Faculty Opinions recommendation of Regulation of life span by the gut microbiota in the short-lived African turquoise killifish.

2017 ◽  
Author(s):  
Jürg Bahler
Keyword(s):  
Gut Microbiota ◽  
Life Span

scholarly journals Regulation of Life Span by The Gut Microbiota in The Short-Lived African Turquoise Killifish

2017 ◽  
Author(s):  
Patrick Smith ◽  
David Willemsen ◽  
Miriam Popkes ◽  
Franziska Metge ◽  
Edson Gandiwa ◽  
...  
Keyword(s):  
Bacterial Community ◽  
Gut Microbiota ◽  
Life Span ◽  
Middle Age ◽  
External Environment ◽  
Systemic Effects ◽  
Life Span Extension ◽  
Nothobranchius Furzeri ◽  
Vertebrate Model

ABSTRACTGut bacteria occupy the interface between the organism and the external environment, contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during host aging is largely unexplored. Here, using the African turquoise killifish (Nothobranchius furzeri), a naturally short-lived vertebrate, we show that the gut microbiota plays a key role in modulating vertebrate life span. Recolonizing the gut of middle-age individuals with bacteria from young donors resulted in life span extension and delayed behavioral decline. This intervention prevented the decrease in microbial diversity associated with host aging and maintained a young-like gut bacterial community, characterized by overrepresentation of the key genera Exiguobacterium, Planococcus, Propionigenium and Psychrobacter. Our findings demonstrate that the natural microbial gut community of young individuals can causally induce long-lasting beneficial systemic effects that lead to life span extension in a vertebrate model.

scholarly journals Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Patrick Smith ◽  
David Willemsen ◽  
Miriam Popkes ◽  
Franziska Metge ◽  
Edson Gandiwa ◽  
...  
Keyword(s):  
Bacterial Community ◽  
Gut Microbiota ◽  
Life Span ◽  
Middle Age ◽  
External Environment ◽  
Systemic Effects ◽  
Life Span Extension ◽  
Nothobranchius Furzeri ◽  
Vertebrate Model

Gut bacteria occupy the interface between the organism and the external environment, contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during host aging is largely unexplored. Here, using the African turquoise killifish (Nothobranchius furzeri), a naturally short-lived vertebrate, we show that the gut microbiota plays a key role in modulating vertebrate life span. Recolonizing the gut of middle-age individuals with bacteria from young donors resulted in life span extension and delayed behavioral decline. This intervention prevented the decrease in microbial diversity associated with host aging and maintained a young-like gut bacterial community, characterized by overrepresentation of the key genera Exiguobacterium, Planococcus, Propionigenium and Psychrobacter. Our findings demonstrate that the natural microbial gut community of young individuals can causally induce long-lasting beneficial systemic effects that lead to life span extension in a vertebrate model.

Carbohydrate-restricted diet alters the gut microbiota, promotes senescence and shortens the life span in senescence-accelerated prone mice

2020 ◽  
Vol 78 ◽  
pp. 108326 ◽  
Author(s):  
Chaoqi He ◽  
Qiming Wu ◽  
Nao Hayashi ◽  
Fumika Nakano ◽  
Eriko Nakatsukasa ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Life Span ◽  
Restricted Diet

scholarly journals Uncovering Bifidobacteria via Targeted Sequencing of the Mammalian Gut Microbiota

2019 ◽  
Vol 7 (11) ◽  
pp. 535 ◽  
Author(s):  
Gabriele Andrea Lugli ◽  
Sabrina Duranti ◽  
Christian Milani ◽  
Leonardo Mancabelli ◽  
Francesca Turroni ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Gut Microbiota ◽  
Life Span ◽  
Relative Abundance ◽  
Intestinal Mucosa ◽  
Environmental Samples ◽  
Enrichment Method ◽  
Functional Roles ◽  
Genetic Features ◽  
Uptake Of Nutrients

Bifidobacteria are among the most prevalent gut commensals in mammals, playing crucial functional roles that start from their early colonization of the infant gastrointestinal tract and last throughout the life span of their host. Metagenomic approaches have been employed to unveil the genetic features of bifidobacteria in order to understand how they participate in the correct development of a healthy microbiome. Nevertheless, their low relative abundance in many environmental samples may represent a major limitation for metagenomics approaches. To overcome this restriction, we applied an enrichment method that allows amplification of bifidobacterial DNA obtained from human or animal fecal samples for up to 26,500-fold, resulting in the metagenomic reconstruction of genomes belonging to bifidobacterial strains, present at very low abundance in collected samples. Functional predictions of the genes from these reconstructed genomes allows us to identify unique signatures among members of the same bifidobacterial species, highlighting genes correlated with the uptake of nutrients and adhesion to the intestinal mucosa.

scholarly journals Author response: Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

2017 ◽  
Author(s):  
Patrick Smith ◽  
David Willemsen ◽  
Miriam Popkes ◽  
Franziska Metge ◽  
Edson Gandiwa ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Life Span ◽  
Author Response

Continuum of Care Following Sports-Related Concussion

2020 ◽  
Vol 29 (3) ◽  
pp. 1389-1403
Author(s):  
Jessica Brown ◽  
Kelly Knollman-Porter
Keyword(s):  
Young Adults ◽  
Life Span ◽  
Sports Injuries ◽  
Continuum Of Care ◽  
Medical Professional ◽  
Structured Interviews ◽  
Youth Athletes ◽  
Speech Language Pathologist ◽  
History Of ◽  
Injury Reporting

Purpose Although guidelines have changed regarding federally mandated concussion practices since their inception, little is known regarding the implementation of such guidelines and the resultant continuum of care for youth athletes participating in recreational or organized sports who incur concussions. Furthermore, data regarding the role of speech-language pathologists in the historic postconcussion care are lacking. Therefore, the purpose of this retrospective study was to investigate the experiences of young adults with history of sports-related concussion as it related to injury reporting and received follow-up care. Method Participants included 13 young adults with history of at least one sports-related concussion across their life span. We implemented a mixed-methods design to collect both quantitative and qualitative information through structured interviews. Participants reported experiencing 42 concussions across the life span—26 subsequent to sports injuries. Results Twenty-three concussions were reported to a parent or medical professional, 14 resulted in a formal diagnosis, and participants received initial medical care for only 10 of the incidents and treatment or services on only two occasions. Participants reported concussions to an athletic trainer least frequently and to parents most frequently. Participants commented that previous experience with concussion reduced the need for seeking treatment or that they were unaware treatments or supports existed postconcussion. Only one concussion incident resulted in the care from a speech-language pathologist. Conclusion The results of the study reported herein shed light on the fidelity of sports-related concussion care management across time. Subsequently, we suggest guidelines related to continuum of care from injury to individualized therapy.

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