due to different methodological approaches, including imprecise exposures, small numbers, and the use of self-reported BMIs. ApproachThis investigation calculated food exposure environments for routes from all homes to and from school. A Geographic Information System was used to calculate the environmental exposures along all potential routes up to a maximum age-appropriate walking distance from each school. Once within the SAIL databank we selected relevant routes using linked demographic and pupil datasets. To maintain privacy, the primary (doctoral) researcher generating the environmental exposures, did not have access to the final household-level exposure data in their identifiable form. The researcher automated their method so a second researcher could run the GIS analysis. Accuracy of modelled exposures will be compared with actual routes collected from GPS traces of children walking to school. ResultsRemoving access to the final identifiable household-level route exposures enabled the primary researcher to complete analysis on the combined household and individual-level data within the secure environment. The environmental exposures were linked with routine health data from the SAIL databank; including BMI as an indicator of obesity. BMI data for 4-5 year olds, and a sample of 1300 13-14 year olds were linked to associated environmental exposures. ConclusionDepending on modelled accuracy, a GIS and data linkage approach may allow the investigation of natural experiments and intervention evaluation at the scale of the total population. This is the first step towards anonymously modelling part of the daily exposure environment using routine data. A limitation is the lack of routinely collected BMI data for older children and teenagers an age when they are more likely to have the option to choose to buy food on the school route. This work will have many potential applications, including the delivery and evaluation of multiple school and workplace commuting interventions.


2017 ◽  
Vol 77 (10) ◽  
pp. 1088-1094 ◽  
Author(s):  
Veronika Guenther ◽  
Ibrahim Alkatout ◽  
Wiebe Junkers ◽  
Dirk Bauerschlag ◽  
Nicolai Maass ◽  
...  

AbstractMany premenopausal patients who develop breast cancer have not yet completed their family planning, so measures of fertility protection to preserve their fertile potential would be beneficial. Polychemotherapy causes irreversible damage to the ovarian follicles – irrespective of whether in a neoadjuvant or adjuvant setting – and this can sometimes result in permanent infertility. Depending on which cytostatic agents are used and on the age-related ovarian reserve of the woman, gonadotoxic risk must be classified as low, moderate or high. Options of fertility preservation include: a) cryopreservation of fertilised or unfertilised oocytes. After ovarian hyperstimulation, mature oocytes are retrieved by transvaginal follicle aspiration, after which they are cryopreserved, either unfertilised or on completion of IVF or ICSI treatment. During b) cryopreservation of ovarian tissue, about 50% of the ovarian cortex of one ovary is resected with the aid of a laparoscopic procedure and cryopreserved. The application of c) GnRH agonists as a medicinal therapy option is an attempt at endocrine ovarian suppression in order to protect oocytes, granulosa cells and theca cells from the cytotoxic effect of chemotherapy.


Author(s):  
Clarissa Giebel ◽  
Joe Hollinghurst ◽  
Ashley Akbari ◽  
Christian Schnier ◽  
Tim Wilkinson ◽  
...  

2012 ◽  
Vol 98 (3) ◽  
pp. 720-725 ◽  
Author(s):  
Jacques Donnez ◽  
Pascale Jadoul ◽  
Céline Pirard ◽  
Graham Hutchings ◽  
Dominique Demylle ◽  
...  

Author(s):  
John Wright

ABSTRACTObjectivesBig data and data linkage offer great potential for improving health, but the shallowness of much routine data is a major limiting factor. We explore how connecting wide routine data (big data) and deep research data (little data) can harness the real potential of data linkage. ApproachWe have linked routine clinical data from education and health (primary and secondary care) for a well-characterised birth cohort (Born in Bradford) with phenotype and genotype data on almost 14,000 families. We explore the potential for this combination of big and small data to address key research priorities in health and education research. ResultsWe present examples of the complementarity of routine and research data linkage in four varied domains: 1) Health care: how does postnatal mental health need (small data) match with mental health demand (big data)?2) Education: how do early life exposures (small data) influence school readiness and standardised assessment tests (big data)?3) Genetics: what is the impact of rare mutations (small data) on health service uptake (big data)?4) Public health: how can big data and small data be used to evaluate the effectiveness of early life interventions? Pros and cons of both big data and small data are identified. Some lifestyle and demographic factors are more likely to accurate from bespoke research data collection, but clinical and educational measures may be better gleaned from routine records. The reliability of the different sources of data is discussed. ConclusionsOur results illustrate the symbiosis of combining research and routine datasets. Opportunities for harnessing this power through combining routine data with cohort studies, clinical trials and national surveys are explored.


2016 ◽  
Vol 178 (1-3) ◽  
pp. 107-108 ◽  
Author(s):  
R. Pearsall ◽  
J. Gareze ◽  
J. Park ◽  
A. Walker ◽  
J. Langan-Martin ◽  
...  
Keyword(s):  

Rheumatology ◽  
2015 ◽  
Vol 54 (9) ◽  
pp. 1563-1572 ◽  
Author(s):  
Roxanne Cooksey ◽  
Sinead Brophy ◽  
Michael Dennis ◽  
Helen Davies ◽  
Mark Atkinson ◽  
...  

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