Faculty Opinions recommendation of Use of the serum anti-Müllerian hormone assay as a surrogate for polycystic ovarian morphology: impact on diagnosis and phenotypic classification of polycystic ovary syndrome.

Abstract Context: Polycystic ovarian morphology (PCOM) is present in 25% of normal women in the absence of polycystic ovary syndrome (PCOS); however, the natural history of PCOM is unknown. Objective: We hypothesized that the presence of PCOM predisposes the development of PCOS. Design: The study was a longitudinal follow-up study over 8.2 ± 5.2 yr (mean ± sd; range 1.7–17.5 yr). Setting: The study took place in an outpatient setting. Subjects: Women who took part in a previous study as a normal control and had an ultrasound examination (n = 40) participated. Intervention: Subjects underwent an interval menstrual history, physical exam, blood sampling, and repeat ultrasound in the follicular phase. Main Outcome Measure: Development of PCOS was diagnosed by irregular menses and hyperandrogenism, in the absence of other disorders. Changes in ovarian morphology over time were evaluated. Results: At the baseline visit, 23 women (57.5%) had PCOM and 17 (42.5%) had normal ovarian morphology. One subject with PCOM developed irregular menses and presumptive PCOS. Eleven subjects with PCOM no longer met the criteria for PCOM at follow-up. There was no factor that predicted the change to normal ovarian morphology at the follow-up visit. Conclusions: These data suggest that PCOM in women with regular ovulatory cycles does not commonly predispose the development of PCOS. Although it is unusual to develop PCOM if the ovaries are normal on first assessment, ovaries in women with PCOM no longer meet the criteria for PCOM in approximately half of cases over time.

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Ovarian morphology and endocrine function in polycystic ovary syndrome

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-010-1816-3 ◽

2011 ◽

Vol 284 (6) ◽

pp. 1443-1448 ◽

Cited By ~ 8

Author(s):

Gilberto Tena ◽

Carlos Moran ◽

Rocio Romero ◽

Segundo Moran

Keyword(s):

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Endocrine Function ◽

Ovary Syndrome ◽

Ovarian Morphology

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Relationship of ovarian morphology to degree of menstrual cycle dysfunction and insulin resistance in polycystic ovary syndrome (PCOS)

Fertility and Sterility ◽

10.1016/j.fertnstert.2010.07.271 ◽

2010 ◽

Vol 94 (4) ◽

pp. S69

Author(s):

K.M. Brennan ◽

M. Brower ◽

M. Pall ◽

U. Ezeh ◽

C.A. Torralba ◽

...

Keyword(s):

Insulin Resistance ◽

Menstrual Cycle ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Ovarian Morphology ◽

Relationship Of

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Contemporary approaches to the management of polycystic ovary syndrome

Therapeutic Advances in Endocrinology and Metabolism ◽

10.1177/2042018818756790 ◽

2018 ◽

Vol 9 (4) ◽

pp. 123-134 ◽

Cited By ~ 9

Author(s):

Renato Pasquali

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary Syndrome ◽

Ovarian Function ◽

Polycystic Ovary ◽

Review Article ◽

Metabolic Abnormalities ◽

Androgen Excess ◽

Ovary Syndrome ◽

Ovulatory Dysfunction ◽

Ovarian Morphology

Polycystic ovary syndrome (PCOS) is a common disorder in women in their reproductive years and is characterized by androgen excess, ovulatory dysfunction, and polycystic ovarian morphology. It is also associated with several metabolic abnormalities, particularly insulin resistance and obesity, which play an important role in the pathophysiology of PCOS and, in particular, negatively influence ovarian function and fertility. This review article summarizes the available treatment for women with PCOS. Specifically, current and potentially new therapies are discussed.

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